Publications

Current opinion in genetics & development

The trithorax-group and polycomb-group chromatin modifiers: implications for disease.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Phase I and pharmacokinetic study of irinotecan administered as a low-dose, continuous intravenous infusion over 14 days in patients with malignant solid tumors.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Phase I and pharmacokinetic study of a daily times 5 short intravenous infusion schedule of 9-aminocamptothecin in a colloidal dispersion formulation in patients with advanced solid tumors.

Cancer research

Alkyl-lysophospholipids activate the SAPK/JNK pathway and enhance radiation-induced apoptosis.

15-05-1999

The Journal of biological chemistry

Common regulation of apoptosis signaling induced by CD95 and the DNA-damaging stimuli etoposide and gamma-radiation downstream from caspase-8 activation.

14-05-1999

Cancer chemotherapy and pharmacology

Paclitaxel in the treatment of human immunodeficiency virus 1-associated Kaposi's sarcoma--drug-drug interactions with protease inhibitors and a nonnucleoside reverse transcriptase inhibitor: a case report study.

13-05-1999

Cancer

The development of a prognostic score for patients with parotid carcinoma.

01-05-1999

British journal of pharmacology

Role of blood-brain barrier P-glycoprotein in limiting brain accumulation and sedative side-effects of asimadoline, a peripherally acting analgaesic drug.

01-05-1999

Trends in genetics : TIG

Mouse models for cancer at center stage. AACR special meeting: Cancer Biology and the Mutant Mouse: New Methods, New Models, New Insights, Keystone Colorado, USA, 31 January-5 February 1999.

01-05-1999

Journal of chromatography. B, Biomedical sciences and applications

Quantification of topotecan and its metabolite N-desmethyltopotecan in human plasma, urine and faeces by high-performance liquid chromatographic methods.

30-04-1999

Advanced drug delivery reviews

P-Glycoprotein, a gatekeeper in the blood-brain barrier.

05-04-1999

European journal of immunology

Systemic T cell expansion during localized viral infection.

Immunology today

Turning the immune system on.

Cancer treatment reviews

Clinical pharmacology of anticancer agents in relation to formulations and administration routes.

Cancer research

Identification and characterization of collaborating oncogenes in compound mutant mice.

The Journal of clinical investigation

Ordering of ceramide formation, caspase activation, and mitochondrial changes during CD95- and DNA damage-induced apoptosis.

Seminars in cell & developmental biology

Cellular memory of transcriptional states by Polycomb-group proteins.

The Journal of pharmacology and experimental therapeutics

Comparative pharmacokinetics of vinblastine after a 96-hour continuous infusion in wild-type mice and mice lacking mdr1a P-glycoprotein.

Cancer chemotherapy and pharmacology

A single 24-hour plasma sample does not predict the carboplatin AUC from carboplatin-paclitaxel combinations or from a high-dose carboplatin-thiotepa-cyclophosphamide regimen.

Biochimica et biophysica acta

CSH Meeting on Cancer Genetics 1998.

25-03-1999

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Phase I and pharmacologic study of the combination of paclitaxel, cisplatin, and topotecan administered intravenously every 21 days as first-line therapy in patients with advanced ovarian cancer.

01-03-1999

British journal of cancer

Phase II trial of topically applied miltefosine solution in patients with skin-metastasized breast cancer.

01-03-1999

Matrix biology : journal of the International Society for Matrix Biology

Biology and function of hemidesmosomes.

Cancer

Cognitive deficits after postoperative adjuvant chemotherapy for breast carcinoma.

British journal of cancer

Potentiation of anti-cancer drug activity at low intratumoral pH induced by the mitochondrial inhibitor m-iodobenzylguanidine (MIBG) and its analogue benzylguanidine (BG).

Therapeutic drug monitoring

Sampling technique from central venous catheters proves critical for pharmacokinetic studies.

British journal of cancer

Bioavailability and toxicity after oral administration of m-iodobenzylguanidine (MIBG).

Oncogene

Rapid dephosphorylation of p107 following UV irradiation.

21-01-1999

Current biology : CB

Multivesicular body morphogenesis requires phosphatidyl-inositol 3-kinase activity.

14-01-1999

Nature

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus.

14-01-1999

Oncogene

Functional interaction between a novel protein phosphatase 2A regulatory subunit, PR59, and the retinoblastoma-related p107 protein.

14-01-1999

Anti-cancer drugs

Topoisomerase I/II inhibitor intoplicine administered as a 24 h infusion: phase I and pharmacologic study.

01-01-1999

British journal of cancer

Increased accumulation of doxorubicin and doxorubicinol in cardiac tissue of mice lacking mdr1a P-glycoprotein.

01-01-1999

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Towards prediction and modulation of treatment response.

01-01-1999

Acta oncologica (Stockholm, Sweden)

Radiation-induced apoptosis--the ceramide-SAPK signaling pathway and clinical aspects.

22-12-1998

Investigational new drugs

Pharmaceutical development of a parenteral lyophilized formulation of the investigational antitumor neuropeptide antagonist [Arg6, D-Trp7,9, MePhe8]-Substance P [6-11].

16-12-1998

The EMBO journal

A link between cell cycle and cell death: Bax and Bcl-2 modulate Cdk2 activation during thymocyte apoptosis.

15-12-1998

Seminars in immunology

Tumor necrosis factor receptor family members in the immune system.

01-12-1998

Journal of chromatography. B, Biomedical sciences and applications

High-performance liquid chromatographic bio-analysis of PSC 833 in human and murine plasma.

20-11-1998

Genes & development

Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1.

15-11-1998

Journal of mass spectrometry : JMS

Quantitative determination of Ecteinascidin 743 in human plasma by miniaturized high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.

Cancer research

High frequency of interactions between lung cancer susceptibility genes in the mouse: mapping of Sluc5 to Sluc14.

Radiation research

Increased expression of glomerular von Willebrand factor after irradiation of the mouse kidney.

Journal of clinical epidemiology

Translation, validation, and norming of the Dutch language version of the SF-36 Health Survey in community and chronic disease populations.