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Radiotherapy: Jan-Jakob Sonke

Jan-JakobSonke.jpg

Jan-Jakob SonkeGroup leader, Ph. D.

About Jan Jakob Sonke

Adaptive Radiotherapy

In our group we aim to develop and clinically implement adaptive radiotherapy techniques to individualize treatment.  Traditionally, medical images of a patient scheduled for radiotherapy are acquired only once during the treatment preparation phase, one or more weeks before the start of treatment delivery. These images are subsequently used for target definition and treatment plan optimization but only represent a snapshot of the patient's anatomy. Over the course of radiation therapy patients undergo continuous changes in posture, anatomy and biology due to both physiology and treatment response. Consequently, the actually delivered dose typically deviates from the optimal dose. Therefore we focus on strategies to monitor these changes through an image feedback loop and adapt the treatment to optimize the treatment outcome in the presence of anatomical and functional changes.

In the past, we have co-developed cone-beam CT (CBCT) scanners integrated with the treatment machine to capture the patient's anatomy just prior to irradiation. Currently, we are investigating both hardware and software solutions to improve the CBCT image quality to more accurately capture anatomical changes. To quantify such changes, (deformable) image registration algorithms are optimized facilitating both couch corrections to align the target to the planned position as well as contour propagation and dose accumulation to adapt the treatment plan. Similarly, repeat functional imaging is utilized to monitor and model radiation response of target and organs at risk. This adaptive radiation therapy framework is also prototyped pre-clinically using a dedicated small animal irradiator. Recently, we started to develop adaptive radiotherapy techniques using an MRI integrated treatment machine providing superior soft tissue and real time imaging."

 

Co-workers

Abdoli, Mehrsima

Mehrsima Abdoli

Postdoctoral fellow

Experience

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La Fontaine, Matthew

Matthew la Fontaine

Postdoctoral fellow

Experience

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Gouw, Zeno (2)

Zeno Gouw

Ph.D. Student

Experience

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Janssen, Natasja

Natasja Janssen

Ph.D. Student

Experience

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van de Lindt, Tessa

Tessa van de Lindt

Ph.D. Student

Experience

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Heike Peulen

Ph.D. Student

Experience

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Kleopatra Pirpinia

Ph.D. Student

Experience

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Protik, Angjelina

Angjelina Protik

Ph.D. Student

Experience

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Anneke van der Reijden

Ph.D. Student

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Javier Salguero

Postdoctoral fellow

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Barbara Stam

Postdoctoral fellow

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Uros Stankovic

Ph.D. Student

Experience

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Yenny Szeto

Ph.D. Student

Experience

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Roel Rozendaal

Ph.D. Student

Experience

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Igor Olaciregui-Ruiz

Postdoctoral fellow

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Maddalena Rossi

Technologist

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Natascha Bruin

Technologist

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Jolien Heukelom

Ph.D. Student

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Key publications View All Publications

  • Adaptive radiotherapy with an average anatomy model: Evaluation and quantification of residual deformations in head and neck cancer patients

    Radiother Oncol. 2013 Dec;109(3):463-8. doi: 10.1016/j.radonc.2013.08.007. Epub 2013 Sep 7. PMID: 24021348

    van Kranen S, Mencarelli A, van Beek S, Rasch C, van Herk M, Sonke J-J.

    Link to Pubmed
  • Respiratory correlated cone beam CT

    Med Phys. 2005 Apr;32(4):1176-86. PubMed PMID: 15895601.

    Sonke J-J, Zijp L, Remeijer P, van Herk M.

    Read more
 
 

Recent publications View All Publications

  • Target delineation variability and corresponding margins of peripheral early stage NSCLC treated with stereotactic body radiotherapy

    Radiother Oncol. 2015 Mar 11. pii: S0167-8140(15)00103-6

    Peulen H, Belderbos J, Guckenberger M, Hope A, Grills I, van Herk M, Sonke J-J.

    Link to Pubmed
  • Late follow-up of the randomized radiation and concomitant high-dose intra-arterial or intravenous cisplatin (RADPLAT) trial for advanced head and neck cancer, Head Neck

    2015 Feb 27. doi: 10.1002/hed.24023. [Epub ahead of print]

    Heukelom J, Lopez-Yurda M, Balm AJ, Wijers OB, Buter J, Gregor T, Wiggenraad R, de Boer JP, Tan IB, Verheij M, Sonke J-J, Rasch CR. ...

    Link to Pubmed
 

Contact

  • Office manager

    Diedie van Dinten

  • E-mail

    d.v.dinten@nki.nl

  • Telephone Number

    +31 (0) 20 512 1731

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