Publications

Nature reviews. Genetics

Alternative cleavage and polyadenylation: extent, regulation and function.

European journal of cancer (Oxford, England : 1990)

Adrenocortical carcinoma: a population-based study on incidence and survival in the Netherlands since 1993.

The Journal of pathology

Identification of recurrent FGFR3 fusion genes in lung cancer through kinome-centred RNA sequencing.

Annals of surgical oncology

Early assessment of axillary response with ¹⁸F-FDG PET/CT during neoadjuvant chemotherapy in stage II-III breast cancer: implications for surgical management of the axilla.

Breast cancer research and treatment

Breast cancer subtyping by immunohistochemistry and histological grade outperforms breast cancer intrinsic subtypes in predicting neoadjuvant chemotherapy response.

European journal of endocrinology

Surgery for adrenocortical carcinoma in The Netherlands: analysis of the national cancer registry data.

British journal of clinical pharmacology

Optimizing drug development of anti-cancer drugs in children using modelling and simulation.

PloS one

Kindlin-1 regulates integrin dynamics and adhesion turnover.

19-06-2013

Nucleic Acids Res.

Integrated analysis of microRNA and mRNA expression: adding biological significance to microRNA target predictions

14-06-2013

Scientific reports

Defined lipid analogues induce transient channels to facilitate drug-membrane traversal and circumvent cancer therapy resistance.

07-06-2013

Nature

A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence.

06-06-2013

Cancer Research

Loss of p120-catenin induces metastatic progression of breast cancer by inducing anoikis resistance and augmenting growth factor receptor signaling

03-06-2013

Nat Commun.: Nature communications

ARF triggers senescence in Brca2-deficient cells by altering the spectrum of p53 transcriptional targets

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Prognostic parameters for acute esophagus toxicity in intensity modulated radiotherapy and concurrent chemotherapy for locally advanced non-small cell lung cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Vemurafenib as neoadjuvant treatment for unresectable regional metastatic melanoma.

Breast cancer research and treatment

CYP2C19 2 predicts substantial tamoxifen benefit in postmenopausal breast cancer patients randomized between adjuvant tamoxifen and no systemic treatment.

Psycho-oncology

Assessing the impact of cancer among Dutch non-Hodgkin lymphoma survivors compared with their American counterparts: a cross-national study.

Familial cancer

100 years Lynch syndrome: what have we learned about psychosocial issues?

Cancer

Population-based cancer registries for quality-of-life research: a work-in-progress resource for survivorship studies?

Antimicrobial agents and chemotherapy

Severe skin toxicity in pediatric oncology patients treated with voriconazole and concomitant methotrexate.

Cancer treatment reviews

Is combination therapy the next step to overcome resistance and reduce toxicities in melanoma?

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Local dose-effect relations for lung perfusion post stereotactic body radiotherapy.

Oral oncology

Can extranodal spread in head and neck cancer be detected on MR imaging.

Cancer

The role of comprehensive cancer centers in survivorship care.

Clinical pharmacokinetics

Oral anticancer drugs: mechanisms of low bioavailability and strategies for improvement.

Breast cancer research and treatment

Platform comparisons for identification of breast cancers with a BRCA-like copy number profile.

Drug delivery and translational research

Pharmacokinetic evaluation of three oral formulations of docetaxel boosted with ritonavir: two single-drug formulations vs. a fixed-dose combination tablet.

Nature communications

Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin.

30-05-2013

The EMBO journal

The chromodomain helicase Chd4 is required for Polycomb-mediated inhibition of astroglial differentiation.

29-05-2013

Genome biology

DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus.

28-05-2013

British journal of cancer

Triple-negative breast cancer: BRCAness and concordance of clinical features with BRCA1-mutation carriers.

28-05-2013

Nature communications

Assembly of a π-π stack of ligands in the binding site of an acetylcholine-binding protein.

23-05-2013

PloS one

Analysis of tumor heterogeneity and cancer gene networks using deep sequencing of MMTV-induced mouse mammary tumors.

22-05-2013

PloS one

Intravital FRET imaging of tumor cell viability and mitosis during chemotherapy.

22-05-2013

The breast journal

Paclitaxel, carboplatin, and trastuzumab in a neo-adjuvant regimen for HER2-positive breast cancer.

21-05-2013

The oncologist

Concise drug review: azacitidine and decitabine.

15-05-2013

The breast journal

Major changes in chemotherapy regimens administered to breast cancer patients during 2000-2008 in the Netherlands.

15-05-2013

International journal of cancer

P-glycoprotein and cytochrome P450 3A act together in restricting the oral bioavailability of paclitaxel.

15-05-2013

Cancer cell

In vivo RNAi screen for BMI1 targets identifies TGF-β/BMP-ER stress pathways as key regulators of neural- and malignant glioma-stem cell homeostasis.

13-05-2013

Nederlands tijdschrift voor geneeskunde

[Concomitant use of proton pump inhibitors and systemic corticosteroids].

10-05-2013

Proc Natl Acad Sci U S A: Proceedings of the National Academy of Siences of the United States of America

Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer

08-05-2013

Science (New York, N.Y.)

Heterogeneous differentiation patterns of individual CD8+ T cells.

03-05-2013

Nucleic acids research

A scale-space method for detecting recurrent DNA copy number changes with analytical false discovery rate control.

The Journal of urology

FDG-positron emission tomography/computerized tomography for monitoring the response of pelvic lymph node metastasis to neoadjuvant chemotherapy for bladder cancer.

International journal of radiation oncology, biology, physics

Hybrid registration of prostate and seminal vesicles for image guided radiation therapy.

Gynecologic oncology

Follow-up practice in endometrial cancer and the association with patient and hospital characteristics: a study from the population-based PROFILES registry.

CNS oncology

Targeting core (mutated) pathways of high-grade gliomas: challenges of intrinsic resistance and drug efflux.

European journal of cancer (Oxford, England : 1990)

Sildenafil is not a useful modulator of ABCB1 and ABCG2 mediated drug resistance in vivo.

Molecular pharmacology

Murine Oatp1a/1b uptake transporters control rosuvastatin systemic exposure without affecting its apparent liver exposure.