Publications

Cancer

The role of comprehensive cancer centers in survivorship care.

Clinical pharmacokinetics

Oral anticancer drugs: mechanisms of low bioavailability and strategies for improvement.

Breast cancer research and treatment

Platform comparisons for identification of breast cancers with a BRCA-like copy number profile.

Drug delivery and translational research

Pharmacokinetic evaluation of three oral formulations of docetaxel boosted with ritonavir: two single-drug formulations vs. a fixed-dose combination tablet.

Nature communications

Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin.

30-05-2013

The EMBO journal

The chromodomain helicase Chd4 is required for Polycomb-mediated inhibition of astroglial differentiation.

29-05-2013

Genome biology

DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus.

28-05-2013

British journal of cancer

Triple-negative breast cancer: BRCAness and concordance of clinical features with BRCA1-mutation carriers.

28-05-2013

Nature communications

Assembly of a π-π stack of ligands in the binding site of an acetylcholine-binding protein.

23-05-2013

PloS one

Analysis of tumor heterogeneity and cancer gene networks using deep sequencing of MMTV-induced mouse mammary tumors.

22-05-2013

PloS one

Intravital FRET imaging of tumor cell viability and mitosis during chemotherapy.

22-05-2013

The breast journal

Paclitaxel, carboplatin, and trastuzumab in a neo-adjuvant regimen for HER2-positive breast cancer.

21-05-2013

The oncologist

Concise drug review: azacitidine and decitabine.

15-05-2013

The breast journal

Major changes in chemotherapy regimens administered to breast cancer patients during 2000-2008 in the Netherlands.

15-05-2013

International journal of cancer

P-glycoprotein and cytochrome P450 3A act together in restricting the oral bioavailability of paclitaxel.

15-05-2013

Cancer cell

In vivo RNAi screen for BMI1 targets identifies TGF-β/BMP-ER stress pathways as key regulators of neural- and malignant glioma-stem cell homeostasis.

13-05-2013

Nederlands tijdschrift voor geneeskunde

[Concomitant use of proton pump inhibitors and systemic corticosteroids].

10-05-2013

Proc Natl Acad Sci U S A: Proceedings of the National Academy of Siences of the United States of America

Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer

08-05-2013

Science (New York, N.Y.)

Heterogeneous differentiation patterns of individual CD8+ T cells.

03-05-2013

Nucleic acids research

A scale-space method for detecting recurrent DNA copy number changes with analytical false discovery rate control.

The Journal of urology

FDG-positron emission tomography/computerized tomography for monitoring the response of pelvic lymph node metastasis to neoadjuvant chemotherapy for bladder cancer.

International journal of radiation oncology, biology, physics

Hybrid registration of prostate and seminal vesicles for image guided radiation therapy.

Gynecologic oncology

Follow-up practice in endometrial cancer and the association with patient and hospital characteristics: a study from the population-based PROFILES registry.

CNS oncology

Targeting core (mutated) pathways of high-grade gliomas: challenges of intrinsic resistance and drug efflux.

European journal of cancer (Oxford, England : 1990)

Sildenafil is not a useful modulator of ABCB1 and ABCG2 mediated drug resistance in vivo.

Molecular pharmacology

Murine Oatp1a/1b uptake transporters control rosuvastatin systemic exposure without affecting its apparent liver exposure.

Lung cancer (Amsterdam, Netherlands)

Improved identification of peripheral lung tumors by using diffuse reflectance and fluorescence spectroscopy.

Journal of cell science

UV-induced G2 checkpoint depends on p38 MAPK and minimal activation of ATR-Chk1 pathway.

European journal of cancer (Oxford, England : 1990)

Quantifying fatigue in (long-term) colorectal cancer survivors: a study from the population-based patient reported outcomes following initial treatment and long term evaluation of survivorship registry.

Communicative & integrative biology

Nuclear envelope-associated dynein cooperates with Eg5 to drive prophase centrosome separation.

Science (New York, N.Y.)

Deciphering the glycosylome of dystroglycanopathies using haploid screens for lassa virus entry.

26-04-2013

Frontiers in oncology

Loss of telomere protection: consequences and opportunities.

19-04-2013

The Journal of cell biology

Systematic dissection of dynein regulators in mitosis.

15-04-2013

Clinical cancer research : an official journal of the American Association for Cancer Research

Abcc4 together with abcb1 and abcg2 form a robust cooperative drug efflux system that restricts the brain entry of camptothecin analogues.

15-04-2013

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Quantification of cabazitaxel, its metabolite docetaxel and the determination of the demethylated metabolites RPR112698 and RPR123142 as docetaxel equivalents in human plasma by liquid chromatography-tandem mass spectrometry.

15-04-2013

Nature

Diverse and heritable lineage imprinting of early haematopoietic progenitors.

11-04-2013

The Journal of experimental medicine

Epithelial and dendritic cells in the thymic medulla promote CD4+Foxp3+ regulatory T cell development via the CD27-CD70 pathway.

08-04-2013

Investigational new drugs

Eribulin mesylate pharmacokinetics in patients with solid tumors receiving repeated oral ketoconazole.

Therapeutic drug monitoring

Quantification of sunitinib and N-desethyl sunitinib in human EDTA plasma by liquid chromatography coupled with electrospray ionization tandem mass spectrometry: validation and application in routine therapeutic drug monitoring.

Nature reviews. Nephrology

Cell-matrix adhesion of podocytes in physiology and disease.

Nature reviews. Molecular cell biology

Senescence: back to telomeres.

Current opinion in immunology

Human cancer regression antigens.

Endocrine-related cancer

Rising incidence, no change in survival and decreasing mortality from thyroid cancer in The Netherlands since 1989.

Current opinion in genetics & development

Chromatin organization: form to function.

Gynecologic oncology

The relationship of body mass index with quality of life among endometrial cancer survivors: a study from the population-based PROFILES registry.

Molecular oncology

Mouse models for lung cancer.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

Response to induction chemotherapy and surgery in non-organ confined bladder cancer: a single institution experience.

Molecular oncology

Genetically engineered mouse models of PI3K signaling in breast cancer.

The Netherlands journal of medicine

Recent advances towards the clinical application of DNA vaccines.