Publications

Cancer chemotherapy and pharmacology

Urinary and fecal excretion of topotecan in patients with malignant solid tumours.

01-07-2002

Cancer chemotherapy and pharmacology

A population analysis of the pharmacokinetics of Cremophor EL using nonlinear mixed-effect modelling.

01-07-2002

Proceedings of the National Academy of Sciences of the United States of America

Specificity and affinity motifs for Grb2 SH2-ligand interactions.

25-06-2002

Biochimica et biophysica acta

Polycomb repression: from cellular memory to cellular proliferation and cancer.

21-06-2002

The Journal of biological chemistry

Bcl-2 family member Bfl-1/A1 sequesters truncated bid to inhibit is collaboration with pro-apoptotic Bak or Bax.

21-06-2002

Methods in enzymology

Assays for gene silencing in yeast.

21-06-2002

Cell

Dot1p modulates silencing in yeast by methylation of the nucleosome core.

14-06-2002

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Phase I clinical and pharmacologic study of chronic oral administration of the farnesyl protein transferase inhibitor R115777 in advanced cancer.

01-06-2002

Novartis Foundation symposium

The 2.7 A structure of AChBP, homologue of the ligand-binding domain of the nicotinic acetylcholine receptor.

25-05-2002

Journal of immunology (Baltimore, Md. : 1950)

Optimizing the efficacy of epitope-directed DNA vaccination.

15-05-2002

Journal of immunology (Baltimore, Md. : 1950)

The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2.

15-05-2002

European journal of drug metabolism and pharmacokinetics

Evaluation of the bioequivalence of tablets and capsules containing the novel anticancer agent R115777 (Zarnestra) in patients with advanced solid tumors.

09-05-2002

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation

Assessing health status and quality-of-life instruments: attributes and review criteria.

01-05-2002

Cancer cell

Senescence: a companion in chemotherapy?

01-05-2002

Trends in immunology

Adoptive transfer of T-cell immunity.

01-05-2002

Fertility and sterility

A low number of retrieved oocytes at in vitro fertilization treatment is predictive of early menopause.

01-05-2002

Science (New York, N.Y.)

A system for stable expression of short interfering RNAs in mammalian cells.

19-04-2002

Cancer research

A mutation hot spot in the Bcrp1 (Abcg2) multidrug transporter in mouse cell lines selected for Doxorubicin resistance.

15-04-2002

Key

Anti-cancer drugs

Clinical pharmacology of the novel marine-derived anticancer agent Ecteinascidin 743 administered as a 1- and 3-h infusion in a phase I study.

01-04-2002

Nature reviews. Cancer

Conditional mouse models of sporadic cancer.

01-04-2002

Molecular cancer therapeutics

Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C.

01-04-2002

Cancer chemotherapy and pharmacology

Population pharmacokinetics of the novel anticancer agent KRN7000.

01-04-2002

Cancer cell

RUNX: a trilogy of cancer genes.

01-04-2002

Lancet (London, England)

Hypospadias in sons of women exposed to diethylstilbestrol in utero: a cohort study.

30-03-2002

Cancer letters

Convergence of mitogenic and DNA damage signaling in the G1 phase of the cell cycle.

28-03-2002

Nederlands tijdschrift voor geneeskunde

[The concomitant use of radiotherapy and chemotherapy for the treatment of solid malignant tumors].

16-03-2002

Cancer research

Noninvasive imaging of spontaneous retinoblastoma pathway-dependent tumors in mice.

15-03-2002

Genes & development

A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling.

15-03-2002

Journal of cell science

Association of the tetraspanin CD151 with the laminin-binding integrins alpha3beta1, alpha6beta1, alpha6beta4 and alpha7beta1 in cells in culture and in vivo.

15-03-2002

Genes to cells : devoted to molecular & cellular mechanisms

The FYVE domain in Smad anchor for receptor activation (SARA) is sufficient for localization of SARA in early endosomes and regulates TGF-beta/Smad signalling.

01-03-2002

Annals of oncology : official journal of the European Society for Medical Oncology

Relationship between exposure and toxicity in high-dose chemotherapy with cyclophosphamide, thiotepa and carboplatin.

01-03-2002

Cancer chemotherapy and pharmacology

Phase I and pharmacokinetic study of SPI-77, a liposomal encapsulated dosage form of cisplatin.

01-03-2002

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

Diagnosis and treatment of isolated neck metastases of adenocarcinomas.

01-03-2002

The Journal of biological chemistry

TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence.

22-02-2002

Biologicals : journal of the International Association of Biological Standardization

Circumventing T-cell tolerance to tumour antigens.

20-02-2002

Acta oncologica (Stockholm, Sweden)

Hypoxia and perfusion measurements in human tumors--initial experience with pimonidazole and IUdR.

16-02-2002

Acta oncologica (Stockholm, Sweden)

Radiation nephropathy--the link between functional damage and vascular mediated inflammatory and thrombotic changes.

16-02-2002

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Role of health-related quality of life in palliative chemotherapy treatment decisions.

15-02-2002

Cancer chemotherapy and pharmacology

Entrapment by Cremophor EL decreases the absorption of paclitaxel from the gut.

01-02-2002

Nature cell biology

A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence.

01-02-2002

Nature

Gene expression profiling predicts clinical outcome of breast cancer.

31-01-2002

The Journal of cell biology

Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits.

21-01-2002

Journal of immunology (Baltimore, Md. : 1950)

Can the low-avidity self-specific T cell repertoire be exploited for tumor rejection?

15-01-2002

Advances in experimental medicine and biology

The roles of P-glycoprotein and MRP1 in the blood-brain and blood-cerebrospinal fluid barriers.

05-01-2002

European journal of cancer (Oxford, England : 1990)

The combined use of radiotherapy and chemotherapy in the treatment of solid tumours.

01-01-2002

Anti-cancer drugs

Topoisomerase I levels in white blood cells of patients with ovarian cancer treated with paclitaxel-cisplatin-topotecan in a phase I study.

01-01-2002

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Increased risk of ischemic stroke after radiotherapy on the neck in patients younger than 60 years.

01-01-2002

The Journal of biological chemistry

Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3).

07-12-2001

Cancer chemotherapy and pharmacology

A comparison of limited sampling strategies for prediction of Ecteinascidin 743 clearance when administered as a 24-h infusion.

01-12-2001

Nature genetics

Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.

01-12-2001