Publications

International journal of radiation oncology, biology, physics

Dose-wall histograms and normalized dose-surface histograms for the rectum: a new method to analyze the dose distribution over the rectum in conformal radiotherapy.

Journal of cell science

Partial rescue of epithelial phenotype in integrin beta4 null mice by a keratin-5 promoter driven human integrin beta4 transgene.

The Journal of experimental medicine

Selective expansion of cross-reactive CD8(+) memory T cells by viral variants.

Mechanisms of development

In vivo analysis of Frat1 deficiency suggests compensatory activity of Frat3.

Biochimica et biophysica acta

CDK-independent activities of D type cyclins.

29-10-1999

Oncogene

Overexpression of Frat1 in transgenic mice leads to glomerulosclerosis and nephrotic syndrome, and provides direct evidence for the involvement of Frat1 in lymphoma progression.

28-10-1999

The Journal of cell biology

Binding of integrin alpha6beta4 to plectin prevents plectin association with F-actin but does not interfere with intermediate filament binding.

18-10-1999

Genes & development

Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF.

15-10-1999

Clinical cancer research : an official journal of the American Association for Cancer Research

Rapid esterase-sensitive breakdown of polysorbate 80 and its impact on the plasma pharmacokinetics of docetaxel and metabolites in mice.

01-10-1999

Proceedings of the National Academy of Sciences of the United States of America

Mice without phosphatidylcholine transfer protein have no defects in the secretion of phosphatidylcholine into bile or into lung airspaces.

28-09-1999

Oncogene

Developmental defects and tumor predisposition in Rb mutant mice.

20-09-1999

Nederlands tijdschrift voor geneeskunde

[Hyperthermic intra-peritoneal chemotherapy (HIPEC) in patients with peritoneal pseudomyxoma or peritoneal metastases of colorectal carcinoma; good preliminary results from the Netherlands Cancer Institute].

11-09-1999

British journal of cancer

Cremophor EL causes (pseudo-) non-linear pharmacokinetics of paclitaxel in patients.

01-09-1999

British journal of cancer

Evaluating the quality of life of cancer patients: assessments by patients, significant others, physicians and nurses.

01-09-1999

Cancer research

The mouse Bcrp1/Mxr/Abcp gene: amplification and overexpression in cell lines selected for resistance to topotecan, mitoxantrone, or doxorubicin.

01-09-1999

Proceedings of the National Academy of Sciences of the United States of America

Recycling MHC class I molecules and endosomal peptide loading.

31-08-1999

Cancer chemotherapy and pharmacology

Pharmacokinetics of paclitaxel administered in combination with cisplatin, etoposide and bleomycin in patients with advanced solid tumours.

14-08-1999

The EMBO journal

Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1

02-08-1999

Nature cell biology

Rac regulates phosphorylation of the myosin-II heavy chain, actinomyosin disassembly and cell spreading.

01-08-1999

European journal of drug metabolism and pharmacokinetics

Comparative open, randomized, cross-over bioequivalence study of two intravenous dexrazoxane formulations (Cardioxane and ICRF-187) in patients with advanced breast cancer, treated with 5-fluorouracil-doxorubicin-cyclophosphamide (FDC).

21-07-1999

Cellular immunology

Enrichment of an antigen-specific T cell response by retrovirally transduced human dendritic cells.

10-07-1999

Patient education and counseling

Psychosocial factors in the etiology of breast cancer: review of a popular link.

Immunity

Pre-TCR signaling and inactivation of p53 induces crucial cell survival pathways in pre-T cells.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

In vivo dosimetry during conformal radiotherapy: requirements for and findings of a routine procedure.

Pharmacological research

Pharmacokinetics of paclitaxel administered as a 3-hour or 96-hour infusion.

British journal of cancer

Oral topotecan: bioavailablity and effect of food co-administration.

BioEssays : news and reviews in molecular, cellular and developmental biology

Integrins: alternative splicing as a mechanism to regulate ligand binding and integrin signaling events.

Current opinion in genetics & development

The trithorax-group and polycomb-group chromatin modifiers: implications for disease.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Phase I and pharmacokinetic study of irinotecan administered as a low-dose, continuous intravenous infusion over 14 days in patients with malignant solid tumors.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Phase I and pharmacokinetic study of a daily times 5 short intravenous infusion schedule of 9-aminocamptothecin in a colloidal dispersion formulation in patients with advanced solid tumors.

Cancer research

Alkyl-lysophospholipids activate the SAPK/JNK pathway and enhance radiation-induced apoptosis.

15-05-1999

The Journal of biological chemistry

Common regulation of apoptosis signaling induced by CD95 and the DNA-damaging stimuli etoposide and gamma-radiation downstream from caspase-8 activation.

14-05-1999

Cancer chemotherapy and pharmacology

Paclitaxel in the treatment of human immunodeficiency virus 1-associated Kaposi's sarcoma--drug-drug interactions with protease inhibitors and a nonnucleoside reverse transcriptase inhibitor: a case report study.

13-05-1999

Cancer

The development of a prognostic score for patients with parotid carcinoma.

01-05-1999

British journal of pharmacology

Role of blood-brain barrier P-glycoprotein in limiting brain accumulation and sedative side-effects of asimadoline, a peripherally acting analgaesic drug.

01-05-1999

Trends in genetics : TIG

Mouse models for cancer at center stage. AACR special meeting: Cancer Biology and the Mutant Mouse: New Methods, New Models, New Insights, Keystone Colorado, USA, 31 January-5 February 1999.

01-05-1999

Journal of chromatography. B, Biomedical sciences and applications

Quantification of topotecan and its metabolite N-desmethyltopotecan in human plasma, urine and faeces by high-performance liquid chromatographic methods.

30-04-1999

Advanced drug delivery reviews

P-Glycoprotein, a gatekeeper in the blood-brain barrier.

05-04-1999

European journal of immunology

Systemic T cell expansion during localized viral infection.

Immunology today

Turning the immune system on.

Cancer treatment reviews

Clinical pharmacology of anticancer agents in relation to formulations and administration routes.

Cancer research

Identification and characterization of collaborating oncogenes in compound mutant mice.

The Journal of clinical investigation

Ordering of ceramide formation, caspase activation, and mitochondrial changes during CD95- and DNA damage-induced apoptosis.

Seminars in cell & developmental biology

Cellular memory of transcriptional states by Polycomb-group proteins.

The Journal of pharmacology and experimental therapeutics

Comparative pharmacokinetics of vinblastine after a 96-hour continuous infusion in wild-type mice and mice lacking mdr1a P-glycoprotein.

Cancer chemotherapy and pharmacology

A single 24-hour plasma sample does not predict the carboplatin AUC from carboplatin-paclitaxel combinations or from a high-dose carboplatin-thiotepa-cyclophosphamide regimen.