Publications

Cancer investigation

Modulation of oral drug bioavailability: from preclinical mechanism to therapeutic application.

Cancer chemotherapy and pharmacology

Aprepitant inhibits cyclophosphamide bioactivation and thiotepa metabolism.

Cancer chemotherapy and pharmacology

Absence of N-linked glycosylation does not affect plasma membrane localization of breast cancer resistance protein (BCRP/ABCG2).

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Quality-of-life effects of prophylactic salpingo-oophorectomy versus gynecologic screening among women at increased risk of hereditary ovarian cancer.

Investigational new drugs

Trabectedin (Yondelis, formerly ET-743), a mass balance study in patients with advanced cancer.

Cell

The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling.

23-09-2005

International journal of cancer

MRP2 (ABCC2) transports taxanes and confers paclitaxel resistance and both processes are stimulated by probenecid.

20-09-2005

Cancer research

Mice expressing a mammary gland-specific R270H mutation in the p53 tumor suppressor gene mimic human breast cancer development

15-09-2005

Menopause (New York, N.Y.)

Are cause of subfertility and in vitro fertilization treatment risk factors for an earlier start of menopause?

08-09-2005

Cancer immunology, immunotherapy : CII

Prolonged low dose IL-2 and thalidomide in progressive metastatic renal cell carcinoma with concurrent radiotherapy to bone and/or soft tissue metastasis: a phase II study.

Genome research

Genome-wide HP1 binding in Drosophila: developmental plasticity and genomic targeting signals.

EMBO reports

Ablation of the spindle assembly checkpoint by a compound targeting Mps1.

Journal of pharmaceutical and biomedical analysis

Development and validation of an LC-UV method for the quantification and purity determination of the novel anticancer agent C1311 and its pharmaceutical dosage form.

The oncologist

Current knowledge and future directions of the selective epidermal growth factor receptor inhibitors erlotinib (Tarceva) and gefitinib (Iressa).

Stem cells (Dayton, Ohio)

Contribution of the ABC transporters Bcrp1 and Mdr1a/1b to the side population phenotype in mammary gland and bone marrow of mice.

Cancer chemotherapy and pharmacology

Metabolism of docetaxel in mice.

The oncologist

Development of farnesyl transferase inhibitors: a review.

Nederlands tijdschrift voor geneeskunde

[Trends and variation in breast conserving surgery in the southeast and east of the Netherlands over the period 1990-2002].

27-08-2005

Cold Spring Harbor symposia on quantitative biology

Functional identification of cancer-relevant genes through large-scale RNA interference screens in mammalian cells.

25-08-2005

Cold Spring Harbor symposia on quantitative biology

Emerging roles of Polycomb silencing in X-inactivation and stem cell maintenance.

25-08-2005

Cancer research

The neurotrophic receptor TrkB in anoikis resistance and metastasis: a perspective.

15-08-2005

Nature

BRAFE600-associated senescence-like cell cycle arrest of human naevi.

04-08-2005

Analytical and bioanalytical chemistry

Determination of oxaliplatin in human plasma and plasma ultrafiltrate by graphite-furnace atomic-absorption spectrometry.

Journal of immunology (Baltimore, Md. : 1950)

During viral infection of the respiratory tract, CD27, 4-1BB, and OX40 collectively determine formation of CD8+ memory T cells and their capacity for secondary expansion.

Molecular and cellular biology

p53-Dependent regulation of Cdc6 protein stability controls cellular proliferation.

European journal of cancer (Oxford, England : 1990)

Effective palliation by low dose local radiotherapy for recurrent and/or chemotherapy refractory non-follicular lymphoma patients.

Investigational new drugs

Human metabolism of [(14)C]indisulam following i.v. infusion in cancer patients.

Investigational new drugs

Tumor and normal tissue pharmacokinetics of perifosine, an oral anti-cancer alkylphospholipid.

Cell cycle (Georgetown, Tex.)

Re-evaluating the role of Frat in Wnt-signal transduction.

Anti-cancer drugs

Compatibility and stability of Imexon in infusion devices and its in vitro biocompatibility.

Current opinion in immunology

MHC multimer technology: current status and future prospects.

Nature medicine

A rapid and potent DNA vaccination strategy defined by in vivo monitoring of antigen expression.

The Journal of biological chemistry

Crystal structure of acetylcholine-binding protein from Bulinus truncatus reveals the conserved structural scaffold and sites of variation in nicotinic acetylcholine receptors.

15-07-2005

Journal of pharmaceutical and biomedical analysis

LC-UV method development and validation for the investigational anticancer agent imexon and identification of its degradation products.

15-07-2005

International journal of radiation oncology, biology, physics

Thymidine analogues to assess microperfusion in human tumors.

15-07-2005

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Optimal locoregional treatment in gastric cancer.

10-07-2005

Rapid communications in mass spectrometry : RCM

Quantitative analysis of the farnesyl transferase inhibitor lonafarnib (Sarasartrade mark, SCH66336) in human plasma using high-performance liquid chromatography coupled with tandem mass spectrometry.

05-07-2005

International journal of radiation oncology, biology, physics

Pulmonary function changes after radiotherapy in non-small-cell lung cancer patients with long-term disease-free survival.

Cancer immunology, immunotherapy : CII

A phase-II study of pegylated interferon alfa-2b for patients with metastatic renal cell carcinoma and removal of the primary tumor.

Nature structural & molecular biology

Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an alpha-conotoxin PnIA variant.

Head & neck

Hypoxia in head and neck cancer: how much, how important?

Drug metabolism and disposition: the biological fate of chemicals

Midazolam and cyclosporin a metabolism in transgenic mice with liver-specific expression of human CYP3A4.

European journal of cancer (Oxford, England : 1990)

Standardised FDG uptake: a prognostic factor for inoperable non-small cell lung cancer.