Publications

Genome research

Genome-wide HP1 binding in Drosophila: developmental plasticity and genomic targeting signals.

EMBO reports

Ablation of the spindle assembly checkpoint by a compound targeting Mps1.

Journal of pharmaceutical and biomedical analysis

Development and validation of an LC-UV method for the quantification and purity determination of the novel anticancer agent C1311 and its pharmaceutical dosage form.

The oncologist

Current knowledge and future directions of the selective epidermal growth factor receptor inhibitors erlotinib (Tarceva) and gefitinib (Iressa).

Stem cells (Dayton, Ohio)

Contribution of the ABC transporters Bcrp1 and Mdr1a/1b to the side population phenotype in mammary gland and bone marrow of mice.

Cancer chemotherapy and pharmacology

Metabolism of docetaxel in mice.

The oncologist

Development of farnesyl transferase inhibitors: a review.

Nederlands tijdschrift voor geneeskunde

[Trends and variation in breast conserving surgery in the southeast and east of the Netherlands over the period 1990-2002].

27-08-2005

Cold Spring Harbor symposia on quantitative biology

Functional identification of cancer-relevant genes through large-scale RNA interference screens in mammalian cells.

25-08-2005

Cold Spring Harbor symposia on quantitative biology

Emerging roles of Polycomb silencing in X-inactivation and stem cell maintenance.

25-08-2005

Cancer research

The neurotrophic receptor TrkB in anoikis resistance and metastasis: a perspective.

15-08-2005

Nature

BRAFE600-associated senescence-like cell cycle arrest of human naevi.

04-08-2005

Analytical and bioanalytical chemistry

Determination of oxaliplatin in human plasma and plasma ultrafiltrate by graphite-furnace atomic-absorption spectrometry.

Journal of immunology (Baltimore, Md. : 1950)

During viral infection of the respiratory tract, CD27, 4-1BB, and OX40 collectively determine formation of CD8+ memory T cells and their capacity for secondary expansion.

Molecular and cellular biology

p53-Dependent regulation of Cdc6 protein stability controls cellular proliferation.

European journal of cancer (Oxford, England : 1990)

Effective palliation by low dose local radiotherapy for recurrent and/or chemotherapy refractory non-follicular lymphoma patients.

Investigational new drugs

Human metabolism of [(14)C]indisulam following i.v. infusion in cancer patients.

Investigational new drugs

Tumor and normal tissue pharmacokinetics of perifosine, an oral anti-cancer alkylphospholipid.

Cell cycle (Georgetown, Tex.)

Re-evaluating the role of Frat in Wnt-signal transduction.

Anti-cancer drugs

Compatibility and stability of Imexon in infusion devices and its in vitro biocompatibility.

Current opinion in immunology

MHC multimer technology: current status and future prospects.

Nature medicine

A rapid and potent DNA vaccination strategy defined by in vivo monitoring of antigen expression.

The Journal of biological chemistry

Crystal structure of acetylcholine-binding protein from Bulinus truncatus reveals the conserved structural scaffold and sites of variation in nicotinic acetylcholine receptors.

15-07-2005

Journal of pharmaceutical and biomedical analysis

LC-UV method development and validation for the investigational anticancer agent imexon and identification of its degradation products.

15-07-2005

International journal of radiation oncology, biology, physics

Thymidine analogues to assess microperfusion in human tumors.

15-07-2005

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Optimal locoregional treatment in gastric cancer.

10-07-2005

Rapid communications in mass spectrometry : RCM

Quantitative analysis of the farnesyl transferase inhibitor lonafarnib (Sarasartrade mark, SCH66336) in human plasma using high-performance liquid chromatography coupled with tandem mass spectrometry.

05-07-2005

International journal of radiation oncology, biology, physics

Pulmonary function changes after radiotherapy in non-small-cell lung cancer patients with long-term disease-free survival.

Cancer immunology, immunotherapy : CII

A phase-II study of pegylated interferon alfa-2b for patients with metastatic renal cell carcinoma and removal of the primary tumor.

Nature structural & molecular biology

Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an alpha-conotoxin PnIA variant.

Head & neck

Hypoxia in head and neck cancer: how much, how important?

Drug metabolism and disposition: the biological fate of chemicals

Midazolam and cyclosporin a metabolism in transgenic mice with liver-specific expression of human CYP3A4.

European journal of cancer (Oxford, England : 1990)

Standardised FDG uptake: a prognostic factor for inoperable non-small cell lung cancer.

Genome biology

Histone modifications: from genome-wide maps to functional insights.

18-06-2005

Cell

Stem cells for lung cancer?

17-06-2005

Cell

A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity.

17-06-2005

Genes & development

Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice.

15-06-2005

The Journal of biological chemistry

Modeling and experimental validation of the binary complex of the plectin actin-binding domain and the first pair of fibronectin type III (FNIII) domains of the beta4 integrin.

10-06-2005

The Journal of biological chemistry

Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate.

03-06-2005

Experimental lung research

Lung tumor location and lymphocyte infiltration in mice are genetically determined.

Cancer cell

A functional approach to questions about life, death, and phosphorylation.

Current opinion in immunology

CD27 and CD70 in T cell and B cell activation.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

The prognostic significance of axillary lymph-node micrometastases in breast cancer patients.

Current opinion in microbiology

Presenting antigen presentation in living cells using biophysical techniques.

Nature genetics

Mapping of genetic and epigenetic regulatory networks using microarrays.

European journal of cancer (Oxford, England : 1990)

Increased risk of breast cancer development after diagnosis of salivary gland tumour.