Publications

Structure (London, England : 1993)

Crystal structure of the targeting endonuclease of the human LINE-1 retrotransposon.

Genes & development

The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote.

Current opinion in cell biology

Polycomb complexes and silencing mechanisms.

Cancer cell

Tamoxifen resistance by a conformational arrest of the estrogen receptor alpha after PKA activation in breast cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research

A Phase I and pharmacological study with imidazolium-trans-DMSO-imidazole-tetrachlororuthenate, a novel ruthenium anticancer agent.

Science (New York, N.Y.)

Antigen bias in T cell cross-priming.

28-05-2004

Clinical cancer research : an official journal of the American Association for Cancer Research

A Phase I and pharmacological study of the platinum polymer AP5280 given as an intravenous infusion once every 3 weeks in patients with solid tumors.

15-05-2004

European journal of cancer (Oxford, England : 1990)

Improved penetration of docetaxel into the brain by co-administration of inhibitors of P-glycoprotein.

01-05-2004

Cell cycle (Georgetown, Tex.)

Unraveling human tumor suppressor pathways: a tale of the INK4A locus.

01-05-2004

British journal of cancer

Clinical outcome of prophylactic oophorectomy in BRCA1/BRCA2 mutation carriers and events during follow-up.

19-04-2004

The New England journal of medicine

Good news for gene therapy.

15-04-2004

Clinical cancer research : an official journal of the American Association for Cancer Research

Bayesian pharmacokinetically guided dosing of paclitaxel in patients with non-small cell lung cancer.

Breast cancer research and treatment

Insulin-like growth factor (IGF)-system mRNA quantities in normal and tumor breast tissue of women with sporadic and familial breast cancer risk.

Investigational new drugs

Pharmacokinetic drug-drug interaction of the novel anticancer agent E7070 and acenocoumarol.

Journal of pharmacokinetics and pharmacodynamics

Integrated Population Pharmacokinetic Model of both cyclophosphamide and thiotepa suggesting a mutual drug-drug interaction.

Journal of mass spectrometry : JMS

Simple and sensitive liquid chromatographic quantitative analysis of the novel marine anticancer drug Yondelis (ET-743, trabectedin) in human plasma using column switching and tandem mass spectrometric detection.

Human reproduction (Oxford, England)

The number of retrieved oocytes does not decrease during consecutive gonadotrophin-stimulated IVF cycles.

Biophysical journal

Correcting confocal acquisition to optimize imaging of fluorescence resonance energy transfer by sensitized emission.

Neuron

Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures.

25-03-2004

Nature

A large-scale RNAi screen in human cells identifies new components of the p53 pathway.

25-03-2004

Nederlands tijdschrift voor geneeskunde

[Genetic research with stored human tissue: a coding procedure with optimal use of information and protection of privacy].

20-03-2004

Cancer research

Human telomerase reverse transcriptase-transduced human cytotoxic T cells suppress the growth of human melanoma in immunodeficient mice.

15-03-2004

The Journal of biological chemistry

High incidence of thymic epithelial tumors in E2F2 transgenic mice.

12-03-2004

Journal of mass spectrometry : JMS

Quantitative analysis of the novel anticancer drug ABT-518, a matrix metalloproteinase inhibitor, plus the screening of six metabolites in human plasma using high-performance liquid chromatography coupled with electrospray tandem mass spectrometry.

01-03-2004

Journal of mass spectrometry : JMS

Simultaneous quantification of cyclophosphamide, 4-hydroxycyclophosphamide, N,N',N"-triethylenethiophosphoramide (thiotepa) and N,N',N"-triethylenephosphoramide (tepa) in human plasma by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.

01-03-2004

Molecular biology of the cell

Role of binding of plectin to the integrin beta4 subunit in the assembly of hemidesmosomes.

01-03-2004

British journal of cancer

N-hexanoyl-sphingomyelin potentiates in vitro doxorubicin cytotoxicity by enhancing its cellular influx.

23-02-2004

Journal of immunology (Baltimore, Md. : 1950)

The impact of self-tolerance on the polyclonal CD8+ T cell repertoire.

15-02-2004

Cancer chemotherapy and pharmacology

The influence of the P-glycoprotein inhibitor zosuquidar trihydrochloride (LY335979) on the brain penetration of paclitaxel in mice.

Medical physics

Leaf trajectory verification during dynamic intensity modulated radiotherapy using an amorphous silicon flat panel imager.

Cancer causes & control : CCC

A cohort study of cancer mortality among Biology Research Laboratory workers in The Netherlands.

Medical physics

Dose-response and ghosting effects of an amorphous silicon electronic portal imaging device.

Clinical pharmacokinetics

Population pharmacokinetics and pharmacodynamics of mitomycin during intraoperative hyperthermic intraperitoneal chemotherapy.

30-01-2004

Genome research

A whole-genome mouse BAC microarray with 1-Mb resolution for analysis of DNA copy number changes by array comparative genomic hybridization

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Differentiation-associated staining with anti-pimonidazole antibodies in head and neck tumors.

Handbook of experimental pharmacology

Hemidesmosomes: molecular organization and their importance for cell adhesion and disease.

Analytical biochemistry

Development and validation of a method to determine the unbound paclitaxel fraction in human plasma.

The Journal of pharmacology and experimental therapeutics

Pharmacological and physiological functions of the polyspecific organic cation transporters: OCT1, 2, and 3 (SLC22A1-3).

Radiation research

Identification of differentially expressed genes in mouse kidney after irradiation using microarray analysis.

Breast cancer research and treatment

Excess risk for contralateral breast cancer in CHEK2*1100delC germline mutation carriers.