Publications

Cancer treatment reviews

Modulation of the blood-brain barrier in oncology: therapeutic opportunities for the treatment of brain tumours?

Investigational new drugs

Efficacy of novel P-glycoprotein inhibitors to increase the oral uptake of paclitaxel in mice.

Cell death and differentiation

Mechanism of action of Drosophila Reaper in mammalian cells: Reaper globally inhibits protein synthesis and induces apoptosis independent of mitochondrial permeability.

The Lancet. Oncology

Drug interactions in oncology.

British journal of cancer

Trends in the usage of adjuvant systemic therapy for breast cancer in the Netherlands and its effect on mortality.

19-07-2004

Nederlands tijdschrift voor geneeskunde

[Methods and results of in-vitro fertilisation in the Netherlands in the years 1983-1994].

17-07-2004

Clinical cancer research : an official journal of the American Association for Cancer Research

On the role of melanoma-specific CD8+ T-cell immunity in disease progression of advanced-stage melanoma patients.

15-07-2004

International journal of pharmaceutics

2-Hydroxypropyl-beta-cyclodextrin extracts 2-phenylphenol from silicone tubing.

08-07-2004

Nederlands tijdschrift voor geneeskunde

[Young adults with Ewing's sarcoma].

03-07-2004

The Journal of biological chemistry

Requirement for aspartate-cleaved bid in apoptosis signaling by DNA-damaging anti-cancer regimens.

02-07-2004

Biomedical chromatography : BMC

Switching from an analogous to a stable isotopically labeled internal standard for the LC-MS/MS quantitation of the novel anticancer drug Kahalalide F significantly improves assay performance.

Clinical cancer research : an official journal of the American Association for Cancer Research

Predicting early failure after adjuvant chemotherapy in high-risk breast cancer patients with extensive lymph node involvement.

European journal of cancer (Oxford, England : 1990)

Staging in patients with locoregionally recurrent breast cancer: current practice and prospects for positron emission tomography.

International journal of radiation oncology, biology, physics

In vivo imaging of radiation-induced apoptosis in follicular lymphoma patients.

Biomedical chromatography : BMC

A more sensitive MS detector does not obviously lead to a more sensitive assay: experiences with ES-285.

Cancer chemotherapy and pharmacology

Cytotoxicity of the organic ruthenium anticancer drug Nami-A is correlated with DNA binding in four different human tumor cell lines.

Molecular and cellular biology

Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors.

Rapid communications in mass spectrometry : RCM

Quantitative analysis of D-24851, a novel anticancer agent, in human plasma and urine by liquid chromatography coupled with tandem mass spectrometry.

25-06-2004

The Journal of biological chemistry

Characterization and functional analysis of the murine Frat2 gene.

25-06-2004

Oncogene

An in vivo functional genetic screen reveals a role for the TRK-T3 oncogene in tumor progression.

24-06-2004

The Biochemical journal

Optimizing RNA interference for application in mammalian cells.

15-06-2004

Journal of immunology (Baltimore, Md. : 1950)

CD27 is acquired by primed B cells at the centroblast stage and promotes germinal center formation.

15-06-2004

British journal of cancer

Phase I and pharmacokinetic study of the combination of topotecan and ifosfamide administered intravenously every 3 weeks.

14-06-2004

Journal of the American Geriatrics Society

Antihypertensive medications and differences in muscle mass in older persons: the Health, Aging and Body Composition Study.

Structure (London, England : 1993)

Crystal structure of the targeting endonuclease of the human LINE-1 retrotransposon.

Genes & development

The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote.

Current opinion in cell biology

Polycomb complexes and silencing mechanisms.

Cancer cell

Tamoxifen resistance by a conformational arrest of the estrogen receptor alpha after PKA activation in breast cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research

A Phase I and pharmacological study with imidazolium-trans-DMSO-imidazole-tetrachlororuthenate, a novel ruthenium anticancer agent.

Science (New York, N.Y.)

Antigen bias in T cell cross-priming.

28-05-2004

Clinical cancer research : an official journal of the American Association for Cancer Research

A Phase I and pharmacological study of the platinum polymer AP5280 given as an intravenous infusion once every 3 weeks in patients with solid tumors.

15-05-2004

European journal of cancer (Oxford, England : 1990)

Improved penetration of docetaxel into the brain by co-administration of inhibitors of P-glycoprotein.

01-05-2004

Cell cycle (Georgetown, Tex.)

Unraveling human tumor suppressor pathways: a tale of the INK4A locus.

01-05-2004

British journal of cancer

Clinical outcome of prophylactic oophorectomy in BRCA1/BRCA2 mutation carriers and events during follow-up.

19-04-2004

The New England journal of medicine

Good news for gene therapy.

15-04-2004

Clinical cancer research : an official journal of the American Association for Cancer Research

Bayesian pharmacokinetically guided dosing of paclitaxel in patients with non-small cell lung cancer.

Breast cancer research and treatment

Insulin-like growth factor (IGF)-system mRNA quantities in normal and tumor breast tissue of women with sporadic and familial breast cancer risk.

Investigational new drugs

Pharmacokinetic drug-drug interaction of the novel anticancer agent E7070 and acenocoumarol.

Journal of pharmacokinetics and pharmacodynamics

Integrated Population Pharmacokinetic Model of both cyclophosphamide and thiotepa suggesting a mutual drug-drug interaction.