Publications

Breast cancer research and treatment

Insulin-like growth factor (IGF)-system mRNA quantities in normal and tumor breast tissue of women with sporadic and familial breast cancer risk.

Investigational new drugs

Pharmacokinetic drug-drug interaction of the novel anticancer agent E7070 and acenocoumarol.

Journal of pharmacokinetics and pharmacodynamics

Integrated Population Pharmacokinetic Model of both cyclophosphamide and thiotepa suggesting a mutual drug-drug interaction.

Journal of mass spectrometry : JMS

Simple and sensitive liquid chromatographic quantitative analysis of the novel marine anticancer drug Yondelis (ET-743, trabectedin) in human plasma using column switching and tandem mass spectrometric detection.

Human reproduction (Oxford, England)

The number of retrieved oocytes does not decrease during consecutive gonadotrophin-stimulated IVF cycles.

Biophysical journal

Correcting confocal acquisition to optimize imaging of fluorescence resonance energy transfer by sensitized emission.

Neuron

Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures.

25-03-2004

Nature

A large-scale RNAi screen in human cells identifies new components of the p53 pathway.

25-03-2004

Nederlands tijdschrift voor geneeskunde

[Genetic research with stored human tissue: a coding procedure with optimal use of information and protection of privacy].

20-03-2004

Cancer research

Human telomerase reverse transcriptase-transduced human cytotoxic T cells suppress the growth of human melanoma in immunodeficient mice.

15-03-2004

The Journal of biological chemistry

High incidence of thymic epithelial tumors in E2F2 transgenic mice.

12-03-2004

Journal of mass spectrometry : JMS

Quantitative analysis of the novel anticancer drug ABT-518, a matrix metalloproteinase inhibitor, plus the screening of six metabolites in human plasma using high-performance liquid chromatography coupled with electrospray tandem mass spectrometry.

01-03-2004

Journal of mass spectrometry : JMS

Simultaneous quantification of cyclophosphamide, 4-hydroxycyclophosphamide, N,N',N"-triethylenethiophosphoramide (thiotepa) and N,N',N"-triethylenephosphoramide (tepa) in human plasma by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.

01-03-2004

Molecular biology of the cell

Role of binding of plectin to the integrin beta4 subunit in the assembly of hemidesmosomes.

01-03-2004

British journal of cancer

N-hexanoyl-sphingomyelin potentiates in vitro doxorubicin cytotoxicity by enhancing its cellular influx.

23-02-2004

Journal of immunology (Baltimore, Md. : 1950)

The impact of self-tolerance on the polyclonal CD8+ T cell repertoire.

15-02-2004

Cancer chemotherapy and pharmacology

The influence of the P-glycoprotein inhibitor zosuquidar trihydrochloride (LY335979) on the brain penetration of paclitaxel in mice.

Medical physics

Leaf trajectory verification during dynamic intensity modulated radiotherapy using an amorphous silicon flat panel imager.

Cancer causes & control : CCC

A cohort study of cancer mortality among Biology Research Laboratory workers in The Netherlands.

Medical physics

Dose-response and ghosting effects of an amorphous silicon electronic portal imaging device.

Clinical pharmacokinetics

Population pharmacokinetics and pharmacodynamics of mitomycin during intraoperative hyperthermic intraperitoneal chemotherapy.

30-01-2004

Genome research

A whole-genome mouse BAC microarray with 1-Mb resolution for analysis of DNA copy number changes by array comparative genomic hybridization

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Differentiation-associated staining with anti-pimonidazole antibodies in head and neck tumors.

Handbook of experimental pharmacology

Hemidesmosomes: molecular organization and their importance for cell adhesion and disease.

Analytical biochemistry

Development and validation of a method to determine the unbound paclitaxel fraction in human plasma.

The Journal of pharmacology and experimental therapeutics

Pharmacological and physiological functions of the polyspecific organic cation transporters: OCT1, 2, and 3 (SLC22A1-3).

Radiation research

Identification of differentially expressed genes in mouse kidney after irradiation using microarray analysis.

Breast cancer research and treatment

Excess risk for contralateral breast cancer in CHEK2*1100delC germline mutation carriers.

Proceedings of the National Academy of Sciences of the United States of America

Gene expression profiles of primary breast tumors maintained in distant metastases.

23-12-2003

Journal of chromatography. A

Development and validation of a liquid chromatography-ultraviolet absorbance detection assay using derivatisation for the novel marine anticancer agent ES-285 x HCl [(2S,3R)-2-amino-3-octadecanol hydrochloride] and its pharmaceutical dosage form.

12-12-2003

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Bioanalysis of zosuquidar trihydrochloride (LY335979) in small volumes of human and murine plasma by ion-pairing reversed-phase high-performance liquid chromatography.

05-12-2003

Apoptosis : an international journal on programmed cell death

The anti-cancer drug etoposide can induce caspase-8 processing and apoptosis in the absence of CD95 receptor-ligand interaction.

04-12-2003

The Journal of pathology

Integrins in regulation of tissue development and function.

01-12-2003

Genomics

Quantitative comparison of cDNA-AFLP, microarrays, and GeneChip expression data in Saccharomyces cerevisiae.

01-12-2003

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Thallium-201-chloride scintigraphy in staging and monitoring radiotherapy response in follicular lymphoma patients.

01-12-2003

Genes & development

Distinct HP1 and Su(var)3-9 complexes bind to sets of developmentally coexpressed genes depending on chromosomal location.

15-11-2003

The Journal of experimental medicine

CD27 promotes survival of activated T cells and complements CD28 in generation and establishment of the effector T cell pool.

03-11-2003

British journal of cancer

P-glycoprotein and Mrp1 collectively protect the bone marrow from vincristine-induced toxicity in vivo.

03-11-2003

Cancer research

The generation of a conditional reporter that enables bioluminescence imaging of Cre/loxP-dependent tumorigenesis in mice.

01-11-2003

Molecular and cellular biology

Deficiency in the organic cation transporters 1 and 2 (Oct1/Oct2 [Slc22a1/Slc22a2]) in mice abolishes renal secretion of organic cations.

01-11-2003

The Journal of biological chemistry

Calcium signaling regulates translocation and activation of Rac.

10-10-2003

Cancer research

The breast cancer resistance protein (Bcrp1/Abcg2) restricts exposure to the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.

Nature reviews. Cancer

New tools for functional mammalian cancer genetics.

Drug development and industrial pharmacy

Pharmaceutical development of a parenteral lyophilized formulation of the investigational polymer-conjugated platinum anticancer agent AP 5280.

Cancer cell

The tumor-suppressive functions of the human INK4A locus.

Molecular biology of the cell

Specificity of binding of the plectin actin-binding domain to beta4 integrin.