Publications

Cancer immunology, immunotherapy : CII

A phase-II study of pegylated interferon alfa-2b for patients with metastatic renal cell carcinoma and removal of the primary tumor.

Nature structural & molecular biology

Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an alpha-conotoxin PnIA variant.

Head & neck

Hypoxia in head and neck cancer: how much, how important?

Drug metabolism and disposition: the biological fate of chemicals

Midazolam and cyclosporin a metabolism in transgenic mice with liver-specific expression of human CYP3A4.

European journal of cancer (Oxford, England : 1990)

Standardised FDG uptake: a prognostic factor for inoperable non-small cell lung cancer.

Genome biology

Histone modifications: from genome-wide maps to functional insights.

18-06-2005

Cell

Stem cells for lung cancer?

17-06-2005

Cell

A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity.

17-06-2005

Genes & development

Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice.

15-06-2005

The Journal of biological chemistry

Modeling and experimental validation of the binary complex of the plectin actin-binding domain and the first pair of fibronectin type III (FNIII) domains of the beta4 integrin.

10-06-2005

The Journal of biological chemistry

Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate.

03-06-2005

Experimental lung research

Lung tumor location and lymphocyte infiltration in mice are genetically determined.

Cancer cell

A functional approach to questions about life, death, and phosphorylation.

Current opinion in immunology

CD27 and CD70 in T cell and B cell activation.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

The prognostic significance of axillary lymph-node micrometastases in breast cancer patients.

Current opinion in microbiology

Presenting antigen presentation in living cells using biophysical techniques.

Nature genetics

Mapping of genetic and epigenetic regulatory networks using microarrays.

European journal of cancer (Oxford, England : 1990)

Increased risk of breast cancer development after diagnosis of salivary gland tumour.

Investigational new drugs

Semi-physiological model describing the hematological toxicity of the anti-cancer agent indisulam.

Therapeutic drug monitoring

Sparse sampling design for therapeutic drug monitoring of sequentially administered cyclophosphamide, thiotepa, and carboplatin (CTC).

Biomedical chromatography : BMC

Quantitative analysis of docetaxel in human plasma using liquid chromatography coupled with tandem mass spectrometry.

Proceedings of the National Academy of Sciences of the United States of America

Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase.

24-05-2005

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Changes in gene expression associated with response to neoadjuvant chemotherapy in breast cancer.

20-05-2005

Proceedings of the National Academy of Sciences of the United States of America

Mice lacking multidrug resistance protein 3 show altered morphine pharmacokinetics and morphine-6-glucuronide antinociception.

17-05-2005

American journal of epidemiology

Validity of self-reported causes of subfertility.

15-05-2005

The Journal of cell biology

Integrins control motile strategy through a Rho-cofilin pathway.

09-05-2005

Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology

Whole-genome views of chromatin structure.

04-05-2005

The EMBO journal

PIP2 signaling in lipid domains: a critical re-evaluation.

04-05-2005

Cancer chemotherapy and pharmacology

Pharmacokinetics of low-dose doxorubicin and metabolites in patients with AIDS-related Kaposi sarcoma.

Journal of pharmaceutical sciences

Pharmaceutical development of a lyophilised dosage form for the investigational anticancer agent Imexon using dimethyl sulfoxide as solubilising and stabilising agent.

Drug metabolism and disposition: the biological fate of chemicals

Transport of anthelmintic benzimidazole drugs by breast cancer resistance protein (BCRP/ABCG2).

Molecular pharmacology

Sex-dependent expression and activity of the ATP-binding cassette transporter breast cancer resistance protein (BCRP/ABCG2) in liver.

Cancer chemotherapy and pharmacology

Significant induction of cyclophosphamide and thiotepa metabolism by phenytoin.

Pharmacological research

Hepatotoxicity and metabolism of trabectedin: a literature review.

Molecular pharmacology

The breast cancer resistance protein (BCRP/ABCG2) affects pharmacokinetics, hepatobiliary excretion, and milk secretion of the antibiotic nitrofurantoin.

Oncogene

Getting in and out of mitosis with Polo-like kinase-1.

18-04-2005

American journal of pharmacogenomics : genomics-related research in drug development and clinical practice

Detection of single nucleotide polymorphisms in the ABCG2 gene in a Dutch population.

09-04-2005

Medical physics

Respiratory correlated cone beam CT.

01-04-2005

Cancer research

The effect of Bcrp1 (Abcg2) on the in vivo pharmacokinetics and brain penetration of imatinib mesylate (Gleevec): implications for the use of breast cancer resistance protein and P-glycoprotein inhibitors to enable the brain penetration of imatinib in patients.

01-04-2005

Genes & development

Mouse models for human lung cancer.

15-03-2005

Molecular and cellular biology

Uncoupling anaphase-promoting complex/cyclosome activity from spindle assembly checkpoint control by deregulating polo-like kinase 1.

Journal of cell science

Keratinocytes display normal proliferation, survival and differentiation in conditional beta4-integrin knockout mice.

Anti-cancer drugs

Effects of co-medicated drugs on cyclophosphamide bioactivation in human liver microsomes.

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

Compatibility and stability of the novel anti-cancer agent C1311 in infusion devices and its in vitro biocompatibility.

Cancer chemotherapy and pharmacology

Phase I study of an oral formulation of irinotecan administered daily for 14 days every 3 weeks in patients with advanced solid tumours.

British journal of clinical pharmacology

Population pharmacokinetics of orally administered paclitaxel formulated in Cremophor EL.

Clinical cancer research : an official journal of the American Association for Cancer Research

Phase I clinical and pharmacokinetic study of kahalalide F in patients with advanced androgen refractory prostate cancer.