Publications

Pharmacological research

Pharmacokinetics of paclitaxel administered as a 3-hour or 96-hour infusion.

01-07-1999

British journal of cancer

Oral topotecan: bioavailablity and effect of food co-administration.

01-07-1999

BioEssays : news and reviews in molecular, cellular and developmental biology

Integrins: alternative splicing as a mechanism to regulate ligand binding and integrin signaling events.

01-06-1999

Current opinion in genetics & development

The trithorax-group and polycomb-group chromatin modifiers: implications for disease.

01-06-1999

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Phase I and pharmacokinetic study of irinotecan administered as a low-dose, continuous intravenous infusion over 14 days in patients with malignant solid tumors.

01-06-1999

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Phase I and pharmacokinetic study of a daily times 5 short intravenous infusion schedule of 9-aminocamptothecin in a colloidal dispersion formulation in patients with advanced solid tumors.

01-06-1999

Cancer research

Alkyl-lysophospholipids activate the SAPK/JNK pathway and enhance radiation-induced apoptosis.

15-05-1999

The Journal of biological chemistry

Common regulation of apoptosis signaling induced by CD95 and the DNA-damaging stimuli etoposide and gamma-radiation downstream from caspase-8 activation.

14-05-1999

Cancer chemotherapy and pharmacology

Paclitaxel in the treatment of human immunodeficiency virus 1-associated Kaposi's sarcoma--drug-drug interactions with protease inhibitors and a nonnucleoside reverse transcriptase inhibitor: a case report study.

13-05-1999

Cancer

The development of a prognostic score for patients with parotid carcinoma.

01-05-1999

British journal of pharmacology

Role of blood-brain barrier P-glycoprotein in limiting brain accumulation and sedative side-effects of asimadoline, a peripherally acting analgaesic drug.

01-05-1999

Trends in genetics : TIG

Mouse models for cancer at center stage. AACR special meeting: Cancer Biology and the Mutant Mouse: New Methods, New Models, New Insights, Keystone Colorado, USA, 31 January-5 February 1999.

01-05-1999

Journal of chromatography. B, Biomedical sciences and applications

Quantification of topotecan and its metabolite N-desmethyltopotecan in human plasma, urine and faeces by high-performance liquid chromatographic methods.

30-04-1999

Advanced drug delivery reviews

P-Glycoprotein, a gatekeeper in the blood-brain barrier.

05-04-1999

European journal of immunology

Systemic T cell expansion during localized viral infection.

01-04-1999

Immunology today

Turning the immune system on.

01-04-1999

Cancer treatment reviews

Clinical pharmacology of anticancer agents in relation to formulations and administration routes.

01-04-1999

Cancer research

Identification and characterization of collaborating oncogenes in compound mutant mice.

01-04-1999

The Journal of clinical investigation

Ordering of ceramide formation, caspase activation, and mitochondrial changes during CD95- and DNA damage-induced apoptosis.

01-04-1999

Seminars in cell & developmental biology

Cellular memory of transcriptional states by Polycomb-group proteins.

01-04-1999

The Journal of pharmacology and experimental therapeutics

Comparative pharmacokinetics of vinblastine after a 96-hour continuous infusion in wild-type mice and mice lacking mdr1a P-glycoprotein.

01-04-1999

Cancer chemotherapy and pharmacology

A single 24-hour plasma sample does not predict the carboplatin AUC from carboplatin-paclitaxel combinations or from a high-dose carboplatin-thiotepa-cyclophosphamide regimen.

01-04-1999

Biochimica et biophysica acta

CSH Meeting on Cancer Genetics 1998.

25-03-1999

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Phase I and pharmacologic study of the combination of paclitaxel, cisplatin, and topotecan administered intravenously every 21 days as first-line therapy in patients with advanced ovarian cancer.

01-03-1999

British journal of cancer

Phase II trial of topically applied miltefosine solution in patients with skin-metastasized breast cancer.

01-03-1999

Matrix biology : journal of the International Society for Matrix Biology

Biology and function of hemidesmosomes.

01-02-1999

Cancer

Cognitive deficits after postoperative adjuvant chemotherapy for breast carcinoma.

01-02-1999

British journal of cancer

Potentiation of anti-cancer drug activity at low intratumoral pH induced by the mitochondrial inhibitor m-iodobenzylguanidine (MIBG) and its analogue benzylguanidine (BG).

01-02-1999

Therapeutic drug monitoring

Sampling technique from central venous catheters proves critical for pharmacokinetic studies.

01-02-1999

British journal of cancer

Bioavailability and toxicity after oral administration of m-iodobenzylguanidine (MIBG).

01-02-1999

Oncogene

Rapid dephosphorylation of p107 following UV irradiation.

21-01-1999

Current biology : CB

Multivesicular body morphogenesis requires phosphatidyl-inositol 3-kinase activity.

14-01-1999

Nature

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus.

14-01-1999

Oncogene

Functional interaction between a novel protein phosphatase 2A regulatory subunit, PR59, and the retinoblastoma-related p107 protein.

14-01-1999

Anti-cancer drugs

Topoisomerase I/II inhibitor intoplicine administered as a 24 h infusion: phase I and pharmacologic study.

01-01-1999

British journal of cancer

Increased accumulation of doxorubicin and doxorubicinol in cardiac tissue of mice lacking mdr1a P-glycoprotein.

01-01-1999

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Towards prediction and modulation of treatment response.

01-01-1999

Acta oncologica (Stockholm, Sweden)

Radiation-induced apoptosis--the ceramide-SAPK signaling pathway and clinical aspects.

22-12-1998

Investigational new drugs

Pharmaceutical development of a parenteral lyophilized formulation of the investigational antitumor neuropeptide antagonist [Arg6, D-Trp7,9, MePhe8]-Substance P [6-11].

16-12-1998

The EMBO journal

A link between cell cycle and cell death: Bax and Bcl-2 modulate Cdk2 activation during thymocyte apoptosis.

15-12-1998

Seminars in immunology

Tumor necrosis factor receptor family members in the immune system.

01-12-1998

Journal of chromatography. B, Biomedical sciences and applications

High-performance liquid chromatographic bio-analysis of PSC 833 in human and murine plasma.

20-11-1998

Genes & development

Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1.

15-11-1998

Journal of mass spectrometry : JMS

Quantitative determination of Ecteinascidin 743 in human plasma by miniaturized high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.

01-11-1998

Cancer research

High frequency of interactions between lung cancer susceptibility genes in the mouse: mapping of Sluc5 to Sluc14.

01-11-1998

Radiation research

Increased expression of glomerular von Willebrand factor after irradiation of the mouse kidney.

01-11-1998

Journal of clinical epidemiology

Translation, validation, and norming of the Dutch language version of the SF-36 Health Survey in community and chronic disease populations.

01-11-1998

Human mutation

ATM germline mutations in classical ataxia-telangiectasia patients in the Dutch population.

29-10-1998

The Journal of cell biology

Cre-loxP-mediated inactivation of the alpha6A integrin splice variant in vivo: evidence for a specific functional role of alpha6A in lymphocyte migration but not in heart development.

05-10-1998

Molecular and cellular biology

Biosynthesis and function of the modified DNA base beta-D-glucosyl-hydroxymethyluracil in Trypanosoma brucei.

01-10-1998