Publications

Current opinion in immunology

Preclinical development of T cell receptor gene therapy.

Drug metabolism and disposition: the biological fate of chemicals

Organic anion-transporting polypeptide 1B1 mediates transport of Gimatecan and BNP1350 and can be inhibited by several classic ATP-binding cassette (ABC) B1 and/or ABCG2 inhibitors.

Investigational new drugs

Application of population pharmacokinetic modeling in early clinical development of the anticancer agent E7820.

International journal of radiation oncology, biology, physics

Health-related quality of life in cervical cancer survivors: a population-based survey.

International journal of radiation oncology, biology, physics

Setup uncertainties of anatomical sub-regions in head-and-neck cancer patients after offline CBCT guidance.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

The impact of postmastectomy radiotherapy on local control in patients with invasive lobular breast cancer.

Current opinion in immunology

Adoptive T cell therapy of cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research

Brain accumulation of dasatinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by elacridar treatment.

Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society

Expression of insulin-like growth factor system components in colorectal tissue and its relation with serum IGF levels.

Acta oncologica (Stockholm, Sweden)

Persistent neuropathy after treatment with cisplatin and oxaliplatin.

25-03-2009

British journal of cancer

Inter-observer variability in mammography screening and effect of type and number of readers on screening outcome.

24-03-2009

Clinical cancer research : an official journal of the American Association for Cancer Research

Combining radiotherapy with APO010 in cancer treatment.

15-03-2009

PloS one

A large scale shRNA barcode screen identifies the circadian clock component ARNTL as putative regulator of the p53 tumor suppressor pathway.

12-03-2009

Philosophical transactions of the Royal Society of London. Series B, Biological sciences

Somatic hypermutation of immunoglobulin genes: lessons from proliferating cell nuclear antigenK164R mutant mice.

12-03-2009

Methods in molecular biology (Clifton, N.J.)

Generation of double-knockout embryonic stem cells.

07-03-2009

Methods in molecular biology (Clifton, N.J.)

Gene modification in embryonic stem cells by single-stranded DNA oligonucleotides.

07-03-2009

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

PXR-mediated induction of human CYP3A4 and mouse Cyp3a11 by the glucocorticoid budesonide.

02-03-2009

J Pathol.: The journal of pathology

Conditional Pten knock-out mice: a model for metastatic phaeochromocytoma

European journal of cancer (Oxford, England : 1990)

Delayed diagnosis of breast cancer in women recalled for suspicious screening mammography.

Journal of clinical pathology

Opt-out plus, the patients' choice: preferences of cancer patients concerning information and consent regimen for future research with biological samples archived in the context of treatment.

European journal of cancer (Oxford, England : 1990)

Improving the efficiency of a chemotherapy day unit: applying a business approach to oncology.

International journal of clinical pharmacology and therapeutics

Bioequivalence study of a new oral topotecan formulation, relative to the current topotecan formulation, in patients with advanced solid tumors.

Proteins

Insights into the DNA cleavage mechanism of human LINE-1 retrotransposon endonuclease.

Rapid communications in mass spectrometry : RCM

Validated assay for the simultaneous quantification of total vincristine and actinomycin-D concentrations in human EDTA plasma and of vincristine concentrations in human plasma ultrafiltrate by high-performance liquid chromatography coupled with tandem mass spectrometry.

European journal of nuclear medicine and molecular imaging

Noninvasive functional imaging of P-glycoprotein-mediated doxorubicin resistance in a mouse model of hereditary breast cancer to predict response, and assign P-gp inhibitor sensitivity.

Journal of pharmaceutical and biomedical analysis

Development and validation of an anion-exchange LC-UV method for the quantification and purity determination of the DNA plasmid pDERMATT.

20-02-2009

Hereditary cancer in clinical practice

The contribution of CHEK2 to the TP53-negative Li-Fraumeni phenotype.

17-02-2009

Structure (London, England : 1993)

"Conditional Restraints": Restraining the Free Atoms in ARP/wARP.

13-02-2009

Molecular cell

Reconstitution of yeast silent chromatin: multiple contact sites and O-AADPR binding load SIR complexes onto nucleosomes in vitro.

13-02-2009

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

Estradiol and testosterone levels are lower after oophorectomy than after natural menopause.

06-02-2009

Chromosoma

Chromatin domains in higher eukaryotes: insights from genome-wide mapping studies.

Drug metabolism and disposition: the biological fate of chemicals

Methotrexate pharmacokinetics in transgenic mice with liver-specific expression of human organic anion-transporting polypeptide 1B1 (SLCO1B1).

Cancer chemotherapy and pharmacology

Carbamazepine induces bioactivation of cyclophosphamide and thiotepa.

Journal of pharmacokinetics and pharmacodynamics

Covariate-based dose individualization of the cytotoxic drug indisulam to reduce the risk of severe myelosuppression.

Clinical pharmacology and therapeutics

Novel clinical trial designs for innovative therapies.

Cancer biotherapy & radiopharmaceuticals

A simple and safe method for 131I radiolabeling of rituximab for myeloablative high-dose radioimmunotherapy.

Investigational new drugs

The effect of P-gp (Mdr1a/1b), BCRP (Bcrp1) and P-gp/BCRP inhibitors on the in vivo absorption, distribution, metabolism and excretion of imatinib.

Therapeutic drug monitoring

Pharmacokinetics of cyclophosphamide and thiotepa in a conventional fractionated high-dose regimen compared with a novel simplified unfractionated regimen.

Cancer treatment reviews

An overview of the relations between polymorphisms in drug metabolising enzymes and drug transporters and survival after cancer drug treatment.

Nature reviews. Cancer

Senescence-messaging secretome: SMS-ing cellular stress.

The Laryngoscope

Radiotherapy in laryngeal carcinoma: can a panel of 13 markers predict response?

Advanced drug delivery reviews

Physiological and pharmacological roles of ABCG2 (BCRP): recent findings in Abcg2 knockout mice.

31-01-2009

BMC bioinformatics

Analysis of mass spectrometry data using sub-spectra.

30-01-2009

Epigenetics & chromatin

High-resolution mapping of heterochromatin redistribution in a Drosophila position-effect variegation model.

29-01-2009

Journal of cell science

Integrin alpha3beta1 inhibits directional migration and wound re-epithelialization in the skin.

15-01-2009

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Intestinal cytochrome P450 3A plays an important role in the regulation of detoxifying systems in the liver.

Cancer chemotherapy and pharmacology

Altered cyclophosphamide and thiotepa pharmacokinetics in a patient with moderate renal insufficiency.

Drug metabolism and disposition: the biological fate of chemicals

Transport of diclofenac by breast cancer resistance protein (ABCG2) and stimulation of multidrug resistance protein 2 (ABCC2)-mediated drug transport by diclofenac and benzbromarone.

British journal of clinical pharmacology

Polymorphisms of drug-metabolizing enzymes (GST, CYP2B6 and CYP3A) affect the pharmacokinetics of thiotepa and tepa.