Publications

Proteins

Insights into the DNA cleavage mechanism of human LINE-1 retrotransposon endonuclease.

Rapid communications in mass spectrometry : RCM

Validated assay for the simultaneous quantification of total vincristine and actinomycin-D concentrations in human EDTA plasma and of vincristine concentrations in human plasma ultrafiltrate by high-performance liquid chromatography coupled with tandem mass spectrometry.

European journal of nuclear medicine and molecular imaging

Noninvasive functional imaging of P-glycoprotein-mediated doxorubicin resistance in a mouse model of hereditary breast cancer to predict response, and assign P-gp inhibitor sensitivity.

Journal of pharmaceutical and biomedical analysis

Development and validation of an anion-exchange LC-UV method for the quantification and purity determination of the DNA plasmid pDERMATT.

20-02-2009

Hereditary cancer in clinical practice

The contribution of CHEK2 to the TP53-negative Li-Fraumeni phenotype.

17-02-2009

Structure (London, England : 1993)

"Conditional Restraints": Restraining the Free Atoms in ARP/wARP.

13-02-2009

Molecular cell

Reconstitution of yeast silent chromatin: multiple contact sites and O-AADPR binding load SIR complexes onto nucleosomes in vitro.

13-02-2009

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

Estradiol and testosterone levels are lower after oophorectomy than after natural menopause.

06-02-2009

Chromosoma

Chromatin domains in higher eukaryotes: insights from genome-wide mapping studies.

Drug metabolism and disposition: the biological fate of chemicals

Methotrexate pharmacokinetics in transgenic mice with liver-specific expression of human organic anion-transporting polypeptide 1B1 (SLCO1B1).

Cancer chemotherapy and pharmacology

Carbamazepine induces bioactivation of cyclophosphamide and thiotepa.

Journal of pharmacokinetics and pharmacodynamics

Covariate-based dose individualization of the cytotoxic drug indisulam to reduce the risk of severe myelosuppression.

Clinical pharmacology and therapeutics

Novel clinical trial designs for innovative therapies.

Cancer biotherapy & radiopharmaceuticals

A simple and safe method for 131I radiolabeling of rituximab for myeloablative high-dose radioimmunotherapy.

Investigational new drugs

The effect of P-gp (Mdr1a/1b), BCRP (Bcrp1) and P-gp/BCRP inhibitors on the in vivo absorption, distribution, metabolism and excretion of imatinib.

Therapeutic drug monitoring

Pharmacokinetics of cyclophosphamide and thiotepa in a conventional fractionated high-dose regimen compared with a novel simplified unfractionated regimen.

Cancer treatment reviews

An overview of the relations between polymorphisms in drug metabolising enzymes and drug transporters and survival after cancer drug treatment.

Nature reviews. Cancer

Senescence-messaging secretome: SMS-ing cellular stress.

The Laryngoscope

Radiotherapy in laryngeal carcinoma: can a panel of 13 markers predict response?

Advanced drug delivery reviews

Physiological and pharmacological roles of ABCG2 (BCRP): recent findings in Abcg2 knockout mice.

31-01-2009

BMC bioinformatics

Analysis of mass spectrometry data using sub-spectra.

30-01-2009

Epigenetics & chromatin

High-resolution mapping of heterochromatin redistribution in a Drosophila position-effect variegation model.

29-01-2009

Journal of cell science

Integrin alpha3beta1 inhibits directional migration and wound re-epithelialization in the skin.

15-01-2009

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Intestinal cytochrome P450 3A plays an important role in the regulation of detoxifying systems in the liver.

Cancer chemotherapy and pharmacology

Altered cyclophosphamide and thiotepa pharmacokinetics in a patient with moderate renal insufficiency.

Drug metabolism and disposition: the biological fate of chemicals

Transport of diclofenac by breast cancer resistance protein (ABCG2) and stimulation of multidrug resistance protein 2 (ABCC2)-mediated drug transport by diclofenac and benzbromarone.

British journal of clinical pharmacology

Polymorphisms of drug-metabolizing enzymes (GST, CYP2B6 and CYP3A) affect the pharmacokinetics of thiotepa and tepa.

Current clinical pharmacology

Evaluation of human plasma protein binding of trabectedin (Yondelis, ET-743).

Biochimica et biophysica acta

Protein phosphatase 2A regulatory subunits and cancer.

European journal of cancer (Oxford, England : 1990)

The frequency, magnitude and timing of post-diagnosis body weight gain in Dutch breast cancer survivors.

The international journal of biochemistry & cell biology

Molecular basis of the anti-cancer effects of histone deacetylase inhibitors.

Breast cancer research and treatment

Comparison of gene expression profiles predicting progression in breast cancer patients treated with tamoxifen.

International journal of radiation oncology, biology, physics

Bowel, urinary, and sexual problems among long-term prostate cancer survivors: a population-based study.

International journal of technology assessment in health care

Constructive Technology Assessment (CTA) as a tool in coverage with evidence development: the case of the 70-gene prognosis signature for breast cancer diagnostics.

Breast cancer research and treatment

Stage migration due to introduction of the sentinel node procedure: a population-based study.

BMC cancer

Haptoglobin phenotype is not a predictor of recurrence free survival in high-risk primary breast cancer patients.

24-12-2008

Breast cancer research : BCR

EZH2 and BMI1 inversely correlate with prognosis and TP53 mutation in breast cancer.

23-12-2008

Immunity

Expression of costimulatory ligand CD70 on steady-state dendritic cells breaks CD8+ T cell tolerance and permits effective immunity.

19-12-2008

Chembiochem : a European journal of chemical biology

Chemical biology approaches to probe the proteome.

15-12-2008

Clinical cancer research : an official journal of the American Association for Cancer Research

Impact of Abcc2 (Mrp2) and Abcc3 (Mrp3) on the in vivo elimination of methotrexate and its main toxic metabolite 7-hydroxymethotrexate.

15-12-2008

Clinical drug investigation

Ciprofloxacin strongly inhibits clozapine metabolism: two case reports.

11-12-2008

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Roles of radiotherapy and chemotherapy in the development of contralateral breast cancer.

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

Propofol extravasation in a breast cancer patient.

BJU international

Does diabetes mellitus as a comorbid condition affect the health-related quality of life in prostate cancer survivors? Results of a population-based observational study.

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation

Using patient-reported outcomes in clinical practice: proceedings of an International Society of Quality of Life Research conference.

Journal of computational biology : a journal of computational molecular cell biology

Biclustering sparse binary genomic data.