Publications

Genes & development

Distinct HP1 and Su(var)3-9 complexes bind to sets of developmentally coexpressed genes depending on chromosomal location.

15-11-2003

The Journal of experimental medicine

CD27 promotes survival of activated T cells and complements CD28 in generation and establishment of the effector T cell pool.

03-11-2003

British journal of cancer

P-glycoprotein and Mrp1 collectively protect the bone marrow from vincristine-induced toxicity in vivo.

03-11-2003

Cancer research

The generation of a conditional reporter that enables bioluminescence imaging of Cre/loxP-dependent tumorigenesis in mice.

01-11-2003

Molecular and cellular biology

Deficiency in the organic cation transporters 1 and 2 (Oct1/Oct2 [Slc22a1/Slc22a2]) in mice abolishes renal secretion of organic cations.

01-11-2003

The Journal of biological chemistry

Calcium signaling regulates translocation and activation of Rac.

10-10-2003

Cancer research

The breast cancer resistance protein (Bcrp1/Abcg2) restricts exposure to the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.

01-10-2003

Nature reviews. Cancer

New tools for functional mammalian cancer genetics.

01-10-2003

Drug development and industrial pharmacy

Pharmaceutical development of a parenteral lyophilized formulation of the investigational polymer-conjugated platinum anticancer agent AP 5280.

01-10-2003

Cancer cell

The tumor-suppressive functions of the human INK4A locus.

01-10-2003

Molecular biology of the cell

Specificity of binding of the plectin actin-binding domain to beta4 integrin.

01-10-2003

Cell cycle (Georgetown, Tex.)

The survivin/Aurora B complex: its role in coordinating tension and attachment.

25-09-2003

The Biochemical journal

Different modes of internalization of apoptotic alkyl-lysophospholipid and cell-rescuing lysophosphatidylcholine.

15-09-2003

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Long-term cause-specific mortality of patients treated for Hodgkin's disease.

15-09-2003

Clinical cancer research : an official journal of the American Association for Cancer Research

Randomized phase I clinical and pharmacologic study of weekly versus twice-weekly dose-intensive cisplatin and gemcitabine in patients with advanced non-small cell lung cancer.

01-09-2003

European journal of cancer (Oxford, England : 1990)

Improved survival of patients with rectal cancer since 1980: a population-based study.

01-09-2003

Cancer cell

Induction of small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional mouse model.

01-09-2003

Human reproduction (Oxford, England)

Risk of benign gynaecological diseases and hormonal disorders according to responsiveness to ovarian stimulation in IVF: a follow-up study of 8714 women.

01-09-2003

Nucleic acids research

Structures of Escherichia coli DNA mismatch repair enzyme MutS in complex with different mismatches: a common recognition mode for diverse substrates.

15-08-2003

Nature

Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB.

14-08-2003

Acta oncologica (Stockholm, Sweden)

Psychosocial issues in cancer genetics--current status and future directions.

06-08-2003

Seminars in cancer biology

Ras interference as cancer therapy.

01-08-2003

BioTechniques

Epigenomic profiling using microarrays.

01-08-2003

Anti-cancer drugs

Yondelis (trabectedin, ET-743): the development of an anticancer agent of marine origin.

01-08-2003

PDA journal of pharmaceutical science and technology

Pharmaceutical quality control of the investigational polymer-conjugated platinum anticancer agent AP 5280.

25-07-2003

The New England journal of medicine

High-dose chemotherapy with hematopoietic stem-cell rescue for high-risk breast cancer.

03-07-2003

Journal of the National Cancer Institute

Roles of radiation dose, chemotherapy, and hormonal factors in breast cancer following Hodgkin's disease.

02-07-2003

Journal of the National Cancer Institute

Potential for bias in studies on efficacy of prophylactic surgery for BRCA1 and BRCA2 mutation.

02-07-2003

The Journal of pathology

Integrins in regulation of tissue development and function.

01-07-2003

Laboratory animals

Cannulation of the jugular vein in mice: a method for serial withdrawal of blood samples.

01-07-2003

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

High response rates and lasting remissions after low-dose involved field radiotherapy in indolent lymphomas.

01-07-2003

Human reproduction (Oxford, England)

Increased risk of early menopausal transition and natural menopause after poor response at first IVF treatment.

01-07-2003

Clinical cancer research : an official journal of the American Association for Cancer Research

Increased penetration of paclitaxel into the brain by inhibition of P-Glycoprotein.

01-07-2003

Anti-cancer drugs

In vitro pharmacokinetic study of the novel anticancer agent E7070: red blood cell and plasma protein binding in human blood.

01-07-2003

The Netherlands journal of medicine

Compassionate use programme of irinotecan in colorectal cancer patients in The Netherlands.

01-07-2003

The Journal of biological chemistry

Evidence for two interacting ligand binding sites in human multidrug resistance protein 2 (ATP binding cassette C2).

27-06-2003

The EMBO journal

Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension.

16-06-2003

Nederlands tijdschrift voor geneeskunde

[Trends in the incidence and prevalence of cancer and in the survival of patients in southeastern Netherlands, 1970-1999].

07-06-2003

Medical physics

Focal spot motion of linear accelerators and its effect on portal image analysis.

01-06-2003

Therapeutic drug monitoring

Sorption of thiotepa to polyurethane catheter causes falsely elevated plasma levels.

01-06-2003

Journal of leukocyte biology

Decisions on life and death: FOXO Forkhead transcription factors are in command when PKB/Akt is off duty.

01-06-2003

Oncogene

LOH of PTPRJ occurs early in colorectal cancer and is associated with chromosomal loss of 18q12-21.

29-05-2003

The Journal of biological chemistry

Characterization of the MRP4- and MRP5-mediated transport of cyclic nucleotides from intact cells.

16-05-2003

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

Serum soluble CD27, but not thymidine kinase, is an independent prognostic factor for outcome in indolent non-Hodgkin's lymphoma.

14-05-2003

Human mutation

IVS10-6T>G, an ancient ATM germline mutation linked with breast cancer.

01-05-2003

Molecular and cellular biology

Constitutive E2F1 overexpression delays endochondral bone formation by inhibiting chondrocyte differentiation.

01-05-2003

Journal of mass spectrometry : JMS

Quantitative analysis of ES-285, an investigational marine anticancer drug, in human, mouse, rat, and dog plasma using coupled liquid chromatography and tandem mass spectrometry.

01-05-2003

Investigational new drugs

Pharmacokinetic-pharmacodynamic guided trial design in oncology.

01-05-2003

Annual review of biophysics and biomolecular structure

Acetylcholine binding protein (AChBP): a secreted glial protein that provides a high-resolution model for the extracellular domain of pentameric ligand-gated ion channels.

16-04-2003

Population health metrics

Estimating the prevalence of breast cancer using a disease model: data problems and trends.

14-04-2003