Publications

Current opinion in immunology

Preclinical development of T cell receptor gene therapy.

Drug metabolism and disposition: the biological fate of chemicals

Organic anion-transporting polypeptide 1B1 mediates transport of Gimatecan and BNP1350 and can be inhibited by several classic ATP-binding cassette (ABC) B1 and/or ABCG2 inhibitors.

Investigational new drugs

Application of population pharmacokinetic modeling in early clinical development of the anticancer agent E7820.

International journal of radiation oncology, biology, physics

Health-related quality of life in cervical cancer survivors: a population-based survey.

International journal of radiation oncology, biology, physics

Setup uncertainties of anatomical sub-regions in head-and-neck cancer patients after offline CBCT guidance.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

The impact of postmastectomy radiotherapy on local control in patients with invasive lobular breast cancer.

Current opinion in immunology

Adoptive T cell therapy of cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research

Brain accumulation of dasatinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by elacridar treatment.

Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society

Expression of insulin-like growth factor system components in colorectal tissue and its relation with serum IGF levels.

Acta oncologica (Stockholm, Sweden)

Persistent neuropathy after treatment with cisplatin and oxaliplatin.

25-03-2009

British journal of cancer

Inter-observer variability in mammography screening and effect of type and number of readers on screening outcome.

24-03-2009

Clinical cancer research : an official journal of the American Association for Cancer Research

Combining radiotherapy with APO010 in cancer treatment.

15-03-2009

PloS one

A large scale shRNA barcode screen identifies the circadian clock component ARNTL as putative regulator of the p53 tumor suppressor pathway.

12-03-2009

Philosophical transactions of the Royal Society of London. Series B, Biological sciences

Somatic hypermutation of immunoglobulin genes: lessons from proliferating cell nuclear antigenK164R mutant mice.

12-03-2009

Methods in molecular biology (Clifton, N.J.)

Generation of double-knockout embryonic stem cells.

07-03-2009

Methods in molecular biology (Clifton, N.J.)

Gene modification in embryonic stem cells by single-stranded DNA oligonucleotides.

07-03-2009

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

PXR-mediated induction of human CYP3A4 and mouse Cyp3a11 by the glucocorticoid budesonide.

02-03-2009

J Pathol.: The journal of pathology

Conditional Pten knock-out mice: a model for metastatic phaeochromocytoma

European journal of cancer (Oxford, England : 1990)

Delayed diagnosis of breast cancer in women recalled for suspicious screening mammography.

Journal of clinical pathology

Opt-out plus, the patients' choice: preferences of cancer patients concerning information and consent regimen for future research with biological samples archived in the context of treatment.

European journal of cancer (Oxford, England : 1990)

Improving the efficiency of a chemotherapy day unit: applying a business approach to oncology.

International journal of clinical pharmacology and therapeutics

Bioequivalence study of a new oral topotecan formulation, relative to the current topotecan formulation, in patients with advanced solid tumors.

Proteins

Insights into the DNA cleavage mechanism of human LINE-1 retrotransposon endonuclease.

Rapid communications in mass spectrometry : RCM

Validated assay for the simultaneous quantification of total vincristine and actinomycin-D concentrations in human EDTA plasma and of vincristine concentrations in human plasma ultrafiltrate by high-performance liquid chromatography coupled with tandem mass spectrometry.

European journal of nuclear medicine and molecular imaging

Noninvasive functional imaging of P-glycoprotein-mediated doxorubicin resistance in a mouse model of hereditary breast cancer to predict response, and assign P-gp inhibitor sensitivity.

Journal of pharmaceutical and biomedical analysis

Development and validation of an anion-exchange LC-UV method for the quantification and purity determination of the DNA plasmid pDERMATT.

20-02-2009

Hereditary cancer in clinical practice

The contribution of CHEK2 to the TP53-negative Li-Fraumeni phenotype.

17-02-2009

Structure (London, England : 1993)

"Conditional Restraints": Restraining the Free Atoms in ARP/wARP.

13-02-2009

Molecular cell

Reconstitution of yeast silent chromatin: multiple contact sites and O-AADPR binding load SIR complexes onto nucleosomes in vitro.

13-02-2009

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

Estradiol and testosterone levels are lower after oophorectomy than after natural menopause.

06-02-2009

Chromosoma

Chromatin domains in higher eukaryotes: insights from genome-wide mapping studies.

Drug metabolism and disposition: the biological fate of chemicals

Methotrexate pharmacokinetics in transgenic mice with liver-specific expression of human organic anion-transporting polypeptide 1B1 (SLCO1B1).

Cancer chemotherapy and pharmacology

Carbamazepine induces bioactivation of cyclophosphamide and thiotepa.

Journal of pharmacokinetics and pharmacodynamics

Covariate-based dose individualization of the cytotoxic drug indisulam to reduce the risk of severe myelosuppression.

Clinical pharmacology and therapeutics

Novel clinical trial designs for innovative therapies.

Cancer biotherapy & radiopharmaceuticals

A simple and safe method for 131I radiolabeling of rituximab for myeloablative high-dose radioimmunotherapy.

Investigational new drugs

The effect of P-gp (Mdr1a/1b), BCRP (Bcrp1) and P-gp/BCRP inhibitors on the in vivo absorption, distribution, metabolism and excretion of imatinib.

Therapeutic drug monitoring

Pharmacokinetics of cyclophosphamide and thiotepa in a conventional fractionated high-dose regimen compared with a novel simplified unfractionated regimen.

Cancer treatment reviews

An overview of the relations between polymorphisms in drug metabolising enzymes and drug transporters and survival after cancer drug treatment.