Publications

Cancer treatment reviews

Modulation of the blood-brain barrier in oncology: therapeutic opportunities for the treatment of brain tumours?

01-08-2004

Investigational new drugs

Efficacy of novel P-glycoprotein inhibitors to increase the oral uptake of paclitaxel in mice.

01-08-2004

Cell death and differentiation

Mechanism of action of Drosophila Reaper in mammalian cells: Reaper globally inhibits protein synthesis and induces apoptosis independent of mitochondrial permeability.

01-08-2004

The Lancet. Oncology

Drug interactions in oncology.

01-08-2004

British journal of cancer

Trends in the usage of adjuvant systemic therapy for breast cancer in the Netherlands and its effect on mortality.

19-07-2004

Nederlands tijdschrift voor geneeskunde

[Methods and results of in-vitro fertilisation in the Netherlands in the years 1983-1994].

17-07-2004

Clinical cancer research : an official journal of the American Association for Cancer Research

On the role of melanoma-specific CD8+ T-cell immunity in disease progression of advanced-stage melanoma patients.

15-07-2004

International journal of pharmaceutics

2-Hydroxypropyl-beta-cyclodextrin extracts 2-phenylphenol from silicone tubing.

08-07-2004

Nederlands tijdschrift voor geneeskunde

[Young adults with Ewing's sarcoma].

03-07-2004

The Journal of biological chemistry

Requirement for aspartate-cleaved bid in apoptosis signaling by DNA-damaging anti-cancer regimens.

02-07-2004

Biomedical chromatography : BMC

Switching from an analogous to a stable isotopically labeled internal standard for the LC-MS/MS quantitation of the novel anticancer drug Kahalalide F significantly improves assay performance.

01-07-2004

Clinical cancer research : an official journal of the American Association for Cancer Research

Predicting early failure after adjuvant chemotherapy in high-risk breast cancer patients with extensive lymph node involvement.

01-07-2004

European journal of cancer (Oxford, England : 1990)

Staging in patients with locoregionally recurrent breast cancer: current practice and prospects for positron emission tomography.

01-07-2004

International journal of radiation oncology, biology, physics

In vivo imaging of radiation-induced apoptosis in follicular lymphoma patients.

01-07-2004

Biomedical chromatography : BMC

A more sensitive MS detector does not obviously lead to a more sensitive assay: experiences with ES-285.

01-07-2004

Cancer chemotherapy and pharmacology

Cytotoxicity of the organic ruthenium anticancer drug Nami-A is correlated with DNA binding in four different human tumor cell lines.

01-07-2004

Molecular and cellular biology

Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors.

01-07-2004

Rapid communications in mass spectrometry : RCM

Quantitative analysis of D-24851, a novel anticancer agent, in human plasma and urine by liquid chromatography coupled with tandem mass spectrometry.

25-06-2004

The Journal of biological chemistry

Characterization and functional analysis of the murine Frat2 gene.

25-06-2004

Oncogene

An in vivo functional genetic screen reveals a role for the TRK-T3 oncogene in tumor progression.

24-06-2004

The Biochemical journal

Optimizing RNA interference for application in mammalian cells.

15-06-2004

Journal of immunology (Baltimore, Md. : 1950)

CD27 is acquired by primed B cells at the centroblast stage and promotes germinal center formation.

15-06-2004

British journal of cancer

Phase I and pharmacokinetic study of the combination of topotecan and ifosfamide administered intravenously every 3 weeks.

14-06-2004

Journal of the American Geriatrics Society

Antihypertensive medications and differences in muscle mass in older persons: the Health, Aging and Body Composition Study.

01-06-2004

Structure (London, England : 1993)

Crystal structure of the targeting endonuclease of the human LINE-1 retrotransposon.

01-06-2004

Genes & development

The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote.

01-06-2004

Current opinion in cell biology

Polycomb complexes and silencing mechanisms.

01-06-2004

Cancer cell

Tamoxifen resistance by a conformational arrest of the estrogen receptor alpha after PKA activation in breast cancer.

01-06-2004

Clinical cancer research : an official journal of the American Association for Cancer Research

A Phase I and pharmacological study with imidazolium-trans-DMSO-imidazole-tetrachlororuthenate, a novel ruthenium anticancer agent.

01-06-2004

Science (New York, N.Y.)

Antigen bias in T cell cross-priming.

28-05-2004

Clinical cancer research : an official journal of the American Association for Cancer Research

A Phase I and pharmacological study of the platinum polymer AP5280 given as an intravenous infusion once every 3 weeks in patients with solid tumors.

15-05-2004

European journal of cancer (Oxford, England : 1990)

Improved penetration of docetaxel into the brain by co-administration of inhibitors of P-glycoprotein.

01-05-2004

Cell cycle (Georgetown, Tex.)

Unraveling human tumor suppressor pathways: a tale of the INK4A locus.

01-05-2004

British journal of cancer

Clinical outcome of prophylactic oophorectomy in BRCA1/BRCA2 mutation carriers and events during follow-up.

19-04-2004

The New England journal of medicine

Good news for gene therapy.

15-04-2004

Clinical cancer research : an official journal of the American Association for Cancer Research

Bayesian pharmacokinetically guided dosing of paclitaxel in patients with non-small cell lung cancer.

01-04-2004

Breast cancer research and treatment

Insulin-like growth factor (IGF)-system mRNA quantities in normal and tumor breast tissue of women with sporadic and familial breast cancer risk.

01-04-2004

Investigational new drugs

Pharmacokinetic drug-drug interaction of the novel anticancer agent E7070 and acenocoumarol.

01-04-2004

Journal of pharmacokinetics and pharmacodynamics

Integrated Population Pharmacokinetic Model of both cyclophosphamide and thiotepa suggesting a mutual drug-drug interaction.

01-04-2004

Journal of mass spectrometry : JMS

Simple and sensitive liquid chromatographic quantitative analysis of the novel marine anticancer drug Yondelis (ET-743, trabectedin) in human plasma using column switching and tandem mass spectrometric detection.

01-04-2004

Human reproduction (Oxford, England)

The number of retrieved oocytes does not decrease during consecutive gonadotrophin-stimulated IVF cycles.

01-04-2004

Biophysical journal

Correcting confocal acquisition to optimize imaging of fluorescence resonance energy transfer by sensitized emission.

01-04-2004

Neuron

Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures.

25-03-2004

Nature

A large-scale RNAi screen in human cells identifies new components of the p53 pathway.

25-03-2004

Nederlands tijdschrift voor geneeskunde

[Genetic research with stored human tissue: a coding procedure with optimal use of information and protection of privacy].

20-03-2004

Cancer research

Human telomerase reverse transcriptase-transduced human cytotoxic T cells suppress the growth of human melanoma in immunodeficient mice.

15-03-2004

The Journal of biological chemistry

High incidence of thymic epithelial tumors in E2F2 transgenic mice.

12-03-2004

Journal of mass spectrometry : JMS

Quantitative analysis of the novel anticancer drug ABT-518, a matrix metalloproteinase inhibitor, plus the screening of six metabolites in human plasma using high-performance liquid chromatography coupled with electrospray tandem mass spectrometry.

01-03-2004

Journal of mass spectrometry : JMS

Simultaneous quantification of cyclophosphamide, 4-hydroxycyclophosphamide, N,N',N"-triethylenethiophosphoramide (thiotepa) and N,N',N"-triethylenephosphoramide (tepa) in human plasma by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.

01-03-2004

Molecular biology of the cell

Role of binding of plectin to the integrin beta4 subunit in the assembly of hemidesmosomes.

01-03-2004