Publications

JAMA oncology

Comparison of Immediate vs Deferred Cytoreductive Nephrectomy in Patients With Synchronous Metastatic Renal Cell Carcinoma Receiving Sunitinib: The SURTIME Randomized Clinical Trial.

01-02-2019

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Development and validation of an UPLC-MS/MS method for the therapeutic drug monitoring of oral anti-hormonal drugs in oncology.

01-02-2019

Annals of oncology : official journal of the European Society for Medical Oncology

Position of a panel of international lung cancer experts on the approval decision for use of durvalumab in stage III non-small-cell lung cancer (NSCLC) by the Committee for Medicinal Products for Human Use (CHMP).

01-02-2019

Cancer letters

Metabolic targeting synergizes with MAPK inhibition and delays drug resistance in melanoma.

01-02-2019

Cancer research

Radiosensitivity Is an Acquired Vulnerability of PARPi-Resistant BRCA1-Deficient Tumors.

01-02-2019

Annals of oncology : official journal of the European Society for Medical Oncology

Enhancing antitumor response by combining immune checkpoint inhibitors with chemotherapy in solid tumors.

01-02-2019

International journal of radiation oncology, biology, physics

Tumor Trailing for Liver SBRT on the MR-Linac.

01-02-2019

Nature communications

Shared heritability and functional enrichment across six solid cancers.

25-01-2019

Scientific reports

Effective CRISPR/Cas9-mediated correction of a Fanconi anemia defect by error-prone end joining or templated repair.

25-01-2019

JCI insight

Frequent clonal relations between metastases and non-index prostate cancer lesions.

24-01-2019

Nature communications

Comparative oncogenomics identifies combinations of driver genes and drug targets in BRCA1-mutated breast cancer.

23-01-2019

Briefings in bioinformatics

Principal component analysis of binary genomics data.

18-01-2019

Nature communications

Kinetic analysis of multistep USP7 mechanism shows critical role for target protein in activity.

16-01-2019

Immunity

The First Shall (Be) Last: Understanding Durable T Cell Responses in Immunotherapy.

15-01-2019

Nature communications

BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity.

09-01-2019

Journal of the American Heart Association

Risk and Temporal Changes of Heart Failure Among 5-Year Childhood Cancer Survivors: a DCOG-LATER Study.

08-01-2019

Pharmaceutical research

Impact of Older Age on the Exposure of Paclitaxel: a Population Pharmacokinetic Study.

07-01-2019

Annals of work exposures and health

Diet, Physical Activity, and Daylight Exposure Patterns in Night-Shift Workers and Day Workers.

07-01-2019

American journal of human genetics

Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes.

03-01-2019

International journal of radiation oncology, biology, physics

Subgroup Survival Analysis in Stage I-II NSCLC Patients With a Central Tumor Partly Treated With Risk-Adapted SBRT.

01-01-2019

Human reproduction (Oxford, England)

Iatrogenic endometriosis harbors somatic cancer-driver mutations.

01-01-2019

Annals of oncology : official journal of the European Society for Medical Oncology

Passion for immune checkpoint blockade in triple negative breast cancer: Comment on the IMpassion130 study.

01-01-2019

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Validation and clinical application of an LC-MS/MS method for the quantification of everolimus using volumetric absorptive microsampling.

01-01-2019

Genome medicine

Mechanisms of PARP inhibitor resistance in cancer and insights into the DNA damage response.

28-12-2018

Journal of translational medicine

Towards the use of diffuse reflectance spectroscopy for real-time in vivo detection of breast cancer during surgery.

19-12-2018

Nature communications

The ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivity.

17-12-2018

The Journal of biological chemistry

Profilin binding couples chloride intracellular channel protein CLIC4 to RhoA-mDia2 signaling and filopodium formation.

14-12-2018

Cell

NKG2A, a New Kid on the Immune Checkpoint Block.

13-12-2018

Science (New York, N.Y.)

LZTR1 is a regulator of RAS ubiquitination and signaling.

07-12-2018

EJNMMI research

An analysis of SPECT/CT non-visualization of sentinel lymph nodes in renal tumors.

03-12-2018

The Journal of experimental medicine

Ezh2 inhibition in Kras-driven lung cancer amplifies inflammation and associated vulnerabilities.

03-12-2018

Bioinformatics (Oxford, England)

Modelling signalling networks from perturbation data.

01-12-2018

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Quantitative bioanalytical assay for the tropomyosin receptor kinase inhibitor larotrectinib in mouse plasma and tissue homogenates using liquid chromatography-tandem mass spectrometry.

01-12-2018

Cancer research

Nedd4-Binding Protein 1 and TNFAIP3-Interacting Protein 1 Control MHC-1 Display in Neuroblastoma.

01-12-2018

Journal of pharmaceutical and biomedical analysis

Bioanalytical liquid chromatography-tandem mass spectrometric assay for the quantification of the ALK inhibitors alectinib, brigatinib and lorlatinib in plasma and mouse tissue homogenates.

30-11-2018

Nucleic acids research

Dot1 promotes H2B ubiquitination by a methyltransferase-independent mechanism.

30-11-2018

Genome medicine

A role for the unfolded protein response stress sensor ERN1 in regulating the response to MEK inhibitors in KRAS mutant colon cancers.

27-11-2018

Nature communications

Integrative epigenetic taxonomy of primary prostate cancer.

21-11-2018

Nature biotechnology

T cell receptor fingerprinting enables in-depth characterization of the interactions governing recognition of peptide-MHC complexes.

19-11-2018

Clinical cancer research : an official journal of the American Association for Cancer Research

MELK Inhibition in Diffuse Intrinsic Pontine Glioma.

15-11-2018

International journal of radiation oncology, biology, physics

Quantitative Imaging for Radiation Oncology.

15-11-2018

International journal of radiation oncology, biology, physics

A Self-Sorting Coronal 4D-MRI Method for Daily Image Guidance of Liver Lesions on an MR-LINAC.

15-11-2018

International journal of cancer

Detection of endogenously circulating mesenchymal stem cells in human cancer patients.

15-11-2018

International journal of radiation oncology, biology, physics

Validating a Predictive Atlas of Tumor Shrinkage for Adaptive Radiotherapy of Locally Advanced Lung Cancer.

15-11-2018

Breast cancer research : BCR

Inflammation markers and cognitive performance in breast cancer survivors 20 years after completion of chemotherapy: a cohort study.

15-11-2018

BMC cancer

International phase IV validation study of an EORTC quality of life questionnaire for testicular cancer patients: the EORTC QLQ-TC26.

12-11-2018

The New England journal of medicine

Sunitinib Alone or after Nephrectomy in Renal Cancer.

08-11-2018

Science translational medicine

Enhanced detection of circulating tumor DNA by fragment size analysis.

07-11-2018

BMC cancer

(Cost-)effectiveness of an internet-based physical activity support program (with and without physiotherapy counselling) on physical activity levels of breast and prostate cancer survivors: design of the PABLO trial.

06-11-2018

Molecular pharmaceutics

ABCB1 Attenuates the Brain Penetration of the PARP Inhibitor AZD2461.

05-11-2018