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Metastatic prostate cancer hijacks DNA program for embryonic development
Metastatic prostate cancer cells that spread throughout the
patient's body reactivate a DNA program responsible for fetal
prostatic development, new research shows. Cancer researchers led
by Wilbert Zwart of the Netherlands Cancer Institute and Oncode
Institute, and Matthew Freedman of the Harvard Dana-Farber Cancer
Institute in Boston, demonstrated this process in tissue samples
taken from hundreds of surgically removed prostate tumors.
Pre-existing immune-resistant cancer cells identified in melanoma
Researchers at the Netherlands Cancer Institute and Oncode
Institute have discovered a cluster of tumor cells that are
refractory to immunotherapy and that exists even prior to
treatment. This finding, which was published in the scientific
journal Nature Communications on August 7, may lead to new
therapies that eliminate cancer more effectively.