Publications

Journal of immunology (Baltimore, Md. : 1950)

Low-avidity self-specific T cells display a pronounced expansion defect that can be overcome by altered peptide ligands.

Journal of immunology (Baltimore, Md. : 1950)

Redundancy of direct priming and cross-priming in tumor-specific CD8+ T cell responses.

Acta crystallographica. Section D, Biological crystallography

ARP/wARP and molecular replacement.

Cancer letters

B-myb rescues ras-induced premature senescence, which requires its transactivation domain.

28-09-2001

Investigational new drugs

Compatibility and stability of the investigational polypeptide marine anticancer agent kahalalide F in infusion devices.

20-09-2001

Genes & development

Bidirectional action of the Igf2r imprint control element on upstream and downstream imprinted genes.

15-09-2001

Nature

Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice.

06-09-2001

Current biology : CB

Gap junction protein connexin-43 interacts directly with microtubules.

04-09-2001

Drug development and industrial pharmacy

Development of a lyophilized parenteral pharmaceutical formulation of the investigational polypeptide marine anticancer agent kahalalide F.

01-09-2001

Clinical pharmacokinetics

Population pharmacokinetics of ifosfamide and its dechloroethylated and hydroxylated metabolites in children with malignant disease: a sparse sampling approach.

29-08-2001

PDA journal of pharmaceutical science and technology

In vitro hemolysis and buffer capacity studies with the novel marine anticancer agent kahalalide F and its reconstitution vehicle cremophor EL/ethanol.

17-08-2001

Journal of chromatography. B, Biomedical sciences and applications

Bioanalysis and preliminary pharmacokinetics of the acridonecarboxamide derivative GF120918 in plasma of mice and humans by ion-pairing reversed-phase high-performance liquid chromatography with fluorescence detection.

05-08-2001

Clinical pharmacology and therapeutics

Modulation of the cytochrome P450-mediated metabolism of ifosfamide by ketoconazole and rifampin.

01-08-2001

Blood

Differentiation of cytomegalovirus-specific CD8(+) T cells in healthy and immunosuppressed virus carriers.

01-08-2001

Anti-cancer drugs

Pharmacokinetics of oral cyclosporin A when co-administered to enhance the oral absorption of paclitaxel.

01-08-2001

Proceedings of the National Academy of Sciences of the United States of America

Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells.

31-07-2001

Journal of immunology (Baltimore, Md. : 1950)

Regulation of MHC class II antigen presentation by sorting of recycling HLA-DM/DO and class II within the multivesicular body.

15-07-2001

Drug metabolism and disposition: the biological fate of chemicals

Influence of dose and infusion duration on pharmacokinetics of ifosfamide and metabolites.

Cancer chemotherapy and pharmacology

Population pharmacokinetics of ifosfamide and its 2- and 3-dechloroethylated and 4-hydroxylated metabolites in resistant small-cell lung cancer patients.

Bone marrow transplantation

Phase II study of a multi-course high-dose chemotherapy regimen incorporating cyclophosphamide, thiotepa, and carboplatin in stage IV breast cancer.

European journal of clinical pharmacology

Pharmacokinetics of oral cyclosporin A when co-administered to enhance the absorption of orally administered docetaxel.

Journal of chromatography. B, Biomedical sciences and applications

Sensitive gas chromatographic determination of the cyclophosphamide metabolite 2-dechloroethylcyclophosphamide in human plasma.

15-06-2001

Cancer chemotherapy and pharmacology

Successful rescue with leucovorin and thymidine in a patient with high-dose methotrexate induced acute renal failure.

Journal of pharmacokinetics and pharmacodynamics

A mechanism-based pharmacokinetic model for the cytochrome P450 drug-drug interaction between cyclophosphamide and thioTEPA and the autoinduction of cyclophosphamide.

Journal of cell science

c-Cbl ubiquitinates the EGF receptor at the plasma membrane and remains receptor associated throughout the endocytic route.

Journal of cell science

The interaction of plectin with actin: evidence for cross-linking of actin filaments by dimerization of the actin-binding domain of plectin.

Biochimica et biophysica acta

Checking out the G(2)/M transition.

28-05-2001

Nature

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors.

17-05-2001

The Journal of biological chemistry

Monitoring agonist-induced phospholipase C activation in live cells by fluorescence resonance energy transfer.

04-05-2001

Investigational new drugs

Progress in the development of alternative pharmaceutical formulations of taxanes.

Investigational new drugs

Oral delivery of taxanes.

European journal of cancer (Oxford, England : 1990)

Extensive cytoreductive surgery followed by intra-operative hyperthermic intraperitoneal chemotherapy with mitomycin-C in patients with peritoneal carcinomatosis of colorectal origin.

Patient education and counseling

Psychosocial care in family cancer clinics in The Netherlands: a brief report.

Biochimica et biophysica acta

Structural and functional aspects of filamins.

23-04-2001

Cancer research

Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues.

15-04-2001

Journal of chromatography. B, Biomedical sciences and applications

Degradation kinetics of aplidine, a new marine antitumoural cyclic peptide, in aqueous solution.

15-04-2001

Anti-cancer drugs

Phase I clinical and pharmacokinetic study of PNU166945, a novel water-soluble polymer-conjugated prodrug of paclitaxel.

Biopharmaceutics & drug disposition

Distribution of ifosfamide and metabolites between plasma and erythrocytes.

International journal of radiation oncology, biology, physics

Apoptosis, proliferation and p53, cyclin D1, and retinoblastoma gene expression in relation to radiation response in transitional cell carcinoma of the bladder.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy

Does resistance to apoptosis affect clinical response to antitumor drugs?

EMBO reports

A highly efficient ligand-regulated Cre recombinase mouse line shows that LoxP recombination is position dependent.

International journal of radiation oncology, biology, physics

Accurate in vivo dosimetry of a randomized trial of prostate cancer irradiation.

Cancer chemotherapy and pharmacology

A phase I and pharmacokinetic study of bi-daily dosing of oral paclitaxel in combination with cyclosporin A.

Anti-cancer drugs

The effect of different doses of cyclosporin A on the systemic exposure of orally administered paclitaxel.

Molecular pharmacology

P-glycoprotein limits oral availability, brain, and fetal penetration of saquinavir even with high doses of ritonavir.

Clinical cancer research : an official journal of the American Association for Cancer Research

Circumvention of breast cancer resistance protein (BCRP)-mediated resistance to camptothecins in vitro using non-substrate drugs or the BCRP inhibitor GF120918.