Publications

Cancer chemotherapy and pharmacology

A comparison of limited sampling strategies for prediction of Ecteinascidin 743 clearance when administered as a 24-h infusion.

Nature genetics

Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.

Therapeutic drug monitoring

Validation of a therapeutic drug monitoring strategy for thiotepa in a high-dose chemotherapy regimen.

British journal of cancer

The co-solvent Cremophor EL limits absorption of orally administered paclitaxel in cancer patients.

16-11-2001

Genes & development

Haplo-insufficiency? Let me count the ways.

15-11-2001

The Journal of biological chemistry

Inhibition of Polo-like kinase-1 by DNA damage occurs in an ATM- or ATR-dependent fashion.

09-11-2001

Journal of chromatography. B, Biomedical sciences and applications

High-performance liquid chromatographic analysis for the determination of a novel polymer-bound camptothecin derivative (MAG-camptothecin) and free camptothecin in human plasma.

05-11-2001

Journal of chromatography. B, Biomedical sciences and applications

Determination of cyclosporin A in human and mouse plasma by reversed-phase high-performance liquid chromatography.

05-11-2001

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Prognostic factors in transitional cell cancer of the bladder: an emerging role for Bcl-2 and p53.

01-11-2001

Biochemical Society transactions

Sphingolipids related to apoptosis from the point of view of membrane structure and topology.

01-11-2001

Human reproduction (Oxford, England)

Risk of cancer in the offspring of women who underwent ovarian stimulation for IVF.

01-11-2001

Current biology : CB

The Rab7 effector protein RILP controls lysosomal transport by inducing the recruitment of dynein-dynactin motors.

30-10-2001

Oncogene

Mouse model for lung tumorigenesis through Cre/lox controlled sporadic activation of the K-Ras oncogene.

04-10-2001

Journal of the National Cancer Institute

Complexity of lung cancer modifiers: mapping of thirty genes and twenty-five interactions in half of the mouse genome.

03-10-2001

Nature immunology

Immunotherapy through TCR gene transfer.

Journal of immunology (Baltimore, Md. : 1950)

Low-avidity self-specific T cells display a pronounced expansion defect that can be overcome by altered peptide ligands.

Journal of immunology (Baltimore, Md. : 1950)

Redundancy of direct priming and cross-priming in tumor-specific CD8+ T cell responses.

Acta crystallographica. Section D, Biological crystallography

ARP/wARP and molecular replacement.

Cancer letters

B-myb rescues ras-induced premature senescence, which requires its transactivation domain.

28-09-2001

Investigational new drugs

Compatibility and stability of the investigational polypeptide marine anticancer agent kahalalide F in infusion devices.

20-09-2001

Genes & development

Bidirectional action of the Igf2r imprint control element on upstream and downstream imprinted genes.

15-09-2001

Nature

Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice.

06-09-2001

Current biology : CB

Gap junction protein connexin-43 interacts directly with microtubules.

04-09-2001

Drug development and industrial pharmacy

Development of a lyophilized parenteral pharmaceutical formulation of the investigational polypeptide marine anticancer agent kahalalide F.

01-09-2001

Clinical pharmacokinetics

Population pharmacokinetics of ifosfamide and its dechloroethylated and hydroxylated metabolites in children with malignant disease: a sparse sampling approach.

29-08-2001

PDA journal of pharmaceutical science and technology

In vitro hemolysis and buffer capacity studies with the novel marine anticancer agent kahalalide F and its reconstitution vehicle cremophor EL/ethanol.

17-08-2001

Journal of chromatography. B, Biomedical sciences and applications

Bioanalysis and preliminary pharmacokinetics of the acridonecarboxamide derivative GF120918 in plasma of mice and humans by ion-pairing reversed-phase high-performance liquid chromatography with fluorescence detection.

05-08-2001

Clinical pharmacology and therapeutics

Modulation of the cytochrome P450-mediated metabolism of ifosfamide by ketoconazole and rifampin.

01-08-2001

Blood

Differentiation of cytomegalovirus-specific CD8(+) T cells in healthy and immunosuppressed virus carriers.

01-08-2001

Anti-cancer drugs

Pharmacokinetics of oral cyclosporin A when co-administered to enhance the oral absorption of paclitaxel.

01-08-2001

Proceedings of the National Academy of Sciences of the United States of America

Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells.

31-07-2001

Journal of immunology (Baltimore, Md. : 1950)

Regulation of MHC class II antigen presentation by sorting of recycling HLA-DM/DO and class II within the multivesicular body.

15-07-2001

Drug metabolism and disposition: the biological fate of chemicals

Influence of dose and infusion duration on pharmacokinetics of ifosfamide and metabolites.

Cancer chemotherapy and pharmacology

Population pharmacokinetics of ifosfamide and its 2- and 3-dechloroethylated and 4-hydroxylated metabolites in resistant small-cell lung cancer patients.

Bone marrow transplantation

Phase II study of a multi-course high-dose chemotherapy regimen incorporating cyclophosphamide, thiotepa, and carboplatin in stage IV breast cancer.

European journal of clinical pharmacology

Pharmacokinetics of oral cyclosporin A when co-administered to enhance the absorption of orally administered docetaxel.

Journal of chromatography. B, Biomedical sciences and applications

Sensitive gas chromatographic determination of the cyclophosphamide metabolite 2-dechloroethylcyclophosphamide in human plasma.

15-06-2001

Cancer chemotherapy and pharmacology

Successful rescue with leucovorin and thymidine in a patient with high-dose methotrexate induced acute renal failure.

Journal of pharmacokinetics and pharmacodynamics

A mechanism-based pharmacokinetic model for the cytochrome P450 drug-drug interaction between cyclophosphamide and thioTEPA and the autoinduction of cyclophosphamide.

Journal of cell science

c-Cbl ubiquitinates the EGF receptor at the plasma membrane and remains receptor associated throughout the endocytic route.

Journal of cell science

The interaction of plectin with actin: evidence for cross-linking of actin filaments by dimerization of the actin-binding domain of plectin.