Publications

Anti-cancer drugs

Clinical pharmacology of the novel marine-derived anticancer agent Ecteinascidin 743 administered as a 1- and 3-h infusion in a phase I study.

Nature reviews. Cancer

Conditional mouse models of sporadic cancer.

Molecular cancer therapeutics

Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C.

Cancer chemotherapy and pharmacology

Population pharmacokinetics of the novel anticancer agent KRN7000.

Lancet (London, England)

Hypospadias in sons of women exposed to diethylstilbestrol in utero: a cohort study.

30-03-2002

Cancer letters

Convergence of mitogenic and DNA damage signaling in the G1 phase of the cell cycle.

28-03-2002

Nederlands tijdschrift voor geneeskunde

[The concomitant use of radiotherapy and chemotherapy for the treatment of solid malignant tumors].

16-03-2002

Journal of cell science

Association of the tetraspanin CD151 with the laminin-binding integrins alpha3beta1, alpha6beta1, alpha6beta4 and alpha7beta1 in cells in culture and in vivo.

15-03-2002

Cancer research

Noninvasive imaging of spontaneous retinoblastoma pathway-dependent tumors in mice.

15-03-2002

Genes & development

A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling.

15-03-2002

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

Diagnosis and treatment of isolated neck metastases of adenocarcinomas.

Genes to cells : devoted to molecular & cellular mechanisms

The FYVE domain in Smad anchor for receptor activation (SARA) is sufficient for localization of SARA in early endosomes and regulates TGF-beta/Smad signalling.

Annals of oncology : official journal of the European Society for Medical Oncology

Relationship between exposure and toxicity in high-dose chemotherapy with cyclophosphamide, thiotepa and carboplatin.

Cancer chemotherapy and pharmacology

Phase I and pharmacokinetic study of SPI-77, a liposomal encapsulated dosage form of cisplatin.

The Journal of biological chemistry

TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence.

22-02-2002

Biologicals : journal of the International Association of Biological Standardization

Circumventing T-cell tolerance to tumour antigens.

20-02-2002

Acta oncologica (Stockholm, Sweden)

Radiation nephropathy--the link between functional damage and vascular mediated inflammatory and thrombotic changes.

16-02-2002

Acta oncologica (Stockholm, Sweden)

Hypoxia and perfusion measurements in human tumors--initial experience with pimonidazole and IUdR.

16-02-2002

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Role of health-related quality of life in palliative chemotherapy treatment decisions.

15-02-2002

Cancer chemotherapy and pharmacology

Entrapment by Cremophor EL decreases the absorption of paclitaxel from the gut.

01-02-2002

Nature cell biology

A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence.

01-02-2002

Nature

Gene expression profiling predicts clinical outcome of breast cancer.

31-01-2002

The Journal of cell biology

Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits.

21-01-2002

Journal of immunology (Baltimore, Md. : 1950)

Can the low-avidity self-specific T cell repertoire be exploited for tumor rejection?

15-01-2002

Advances in experimental medicine and biology

The roles of P-glycoprotein and MRP1 in the blood-brain and blood-cerebrospinal fluid barriers.

05-01-2002

Anti-cancer drugs

Topoisomerase I levels in white blood cells of patients with ovarian cancer treated with paclitaxel-cisplatin-topotecan in a phase I study.

01-01-2002

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Increased risk of ischemic stroke after radiotherapy on the neck in patients younger than 60 years.

01-01-2002

European journal of cancer (Oxford, England : 1990)

The combined use of radiotherapy and chemotherapy in the treatment of solid tumours.

01-01-2002

The Journal of biological chemistry

Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3).

07-12-2001

The Journal of investigative dermatology

Two different mutations in the cytoplasmic domain of the integrin beta 4 subunit in nonlethal forms of epidermolysis bullosa prevent interaction of beta 4 with plectin.

Cancer chemotherapy and pharmacology

A comparison of limited sampling strategies for prediction of Ecteinascidin 743 clearance when administered as a 24-h infusion.

Nature genetics

Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.

Therapeutic drug monitoring

Validation of a therapeutic drug monitoring strategy for thiotepa in a high-dose chemotherapy regimen.