Publications

Nature cell biology

Escape from premature senescence is not sufficient for oncogenic transformation by Ras.

International journal of radiation oncology, biology, physics

Alkyl-lysophospholipids as anticancer agents and enhancers of radiation-induced apoptosis.

Current opinion in structural biology

DNA mismatch repair: MutS structures bound to mismatches.

Biochemical and biophysical research communications

Effect of overexpression of a neutral sphingomyelinase on CD95-induced ceramide production and apoptosis.

26-01-2001

Current biology : CB

Galpha(13) mediates activation of a depolarizing chloride current that accompanies RhoA activation in both neuronal and nonneuronal cells.

23-01-2001

British journal of cancer

Co-administration of GF120918 significantly increases the systemic exposure to oral paclitaxel in cancer patients.

05-01-2001

Current oncology reports

Concurrent chemotherapy and radiation for locally advanced squamous cell cancers: what is the schedule of choice?

Journal of neuro-oncology

Neurophysiological evaluation of late effects of adjuvant high-dose chemotherapy on cognitive function.

British journal of clinical pharmacology

Population pharmacokinetics of thioTEPA and its active metabolite TEPA in patients undergoing high-dose chemotherapy.

Clinical pharmacokinetics

Clinical pharmacokinetics and pharmacodynamics of ifosfamide and its metabolites.

The Journal of cell biology

Dual stimulation of Ras/mitogen-activated protein kinase and RhoA by cell adhesion to fibronectin supports growth factor-stimulated cell cycle progression.

25-12-2000

Proceedings of the National Academy of Sciences of the United States of America

Changing T cell specificity by retroviral T cell receptor display.

19-12-2000

Clinical cancer research : an official journal of the American Association for Cancer Research

Pharmacokinetics and pharmacodynamics of the novel marine-derived anticancer agent ecteinascidin 743 in a phase I dose-finding study.

01-12-2000

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Modulation of oral bioavailability of anticancer drugs: from mouse to man.

01-12-2000

The Journal of biological chemistry

Glucosylceramide synthase does not attenuate the ceramide pool accumulating during apoptosis induced by CD95 or anti-cancer regimens.

03-11-2000

Nature immunology

CD27 is required for generation and long-term maintenance of T cell immunity.

Anti-cancer drugs

Metabolism and excretion of paclitaxel after oral administration in combination with cyclosporin A and after i.v. administration.

Anti-cancer drugs

Pharmaceutical development of anticancer agents derived from marine sources.

Clinical cancer research : an official journal of the American Association for Cancer Research

Increased oral bioavailability of paclitaxel by GF120918 in mice through selective modulation of P-glycoprotein.

Nature genetics

Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers.

Clinical pharmacokinetics

Pharmacokinetically guided administration of chemotherapeutic agents.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

Extensive cytoreductive surgery combined with intra-operative intraperitoneal perfusion with cisplatin under hyperthermic conditions (OVHIPEC) in patients with recurrent ovarian cancer: a feasibility pilot.

Journal of the National Cancer Institute

Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan.

18-10-2000

Cancer research

Extensive contribution of the multidrug transporters P-glycoprotein and Mrp1 to basal drug resistance.

15-10-2000

Nature

The crystal structure of DNA mismatch repair protein MutS binding to a G x T mismatch.

12-10-2000

Oncogene

p27kip1-independent cell cycle regulation by MYC.

05-10-2000

Cancer gene therapy

Lymphoid abnormalities in CD40 ligand transgenic mice suggest the need for tight regulation in gene therapy approaches to hyper immunoglobulin M (IgM) syndrome

Therapeutic drug monitoring

Determination of ifosfamide, 2- and 3-dechloroethyifosfamide using gas chromatography with nitrogen-phosphorus or mass spectrometry detection.

Radiation research

In vitro and in vivo expression of endothelial von Willebrand factor and leukocyte accumulation after fractionated irradiation.

Anti-cancer drugs

Cremophor EL pharmacokinetics in a phase I study of paclitaxel (Taxol) and carboplatin in non-small cell lung cancer patients.