Detail of the structure of the Autotaxin protein (green), a drug target, bound to a potential drug lead (brown) and its substrate (blue

Anastassis (Tassos) Perrakis

Macromolecular Structures

Macromolecular structures are critical for understanding the chemistry of life: the interaction of proteins, nucleic acids, carbohydrates and lipids, which can help us understand the function of cells and to develop new drugs.

We integrate X-ray crystallography and small angle scattering, cryo-EM, and NMR with biochemical and biophysical methods in vitro and in cells, to link the function and structure of macromolecules relevant for cancer. Concurrently we work on methodological developments that enable specific software tools to determine macromolecular structures better and faster.

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