Robbie P. Joosten

My research focusses on developing new computational methods to validate and improve the quality of macromolecular structure models. Within the PDB-REDO project (pdb-redo.eu) we take experimental data and initial models from crystal diffraction experiments, and improve the fit with the data and remove model errors. This approach delivers high-quality structure model for downstream studies such as drug (lead) discovery and structure-function analyses of proteins.