Publications

Cancer chemotherapy and pharmacology

Population pharmacokinetics of ifosfamide and its 2- and 3-dechloroethylated and 4-hydroxylated metabolites in resistant small-cell lung cancer patients.

Bone marrow transplantation

Phase II study of a multi-course high-dose chemotherapy regimen incorporating cyclophosphamide, thiotepa, and carboplatin in stage IV breast cancer.

European journal of clinical pharmacology

Pharmacokinetics of oral cyclosporin A when co-administered to enhance the absorption of orally administered docetaxel.

Journal of chromatography. B, Biomedical sciences and applications

Sensitive gas chromatographic determination of the cyclophosphamide metabolite 2-dechloroethylcyclophosphamide in human plasma.

15-06-2001

Cancer chemotherapy and pharmacology

Successful rescue with leucovorin and thymidine in a patient with high-dose methotrexate induced acute renal failure.

Journal of pharmacokinetics and pharmacodynamics

A mechanism-based pharmacokinetic model for the cytochrome P450 drug-drug interaction between cyclophosphamide and thioTEPA and the autoinduction of cyclophosphamide.

Journal of cell science

c-Cbl ubiquitinates the EGF receptor at the plasma membrane and remains receptor associated throughout the endocytic route.

Journal of cell science

The interaction of plectin with actin: evidence for cross-linking of actin filaments by dimerization of the actin-binding domain of plectin.

Biochimica et biophysica acta

Checking out the G(2)/M transition.

28-05-2001

Nature

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors.

17-05-2001

The Journal of biological chemistry

Monitoring agonist-induced phospholipase C activation in live cells by fluorescence resonance energy transfer.

04-05-2001

Investigational new drugs

Progress in the development of alternative pharmaceutical formulations of taxanes.

Investigational new drugs

Oral delivery of taxanes.

European journal of cancer (Oxford, England : 1990)

Extensive cytoreductive surgery followed by intra-operative hyperthermic intraperitoneal chemotherapy with mitomycin-C in patients with peritoneal carcinomatosis of colorectal origin.

Patient education and counseling

Psychosocial care in family cancer clinics in The Netherlands: a brief report.

Biochimica et biophysica acta

Structural and functional aspects of filamins.

23-04-2001

Cancer research

Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues.

15-04-2001

Journal of chromatography. B, Biomedical sciences and applications

Degradation kinetics of aplidine, a new marine antitumoural cyclic peptide, in aqueous solution.

15-04-2001

Anti-cancer drugs

Phase I clinical and pharmacokinetic study of PNU166945, a novel water-soluble polymer-conjugated prodrug of paclitaxel.

Biopharmaceutics & drug disposition

Distribution of ifosfamide and metabolites between plasma and erythrocytes.

International journal of radiation oncology, biology, physics

Apoptosis, proliferation and p53, cyclin D1, and retinoblastoma gene expression in relation to radiation response in transitional cell carcinoma of the bladder.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy

Does resistance to apoptosis affect clinical response to antitumor drugs?

EMBO reports

A highly efficient ligand-regulated Cre recombinase mouse line shows that LoxP recombination is position dependent.

International journal of radiation oncology, biology, physics

Accurate in vivo dosimetry of a randomized trial of prostate cancer irradiation.

Cancer chemotherapy and pharmacology

A phase I and pharmacokinetic study of bi-daily dosing of oral paclitaxel in combination with cyclosporin A.

Anti-cancer drugs

The effect of different doses of cyclosporin A on the systemic exposure of orally administered paclitaxel.

Molecular pharmacology

P-glycoprotein limits oral availability, brain, and fetal penetration of saquinavir even with high doses of ritonavir.

Clinical cancer research : an official journal of the American Association for Cancer Research

Circumvention of breast cancer resistance protein (BCRP)-mediated resistance to camptothecins in vitro using non-substrate drugs or the BCRP inhibitor GF120918.

Toxicology letters

The importance of drug-transporting P-glycoproteins in toxicology.

31-03-2001

JAMA

The patient-physician relationship. Patient-physician communication during outpatient palliative treatment visits: an observational study.

14-03-2001

Experimental cell research

Mouse models for sporadic cancer.

10-03-2001

Nederlands tijdschrift voor geneeskunde

[Save or destroy? The importance of medical record for former patients and future patients].

10-03-2001

Anti-cancer drugs

Ras biochemistry and farnesyl transferase inhibitors: a literature survey.

01-03-2001

Studies in health technology and informatics

The development of a new information model for a pediatric cancer registry on late treatment sequelae in The Netherlands.

24-02-2001

Annals of the New York Academy of Sciences

Transport of topoisomerase I inhibitors by the breast cancer resistance protein. Potential clinical implications.

24-02-2001

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Coadministration of cyclosporine strongly enhances the oral bioavailability of docetaxel.

15-02-2001

Journal of immunology (Baltimore, Md. : 1950)

A redundant role of the CD3 gamma-immunoreceptor tyrosine-based activation motif in mature T cell function.

15-02-2001

The Journal of urology

Comparison of patient and spouse assessments of health related quality of life in men with metastatic prostate cancer.

Nature cell biology

Escape from premature senescence is not sufficient for oncogenic transformation by Ras.

International journal of radiation oncology, biology, physics

Alkyl-lysophospholipids as anticancer agents and enhancers of radiation-induced apoptosis.

Current opinion in structural biology

DNA mismatch repair: MutS structures bound to mismatches.

Biochemical and biophysical research communications

Effect of overexpression of a neutral sphingomyelinase on CD95-induced ceramide production and apoptosis.

26-01-2001

Current biology : CB

Galpha(13) mediates activation of a depolarizing chloride current that accompanies RhoA activation in both neuronal and nonneuronal cells.

23-01-2001

British journal of cancer

Co-administration of GF120918 significantly increases the systemic exposure to oral paclitaxel in cancer patients.

05-01-2001

Current oncology reports

Concurrent chemotherapy and radiation for locally advanced squamous cell cancers: what is the schedule of choice?

Journal of neuro-oncology

Neurophysiological evaluation of late effects of adjuvant high-dose chemotherapy on cognitive function.

British journal of clinical pharmacology

Population pharmacokinetics of thioTEPA and its active metabolite TEPA in patients undergoing high-dose chemotherapy.

Clinical pharmacokinetics

Clinical pharmacokinetics and pharmacodynamics of ifosfamide and its metabolites.