Publications

Leukemia research

Increased Rac activity is required for the progression of T-lymphomas induced by Pten-deficiency.

The oncologist

Application of PET/CT in the development of novel anticancer drugs.

Cancer cell

Targeted anticancer therapies: mouse models help uncover the mechanisms of tumor escape.

International journal of radiation oncology, biology, physics

Adaptive radiotherapy for prostate cancer using kilovoltage cone-beam computed tomography: first clinical results.

Anti-cancer drugs

Alkylphospholipids inhibit capillary-like endothelial tube formation in vitro: antiangiogenic properties of a new class of antitumor agents.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Brain metastases in patients with renal cell cancer receiving new targeted treatment.

Nuclear medicine communications

99mTc-HYNIC-rh-annexin-V scintigraphy: visual and quantitative evaluation of early treatment-induced apoptosis to predict treatment outcome.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

3D in vivo dose verification of entire hypo-fractionated IMRT treatments using an EPID and cone-beam CT.

Clinical medicine. Oncology

Radionuclide Imaging of Apoptosis in Malignancies: Promise and Pitfalls of Tc-Hynic-rh-Annexin V Imaging.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy

Modeling therapy resistance in genetically engineered mouse cancer models.

Acta crystallographica. Section D, Biological crystallography

ARP/wARP and molecular replacement: the next generation.

Blood

Treatment-related risk factors for premature menopause following Hodgkin lymphoma.

The Journal of cell biology

Apoptosis induction by Bid requires unconventional ubiquitination and degradation of its N-terminal fragment.

31-12-2007

Cell

RNA-binding protein Dnd1 inhibits microRNA access to target mRNA.

28-12-2007

The EMBO journal

Localized H3K36 methylation states define histone H4K16 acetylation during transcriptional elongation in Drosophila.

12-12-2007

PLoS genetics

A RNA interference screen identifies the protein phosphatase 2A subunit PR55gamma as a stress-sensitive inhibitor of c-SRC.

The Lancet. Oncology

Use of 70-gene signature to predict prognosis of patients with node-negative breast cancer: a prospective community-based feasibility study (RASTER).

Molecular cancer therapeutics

In vitro transport of gimatecan (7-t-butoxyiminomethylcamptothecin) by breast cancer resistance protein, P-glycoprotein, and multidrug resistance protein 2.

International journal of radiation oncology, biology, physics

A phase I-II study of postoperative capecitabine-based chemoradiotherapy in gastric cancer.

Current opinion in structural biology

Protein-protein interactions regulate Ubl conjugation.

International journal of radiation oncology, biology, physics

Strategy for online correction of rotational organ motion for intensity-modulated radiotherapy of prostate cancer.

Breast (Edinburgh, Scotland)

Explanatory factors for variation in the use of breast conserving surgery and radiotherapy in the Netherlands, 1990-2001.

Head & neck

Heterogeneity of gene expression profiles in head and neck cancer.

International journal of radiation oncology, biology, physics

Gene expression profiling to predict outcome after chemoradiation in head and neck cancer.

Nature

Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1.

29-11-2007

Clinical pharmacokinetics

Population pharmacokinetics and pharmacodynamics of doxorubicin and cyclophosphamide in breast cancer patients: a study by the EORTC-PAMM-NDDG.

22-11-2007

Rapid communications in mass spectrometry : RCM

Development and validation of an assay for the quantitative determination of cladribine nucleotides in MDCKII cells and culture medium using weak anion-exchange liquid chromatography coupled with tandem mass spectrometry.

17-11-2007

Cell cycle (Georgetown, Tex.)

What makes tumors multidrug resistant?

Blood

Selecting highly affine and well-expressed TCRs for gene therapy of melanoma.

Cell cycle (Georgetown, Tex.)

Diverse ways to control p27Kip1 function: miRNAs come into play.

Biochemical pharmacology

Lipid rafts and metabolic energy differentially determine uptake of anti-cancer alkylphospholipids in lymphoma versus carcinoma cells.

Proceedings of the National Academy of Sciences of the United States of America

A functional genetic screen identifies retinoic acid signaling as a target of histone deacetylase inhibitors.

06-11-2007

Clinical cancer research : an official journal of the American Association for Cancer Research

Population pharmacokinetics and pharmacodynamics of paclitaxel and carboplatin in ovarian cancer patients: a study by the European organization for research and treatment of cancer-pharmacology and molecular mechanisms group and new drug development group.

Breast cancer research and treatment

Impact of a programme of mass mammography screening for breast cancer on socio-economic variation in survival: a population-based study.

Molecular biology of the cell

Dual Role of alpha6beta4 integrin in epidermal tumor growth: tumor-suppressive versus tumor-promoting function.

British journal of clinical pharmacology

Safety and pharmacology of paclitaxel in patients with impaired liver function: a population pharmacokinetic-pharmacodynamic study.

The Journal of clinical investigation

Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism.

The American journal of clinical nutrition

Lycopene supplementation elevates circulating insulin-like growth factor binding protein-1 and -2 concentrations in persons at greater risk of colorectal cancer.

Biomedical chromatography : BMC

Determination of topotecan in human and mouse plasma and in mouse tissue homogenates by reversed-phase high-performance liquid chromatography.

Clinical cancer research : an official journal of the American Association for Cancer Research

P-glycoprotein and breast cancer resistance protein: two dominant transporters working together in limiting the brain penetration of topotecan.