Publications

The Journal of clinical investigation

Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism.

The American journal of clinical nutrition

Lycopene supplementation elevates circulating insulin-like growth factor binding protein-1 and -2 concentrations in persons at greater risk of colorectal cancer.

Biomedical chromatography : BMC

Determination of topotecan in human and mouse plasma and in mouse tissue homogenates by reversed-phase high-performance liquid chromatography.

Clinical cancer research : an official journal of the American Association for Cancer Research

P-glycoprotein and breast cancer resistance protein: two dominant transporters working together in limiting the brain penetration of topotecan.

Cell

Retinoblastoma teaches a new lesson.

19-10-2007

Acta oncologica (Stockholm, Sweden)

Cognitive complaints and cognitive impairment following BEP chemotherapy in patients with testicular cancer.

16-10-2007

Breast cancer research : BCR

Gene expression profiling and histopathological characterization of triple-negative/basal-like breast carcinomas.

04-10-2007

Hematology/oncology clinics of North America

Are we improving the long-term burden of Hodgkin's lymphoma patients with modern treatment?

Cancer cell

A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Treatment-specific risks of second malignancies and cardiovascular disease in 5-year survivors of testicular cancer.

The Lancet. Oncology

Cognitive dysfunction in people with cancer.

Cancer cell

Bmi1 controls tumor development in an Ink4a/Arf-independent manner in a mouse model for glioma.

Journal of cell science

Requirements for the localization of nesprin-3 at the nuclear envelope and its interaction with plectin.

Cancer chemotherapy and pharmacology

Novel paclitaxel formulations for oral application: a phase I pharmacokinetic study in patients with solid tumours.

European journal of cancer (Oxford, England : 1990)

Survival of elderly rectal cancer patients not improved: analysis of population based data on the impact of TME surgery.

European journal of cancer (Oxford, England : 1990)

COPD in cancer patients: higher prevalence in the elderly, a different treatment strategy in case of primary tumours above the diaphragm, and a worse overall survival in the elderly patient.

Cancer research

Do MDM2 SNP309 and TP53 R72P interact in breast cancer susceptibility? A large pooled series from the breast cancer association consortium.

European journal of cancer (Oxford, England : 1990)

Health-related quality of life and health care utilisation among older long-term cancer survivors: a population-based study.

Physiol Genomics: Physiological genomics

Toxicity of ligand-dependent Cre recombinases and generation of a conditional Cre deleter mouse allowing mosaic recombination in peripheral tissues

19-09-2007

British journal of cancer

Postoperative chemoradiotherapy in gastric cancer -- a Phase I/II dose-finding study of radiotherapy with dose escalation of cisplatin and capecitabine chemotherapy.

17-09-2007

Molecular biology of the cell

Serine phosphorylation of the integrin beta4 subunit is necessary for epidermal growth factor receptor induced hemidesmosome disruption.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

Survival after negative sentinel lymph node biopsy in breast cancer at least equivalent to after negative extensive axillary dissection.

Breast cancer research and treatment

Margin status and the risk of local recurrence after breast-conserving treatment of lobular breast cancer.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Quantitative and selective assay of 5-methylindirubine, an inhibitor of cyclin-dependent kinases, in murine plasma using coupled liquid chromatography and electrospray tandem mass spectrometry.

Journal of mammary gland biology and neoplasia

Modeling metastatic breast cancer in mice.

International journal of radiation oncology, biology, physics

Impact of external beam adjuvant radiotherapy on health-related quality of life for long-term survivors of endometrial adenocarcinoma: a population-based study.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Oral contraceptives and breast cancer risk in the international BRCA1/2 carrier cohort study: a report from EMBRACE, GENEPSO, GEO-HEBON, and the IBCCS Collaborating Group.

Cancer letters

Absence of lymphangiogenesis in ductal breast cancer at the primary tumor site.

28-08-2007

Nucleic acids research

Functional characterization of Rad18 domains for Rad6, ubiquitin, DNA binding and PCNA modification.

28-08-2007

Journal of health organization and management

Strategic behaviour of institutional providers in mental handicapped care in the Netherlands.

24-08-2007

Nature

p15Ink4b is a critical tumour suppressor in the absence of p16Ink4a.

23-08-2007

Molecular pharmaceutics

Profiling proteasome activity in tissue with fluorescent probes.

22-08-2007

Advances in experimental medicine and biology

A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors.

19-08-2007

Blood

In vivo p53 response and immune reaction underlie highly effective low-dose radiotherapy in follicular lymphoma.

15-08-2007

International journal of cancer

Increased health care utilization among long-term cancer survivors compared to the average Dutch population: a population-based study.

15-08-2007

Journal of immunology (Baltimore, Md. : 1950)

In vivo antigen stability affects DNA vaccine immunogenicity.

15-08-2007

The EMBO journal

PKA-induced resistance to tamoxifen is associated with an altered orientation of ERalpha towards co-activator SRC-1.

08-08-2007

The EMBO journal

Regulation of the p27(Kip1) tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferation.

08-08-2007

The Journal of experimental medicine

A/T mutagenesis in hypermutated immunoglobulin genes strongly depends on PCNAK164 modification.

06-08-2007

AAPS PharmSciTech

Development of a bladder instillation of the indoloquinone anticancer agent EO-9 using tert-butyl alcohol as lyophilization vehicle.

03-08-2007

Investigational new drugs

Human mass balance study of the novel anticancer agent ixabepilone using accelerator mass spectrometry.

Clinical cancer research : an official journal of the American Association for Cancer Research

Phase I pharmacokinetic and pharmacodynamic study of the oral protein kinase C beta-inhibitor enzastaurin in combination with gemcitabine and cisplatin in patients with advanced cancer.

Minerva ginecologica

Effects of hormonal therapy on cognitive functioning in breast cancer patients: a review of the literature.

The oncologist

Concise review: Clinical relevance of drug drug and herb drug interactions mediated by the ABC transporter ABCB1 (MDR1, P-glycoprotein).

Clinical cancer research : an official journal of the American Association for Cancer Research

Phase I pharmacokinetic study of the safety and tolerability of lapatinib (GW572016) in combination with oxaliplatin/fluorouracil/leucovorin (FOLFOX4) in patients with solid tumors.

Breast (Edinburgh, Scotland)

Trends in the prognosis of patients with primary metastatic breast cancer diagnosed between 1975 and 2002.

International archives of occupational and environmental health

Monitoring of platinum surface contamination in seven Dutch hospital pharmacies using inductively coupled plasma mass spectrometry.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

The health-related quality of life of long-term survivors of melanoma treated with isolated limb perfusion.

Molecular cancer therapeutics

A new class of anticancer alkylphospholipids uses lipid rafts as membrane gateways to induce apoptosis in lymphoma cells.