Publications

Molecular and cellular biology

Synthetic lethal screens identify gene silencing processes in yeast and implicate the acetylated amino terminus of Sir3 in recognition of the nucleosome core.

Nature structural & molecular biology

Nonprocessive methylation by Dot1 leads to functional redundancy of histone H3K79 methylation states.

Pharmacogenetics and genomics

Influence of polymorphisms of drug metabolizing enzymes (CYP2B6, CYP2C9, CYP2C19, CYP3A4, CYP3A5, GSTA1, GSTP1, ALDH1A1 and ALDH3A1) on the pharmacokinetics of cyclophosphamide and 4-hydroxycyclophosphamide.

Clinical cancer research : an official journal of the American Association for Cancer Research

Oral administration of gemcitabine in patients with refractory tumors: a clinical and pharmacologic study.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

A sensitive assay for the quantitative analysis of vinorelbine in mouse and human EDTA plasma by high-performance liquid chromatography coupled with electrospray tandem mass spectrometry.

Proteomics. Clinical applications

Influence of variations in sample handling on SELDI-TOF MS serum protein profiles for colorectal cancer.

PloS one

Ubiquitin E3 ligase Ring1b/Rnf2 of polycomb repressive complex 1 contributes to stable maintenance of mouse embryonic stem cells.

21-05-2008

Cell

Large-scale mutagenesis in p19(ARF)- and p53-deficient mice identifies cancer genes and their collaborative networks.

16-05-2008

Journal of immunology (Baltimore, Md. : 1950)

Long-term functionality of TCR-transduced T cells in vivo.

15-05-2008

Cell cycle (Georgetown, Tex.)

How do real tumors become resistant to cisplatin?

15-05-2008

Molecular cell

Cdc20 and Cks direct the spindle checkpoint-independent destruction of cyclin A.

09-05-2008

RNA (New York, N.Y.)

miR-148 targets human DNMT3b protein coding region.

Cancer chemotherapy and pharmacology

Cisplatin-DNA adduct formation in patients treated with cisplatin-based chemoradiation: lack of correlation between normal tissues and primary tumor.

Analytical and bioanalytical chemistry

Inductively coupled plasma mass spectrometric analysis of the total amount of platinum in DNA extracts from peripheral blood mononuclear cells and tissue from patients treated with cisplatin.

Journal of immunology (Baltimore, Md. : 1950)

An inducible caspase 9 safety switch can halt cell therapy-induced autoimmune disease.

Nutrition and cancer

Effects of lycopene on the insulin-like growth factor (IGF) system in premenopausal breast cancer survivors and women at high familial breast cancer risk.

30-04-2008

PloS one

The T7-primer is a source of experimental bias and introduces variability between microarray platforms.

23-04-2008

Cell division

The many faces of ubiquitinated histone H2A: insights from the DUBs.

22-04-2008

British journal of cancer

A dose-escalation study of indisulam in combination with capecitabine (Xeloda) in patients with solid tumours.

22-04-2008

Clinical cancer research : an official journal of the American Association for Cancer Research

Sunitinib for treatment of advanced renal cell cancer: primary tumor response.

15-04-2008

Cell

A tRNA with oncogenic capacity.

04-04-2008

PloS one

A comparison of donor-acceptor pairs for genetically encoded FRET sensors: application to the Epac cAMP sensor as an example.

02-04-2008

Cell cycle (Georgetown, Tex.)

Interplay between microRNAs and RNA-binding proteins determines developmental processes.

Acta crystallographica. Section D, Biological crystallography

A knowledge-driven approach for crystallographic protein model completion.

Drug metabolism and disposition: the biological fate of chemicals

Species-dependent transport and modulation properties of human and mouse multidrug resistance protein 2 (MRP2/Mrp2, ABCC2/Abcc2).

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Development and validation of a quantitative assay for the measurement of miltefosine in human plasma by liquid chromatography-tandem mass spectrometry.

The Journal of urology

The influence of cardiovascular disease on health related quality of life in men with prostate cancer: a 4-year followup study.

Current opinion in cell biology

Cellular senescence in vivo: a barrier to tumorigenesis.

Cancer research

Skewing the T-cell repertoire by combined DNA vaccination, host conditioning, and adoptive transfer.

Current opinion in cell biology

Stem cell regulation by polycomb repressors: postponing commitment.

Clinical drug investigation

Carboplatin dosage formulae can generate inaccurate predictions of Carboplatin exposure in carboplatin/paclitaxel combination regimens.

29-03-2008

PLoS genetics

Global chromatin domain organization of the Drosophila genome.

28-03-2008

Cell

Linking cohesin to gene regulation.

21-03-2008

International journal of radiation oncology, biology, physics

Comparison of different strategies to use four-dimensional computed tomography in treatment planning for lung cancer patients.

15-03-2008

Proceedings of the National Academy of Sciences of the United States of America

Conditional MHC class I ligands and peptide exchange technology for the human MHC gene products HLA-A1, -A3, -A11, and -B7.

11-03-2008

European journal of nuclear medicine and molecular imaging

99mTc Hynic-rh-Annexin V scintigraphy for in vivo imaging of apoptosis in patients with head and neck cancer treated with chemoradiotherapy.

European journal of cancer (Oxford, England : 1990)

Implementation of sentinel node biopsy in breast cancer patients in the Netherlands.

Nederlands tijdschrift voor geneeskunde

[The effect of hormone therapy on cognitive function in patients with breast cancer].

Molecular pharmacology

Midazolam metabolism in cytochrome P450 3A knockout mice can be attributed to up-regulated CYP2C enzymes.

Cancer cell

A conditional mouse model for malignant mesothelioma.

Antimicrobial agents and chemotherapy

P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.

The oncologist

Prolonged versus standard gemcitabine infusion: translation of molecular pharmacology to new treatment strategy.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

ERP amplitude and latency in breast cancer survivors treated with adjuvant chemotherapy.