Publications

Investigational new drugs

Trabectedin (ET-743, Yondelis) is a substrate for P-glycoprotein, but only high expression of P-glycoprotein confers the multidrug resistance phenotype.

Laboratory investigation; a journal of technical methods and pathology

Validation of SELDI-TOF MS serum protein profiles for renal cell carcinoma in new populations.

International journal of pharmaceutics

EO-9 bladder instillations: formulation selection based on stability characteristics and in vitro simulation studies.

The Journal of nutrition

Isolated isoflavones do not affect the circulating insulin-like growth factor system in men at increased colorectal cancer risk.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Predictors of prophylactic bilateral salpingo-oophorectomy compared with gynecologic screening use in BRCA1/2 mutation carriers.

20-01-2007

Experimental cell research

Direct measurement of cyclic AMP diffusion and signaling through connexin43 gap junctional channels.

15-01-2007

The Biochemical journal

Resistance to alkyl-lysophospholipid-induced apoptosis due to downregulated sphingomyelin synthase 1 expression with consequent sphingomyelin- and cholesterol-deficiency in lipid rafts.

15-01-2007

Journal of cell science

Synaptotagmin 3 deficiency in T cells impairs recycling of the chemokine receptor CXCR4 and thereby inhibits CXCL12 chemokine-induced migration.

15-01-2007

Physics in medicine and biology

Influence of the linac design on intensity-modulated radiotherapy of head-and-neck plans.

07-01-2007

The Journal of biological chemistry

Activation of TRPM7 channels by phospholipase C-coupled receptor agonists.

05-01-2007

Journal of pharmaceutical and biomedical analysis

Stability experiments in human urine with EO9 (apaziquone): a novel anticancer agent for the intravesical treatment of bladder cancer.

04-01-2007

BMC biotechnology

Intravital imaging of fluorescent markers and FRET probes by DNA tattooing.

03-01-2007

Am J Pathol: The American journal of pathology

Aneuploidy arises at early stages of Apc-driven intestinal tumorigenesis and pinpoints conserved chromosomal loci of allelic imbalance between mouse and human

Experimental cel research

Conditional inactivation of Brca1 in the mouse ovarian surface epithelium results in an increase in preneoplastic changes

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Breast cancer survival and tumor characteristics in premenopausal women carrying the CHEK2*1100delC germline mutation.

European journal of human genetics : EJHG

The single-nucleotide polymorphism 309 in the MDM2 gene contributes to the Li-Fraumeni syndrome and related phenotypes.

Molecular pharmacology

The effect of low pH on breast cancer resistance protein (ABCG2)-mediated transport of methotrexate, 7-hydroxymethotrexate, methotrexate diglutamate, folic acid, mitoxantrone, topotecan, and resveratrol in in vitro drug transport models.

World journal of surgery

Which comorbid conditions predict complications after surgery for colorectal cancer?

Cancer chemotherapy and pharmacology

A pharmacokinetic and safety study of a novel polymeric paclitaxel formulation for oral application.

Nederlands tijdschrift voor geneeskunde

[The Nobel Prize in Physiology or Medicine for 2006 for the discovery of RNA interference].

30-12-2006

The Journal of biological chemistry

Telomerase-independent regulation of ATR by human telomerase RNA.

29-12-2006

Journal of cell science

KASH-domain proteins in nuclear migration, anchorage and other processes.

15-12-2006

The New England journal of medicine

Exploring the uses of RNAi--gene knockdown and the Nobel Prize.

07-12-2006

Journal of the National Cancer Institute

Change in cognitive function after chemotherapy: a prospective longitudinal study in breast cancer patients.

06-12-2006

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Decreased risk of stroke among 10-year survivors of breast cancer.

Trends in genetics : TIG

Knockout mouse models to study Wnt signal transduction.

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation

A validation study of the Dutch version of the Quality of Life-Cancer Survivor (QOL-CS) questionnaire in a group of prostate cancer survivors.

Developmental cell

Prospero acts as a binary switch between self-renewal and differentiation in Drosophila neural stem cells.

European journal of cancer (Oxford, England : 1990)

Development of luciferase tagged brain tumour models in mice for chemotherapy intervention studies.

Cell

Re-evaluating cell-cycle regulation by E2Fs.

Journal of mass spectrometry : JMS

Quantitative analysis of gemcitabine triphosphate in human peripheral blood mononuclear cells using weak anion-exchange liquid chromatography coupled with tandem mass spectrometry.

Cell cycle (Georgetown, Tex.)

Senescence, wound healing and cancer: the PAI-1 connection.

Genome research

Human heterochromatin proteins form large domains containing KRAB-ZNF genes.

British journal of cancer

Molecular subtypes of breast cancer and amplification of topoisomerase II alpha: predictive role in dose intensive adjuvant chemotherapy.

20-11-2006

Cancer research

A causal role for the human tumor antigen preferentially expressed antigen of melanoma in cancer.

15-11-2006

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy

New physiological functions for drug-transporting P-glycoproteins?

10-11-2006

Cancer

Long-term quality of life among Dutch prostate cancer survivors: results of a population-based study.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Relationship between clinical factors and the incidence of toxicity after intra-arterial chemoradiation for head and neck cancer.

Nature genetics

Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture-on-chip (4C).

Clinical cancer research : an official journal of the American Association for Cancer Research

Flat dosing of carboplatin is justified in adult patients with normal renal function.

European journal of cancer (Oxford, England : 1990)

Better quality of life among 10-15 year survivors of Hodgkin's lymphoma compared to 5-9 year survivors: a population-based study.

European journal of cancer (Oxford, England : 1990)

Elderly patients with rectal cancer have a higher risk of treatment-related complications and a poorer prognosis than younger patients: a population-based study.

Cancer cell

Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis.

European journal of cancer (Oxford, England : 1990)

Translation and validation of the SF-36 Health Survey for use among Turkish and Moroccan ethnic minority cancer patients in The Netherlands.

Nature reviews. Cancer

Polycomb silencers control cell fate, development and cancer.