Publications

The Journal of clinical investigation

Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer.

Psycho-oncology

Self-reported cognitive functioning in postmenopausal breast cancer patients before and during endocrine treatment: findings from the neuropsychological TEAM side-study.

Cancer

Germline polymorphisms in patients with advanced nonsmall cell lung cancer receiving first-line platinum-gemcitabine chemotherapy: a prospective clinical study.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Irradiation induced modest changes in murine cardiac function despite progressive structural damage to the myocardium and microvasculature.

Cell

The poly(A)-binding protein nuclear 1 suppresses alternative cleavage and polyadenylation sites.

27-04-2012

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Development and validation of LC-MS/MS assays for the quantification of bendamustine and its metabolites in human plasma and urine.

15-04-2012

Cell cycle (Georgetown, Tex.)

Posttranslational control of telomere maintenance and the telomere damage response.

15-04-2012

The oncologist

Lapatinib for advanced or metastatic breast cancer.

06-04-2012

The Journal of pharmacology and experimental therapeutics

P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) restrict brain accumulation of the active sunitinib metabolite N-desethyl sunitinib.

Molecular biology of the cell

Phosphorylation of threonine 1736 in the C-terminal tail of integrin β4 contributes to hemidesmosome disassembly.

Acta crystallographica. Section D, Biological crystallography

PDB_REDO: constructive validation, more than just looking for errors.

Investigational new drugs

Restricted brain penetration of the tyrosine kinase inhibitor erlotinib due to the drug transporters P-gp and BCRP.

Breast cancer research and treatment

Prediction of BRCA2-association in hereditary breast carcinomas using array-CGH.

Acta oncologica (Stockholm, Sweden)

Scalp cooling for hair preservation and associated characteristics in 1411 chemotherapy patients - results of the Dutch Scalp Cooling Registry.

General hospital psychiatry

Type D personality is associated with increased comorbidity burden and health care utilization among 3080 cancer survivors.

31-03-2012

Advances in immunology

Behavior and function of tissue-resident memory T cells.

28-03-2012

International journal of radiation oncology, biology, physics

Image-guided radiotherapy for left-sided breast cancer patients: geometrical uncertainty of the heart.

15-03-2012

BMC medical informatics and decision making

A review on the relation between simulation and improvement in hospitals.

14-03-2012

Nat Med: Nature medicine

Chemotherapy response of spontaneous mammary tumors is independent of the adaptive immune system

06-03-2012

Drug Resist Updates: reviews and commentaries in antimicrobial and anticancer chemotherapy

A rapidly growing number of therapeutics targeting tumor cell-intrinsic and -extrinsic processes is under development for individualized treatment of cancer patients

Current opinion in urology

Fluorescence guidance in urologic surgery.

Journal of clinical pharmacology

From mouse to man: predictions of human pharmacokinetics of orally administered docetaxel from preclinical studies.

Nucleus (Austin, Tex.)

Hox in space: gene cluster regulation linked to folding of chromatin.

International journal of radiation oncology, biology, physics

Quantification of the variability of diaphragm motion and implications for treatment margin construction.

Nucleus (Austin, Tex.)

Fusing telomeres with RNF8.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Repeat CT assessed CTV variation and PTV margins for short- and long-course pre-operative RT of rectal cancer.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Development and validation of LC-MS/MS assays for the quantification of E7080 and metabolites in various human biological matrices.

European journal of immunology

Reduced tumor-antigen density leads to PD-1/PD-L1-mediated impairment of partially exhausted CD8⁺ T cells.

Future oncology (London, England)

Optical spectroscopy: current advances and future applications in cancer diagnostics and therapy.

Mol Cell Proteomics: Molecular & cellular proteomics: MCP

Proteomics of mouse BRCA1-deficient mammary tumors identifies DNA repair proteins with potential diagnostic and prognostic value in human breast cancer

24-02-2012

Nature

Deleted in colorectal carcinoma suppresses metastasis in p53-deficient mammary tumours.

22-02-2012

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy

Drug resistance in the mouse cancer clinic.

18-02-2012

Breast cancer research and treatment

Neoadjuvant chemotherapy in ER+ HER2- breast cancer: response prediction based on immunohistochemical and molecular characteristics.

Trends in pharmacological sciences

Functions of OATP1A and 1B transporters in vivo: insights from mouse models.

Epigenomics

Crosstalk between aging and the epigenome.

The Journal of clinical investigation

Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver.

Journal of clinical pharmacology

Model-based evaluation of similarity in pharmacokinetics of two formulations of the blood-derived plasma product c1 esterase inhibitor.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

Integration of a smoking cessation program in the treatment protocol for patients with head and neck and lung cancer.

Breast cancer research and treatment

Deoxycytidine kinase is overexpressed in poor outcome breast cancer and determines responsiveness to nucleoside analogs.

Lung cancer (Amsterdam, Netherlands)

Circulating tumor cell detection in advanced non-small cell lung cancer patients by multi-marker QPCR analysis.

Current opinion in genetics & development

Using genetically engineered mouse models to validate candidate cancer genes and test new therapeutic approaches.

Drug metabolism and disposition: the biological fate of chemicals

Mass balance study of [¹⁴C]eribulin in patients with advanced solid tumors.