Publications

Annals of oncology : official journal of the European Society for Medical Oncology

Radiofrequency ablation combined with systemic treatment versus systemic treatment alone in patients with non-resectable colorectal liver metastases: a randomized EORTC Intergroup phase II study (EORTC 40004).

Clinical cancer research : an official journal of the American Association for Cancer Research

Alternative cleavage and polyadenylation during colorectal cancer development.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy

Understanding resistance to targeted cancer drugs through loss of function genetic screens.

Nature methods

Robust 4C-seq data analysis to screen for regulatory DNA interactions.

Bioinformatics (Oxford, England)

A regression model for estimating DNA copy number applied to capture sequencing data.

15-09-2012

Cell

RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling.

14-09-2012

The EMBO journal

An N-terminal acidic region of Sgs1 interacts with Rpa70 and recruits Rad53 kinase to stalled forks.

12-09-2012

Cancer cell

Tumor type-dependent function of the par3 polarity protein in skin tumorigenesis.

11-09-2012

Current biology : CB

Distinct roles of talin and kindlin in regulating integrin α5β1 function and trafficking.

11-09-2012

BMJ (Clinical research ed.)

Exposure to diagnostic radiation and risk of breast cancer among carriers of BRCA1/2 mutations: retrospective cohort study (GENE-RAD-RISK).

06-09-2012

Molecular pharmaceutics

Organic anion-transporting polypeptides 1a/1b control the hepatic uptake of pravastatin in mice.

04-09-2012

Patient education and counseling

Endometrial cancer survivors are unsatisfied with received information about diagnosis, treatment and follow-up: a study from the population-based PROFILES registry.

Annals of oncology : official journal of the European Society for Medical Oncology

Clinical correlates of 'BRCAness' in triple-negative breast cancer of patients receiving adjuvant chemotherapy.

Journal of gastroenterology

Excess weight among colorectal cancer survivors: target for intervention.

The American journal of pathology

Targeting BRAFV600E in an inducible murine model of melanoma.

Journal of cell science

The emerging role of Polycomb repressors in the response to DNA damage.

Nature reviews. Clinical oncology

Can predictive biomarkers in breast cancer guide adjuvant endocrine therapy?

Nature reviews. Cancer

The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance.

Journal of cellular and molecular medicine

Identification of F-box only protein 7 as a negative regulator of NF-kappaB signalling.

Cancer causes & control : CCC

Most colorectal cancer survivors live a large proportion of their remaining life in good health.

The AAPS journal

Performance of methods for handling missing categorical covariate data in population pharmacokinetic analyses.

Familial cancer

Familial gastric cancer: guidelines for diagnosis, treatment and periodic surveillance.

European journal of cancer (Oxford, England : 1990)

Socio-economic implications of cancer survivorship: results from the PROFILES registry.

Cell

Glucosylated hydroxymethyluracil, DNA base J, prevents transcriptional readthrough in Leishmania.

31-08-2012

Methods in enzymology

4C technology: protocols and data analysis.

30-08-2012

Sub-cellular biochemistry

Cdt1 and geminin in DNA replication initiation.

25-08-2012

Oncogene

Targeting the epigenome for treatment of cancer.

23-08-2012

BMC research notes

Scenario drafting to anticipate future developments in technology assessment.

16-08-2012

Journal of the American Chemical Society

Binding of the J-binding protein to DNA containing glucosylated hmU (base J) or 5-hmC: evidence for a rapid conformational change upon DNA binding.

15-08-2012

Cell death & disease

Bcl-2 is a better ABT-737 target than Bcl-xL or Bcl-w and only Noxa overcomes resistance mediated by Mcl-1, Bfl-1, or Bcl-B.

09-08-2012

BMC health services research

Exploring improvements in patient logistics in Dutch hospitals with a survey.

Cytometry. Part A : the journal of the International Society for Analytical Cytology

Validation of a multiparameter flow cytometry method for the determination of phosphorylated extracellular-signal-regulated kinase and DNA in circulating tumor cells.

Annals of oncology : official journal of the European Society for Medical Oncology

The Dutch Childhood Oncology Group guideline for follow-up of asymptomatic cardiac dysfunction in childhood cancer survivors.

Investigational new drugs

Two-stage model-based design of cancer phase I dose escalation trials: evaluation using the phase I program of barasertib (AZD1152).

Cancer prevention research (Philadelphia, Pa.)

Lack of ABCG2 shortens latency of BRCA1-deficient mammary tumors and this is not affected by genistein or resveratrol.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Impact of negative margin width on local recurrence in breast conserving therapy.

Journal of cancer research and clinical oncology

Chemotherapy as primary treatment for brain metastases from breast cancer: analysis of 115 one-year survivors.

Breast (Edinburgh, Scotland)

Axillary and systemic treatment of patients with breast cancer and micrometastatic disease or isolated tumor cells in the sentinel lymph node.

Oncoimmunology

Selective BRAF inhibition decreases tumor-resident lymphocyte frequencies in a mouse model of human melanoma.

British journal of clinical pharmacology

Model-based treatment optimization of a novel VEGFR inhibitor.

Investigational new drugs

Phase I and pharmacokinetic study of capecitabine and the oral mTOR inhibitor everolimus in patients with advanced solid malignancies.

Diabetologia

Disease-specific mortality among stage I-III colorectal cancer patients with diabetes: a large population-based analysis.

PLoS genetics

A key role for Chd1 in histone H3 dynamics at the 3' ends of long genes in yeast.

19-07-2012

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Determination of NVP-BEZ235, a dual PI3K and mTOR inhibitor, in human and mouse plasma and in mouse tissue homogenates by reversed-phase high-performance liquid chromatography with fluorescence detection.

15-07-2012

The Journal of biological chemistry

Structural characterization of binding mode of smoking cessation drugs to nicotinic acetylcholine receptors through study of ligand complexes with acetylcholine-binding protein.

06-07-2012

Head & neck

Five-year quality of life results of the randomized clinical phase III (RADPLAT) trial, comparing concomitant intra-arterial versus intravenous chemoradiotherapy in locally advanced head and neck cancer.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Pre-treatment imaging and pathology characteristics of invasive breast cancers of limited extent: potential relevance for MRI-guided localized therapy.

Oncoimmunology

TIL therapy broadens the tumor-reactive CD8(+) T cell compartment in melanoma patients.

European journal of nuclear medicine and molecular imaging

Concomitant radio- and fluorescence-guided sentinel lymph node biopsy in squamous cell carcinoma of the oral cavity using ICG-(99m)Tc-nanocolloid.