Publications

Investigational new drugs

Restricted brain penetration of the tyrosine kinase inhibitor erlotinib due to the drug transporters P-gp and BCRP.

Breast cancer research and treatment

Prediction of BRCA2-association in hereditary breast carcinomas using array-CGH.

Acta oncologica (Stockholm, Sweden)

Scalp cooling for hair preservation and associated characteristics in 1411 chemotherapy patients - results of the Dutch Scalp Cooling Registry.

General hospital psychiatry

Type D personality is associated with increased comorbidity burden and health care utilization among 3080 cancer survivors.

31-03-2012

Advances in immunology

Behavior and function of tissue-resident memory T cells.

28-03-2012

International journal of radiation oncology, biology, physics

Image-guided radiotherapy for left-sided breast cancer patients: geometrical uncertainty of the heart.

15-03-2012

BMC medical informatics and decision making

A review on the relation between simulation and improvement in hospitals.

14-03-2012

Nat Med: Nature medicine

Chemotherapy response of spontaneous mammary tumors is independent of the adaptive immune system

06-03-2012

Drug Resist Updates: reviews and commentaries in antimicrobial and anticancer chemotherapy

A rapidly growing number of therapeutics targeting tumor cell-intrinsic and -extrinsic processes is under development for individualized treatment of cancer patients

Current opinion in urology

Fluorescence guidance in urologic surgery.

Journal of clinical pharmacology

From mouse to man: predictions of human pharmacokinetics of orally administered docetaxel from preclinical studies.

Nucleus (Austin, Tex.)

Hox in space: gene cluster regulation linked to folding of chromatin.

International journal of radiation oncology, biology, physics

Quantification of the variability of diaphragm motion and implications for treatment margin construction.

Nucleus (Austin, Tex.)

Fusing telomeres with RNF8.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Repeat CT assessed CTV variation and PTV margins for short- and long-course pre-operative RT of rectal cancer.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Development and validation of LC-MS/MS assays for the quantification of E7080 and metabolites in various human biological matrices.

European journal of immunology

Reduced tumor-antigen density leads to PD-1/PD-L1-mediated impairment of partially exhausted CD8⁺ T cells.

Future oncology (London, England)

Optical spectroscopy: current advances and future applications in cancer diagnostics and therapy.

Mol Cell Proteomics: Molecular & cellular proteomics: MCP

Proteomics of mouse BRCA1-deficient mammary tumors identifies DNA repair proteins with potential diagnostic and prognostic value in human breast cancer

24-02-2012

Nature

Deleted in colorectal carcinoma suppresses metastasis in p53-deficient mammary tumours.

22-02-2012

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy

Drug resistance in the mouse cancer clinic.

18-02-2012

Breast cancer research and treatment

Neoadjuvant chemotherapy in ER+ HER2- breast cancer: response prediction based on immunohistochemical and molecular characteristics.

Trends in pharmacological sciences

Functions of OATP1A and 1B transporters in vivo: insights from mouse models.

Epigenomics

Crosstalk between aging and the epigenome.

The Journal of clinical investigation

Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver.

Journal of clinical pharmacology

Model-based evaluation of similarity in pharmacokinetics of two formulations of the blood-derived plasma product c1 esterase inhibitor.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

Integration of a smoking cessation program in the treatment protocol for patients with head and neck and lung cancer.

Breast cancer research and treatment

Deoxycytidine kinase is overexpressed in poor outcome breast cancer and determines responsiveness to nucleoside analogs.

Lung cancer (Amsterdam, Netherlands)

Circulating tumor cell detection in advanced non-small cell lung cancer patients by multi-marker QPCR analysis.

Current opinion in genetics & development

Using genetically engineered mouse models to validate candidate cancer genes and test new therapeutic approaches.

Drug metabolism and disposition: the biological fate of chemicals

Mass balance study of [¹⁴C]eribulin in patients with advanced solid tumors.

Nature

Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR.

26-01-2012

Journal of cell science

Dynamics within tetraspanin pairs affect MHC class II expression.

15-01-2012

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Ipilimumab-induced sarcoidosis in a patient with metastatic melanoma undergoing complete remission.

10-01-2012

Medical physics

In aqua vivo EPID dosimetry.

The Journal of pathology

Fancf-deficient mice are prone to develop ovarian tumours.

Results in immunology

Testing for HLA/peptide tetramer-binding to the T cell receptor complex on human T lymphocytes.

Pharmacoepidemiology and drug safety

Record linkage for pharmacoepidemiological studies in cancer patients.

Cell cycle (Georgetown, Tex.)

News about old histones: a role for histone age in controlling the epigenome.

Cellular and molecular life sciences : CMLS

Genomic instability in breast and ovarian cancers: translation into clinical predictive biomarkers.

Biomaterials

Targeted non-covalent self-assembled nanoparticles based on human serum albumin.

Cancer chemotherapy and pharmacology

Gene polymorphisms, pharmacokinetics, and hematological toxicity in advanced non-small-cell lung cancer patients receiving cisplatin/gemcitabine.

Genes & development

A decade of 3C technologies: insights into nuclear organization.

The Journal of clinical investigation

Blood pressure influences end-stage renal disease of Cd151 knockout mice.

International journal of cancer

Brain accumulation of sunitinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by oral elacridar and sunitinib coadministration.

Journal of clinical laboratory analysis

Search for breast cancer biomarkers in fractionated serum samples by protein profiling with SELDI-TOF MS.

Journal of affective disorders

Type D (distressed) personality is associated with poor quality of life and mental health among 3080 cancer survivors.

Breast cancer research and treatment

Head-to-head comparison of the 70-gene signature versus the 21-gene assay: cost-effectiveness and the effect of compliance.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Genetic variants in TGFβ-1 and PAI-1 as possible risk factors for cardiovascular disease after radiotherapy for breast cancer.