Publications

The Journal of investigative dermatology

T-cell receptor gene therapy: critical parameters for clinical success.

Annals of oncology : official journal of the European Society for Medical Oncology

Additional value and potential use of the 70-gene prognosis signature in node-negative breast cancer in daily clinical practice.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

Review: incidence and clinical significance of Bevacizumab-related non-surgical and surgical serious adverse events in metastatic colorectal cancer.

Gut

Synergistic tumour suppressor activity of E-cadherin and p53 in a conditional mouse model for metastatic diffuse-type gastric cancer

24-08-2011

Nature cell biology

DNA-damage response and repair activities at uncapped telomeres depend on RNF8.

21-08-2011

Oncogene

Bid can mediate a pro-apoptotic response to etoposide and ionizing radiation without cleavage in its unstructured loop and in the absence of p53.

18-08-2011

Chembiochem : a European journal of chemical biology

Peptide-functionalized luminescent iridium complexes for lifetime imaging of CXCR4 expression.

16-08-2011

Human molecular genetics

Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium.

15-08-2011

Nature reviews. Cancer

MicroRNA regulation by RNA-binding proteins and its implications for cancer.

05-08-2011

Journal of structural biology

Investigating a macromolecular complex: the toolkit of methods.

Human brain mapping

Cerebral hyporesponsiveness and cognitive impairment 10 years after chemotherapy for breast cancer.

Breast cancer research and treatment

Unfavourable pattern of metastases in M0 breast cancer patients during 1978-2008: a population-based analysis of the Munich Cancer Registry.

Translational oncology

Immunohistochemical detection of the CXCR4 expression in tumor tissue using the fluorescent peptide antagonist Ac-TZ14011-FITC.

Drug metabolism and disposition: the biological fate of chemicals

Impact of abcc2 [multidrug resistance-associated protein (MRP) 2], abcc3 (MRP3), and abcg2 (breast cancer resistance protein) on the oral pharmacokinetics of methotrexate and its main metabolite 7-hydroxymethotrexate.

Cancer discovery

Functional subtyping of breast cancer.

Nucleic acids research

Computational identification of insertional mutagenesis targets for cancer gene discovery.

European journal of cancer (Oxford, England : 1990)

Impact of chemotherapy on health status and symptom burden of colon cancer survivors: a population-based study.

Current gene therapy

Prospects and limitations of T cell receptor gene therapy.

Journal of structural biology

Enabling high-throughput ligation-independent cloning and protein expression for the family of ubiquitin specific proteases.

International journal of cancer

Preclinical development of highly effective and safe DNA vaccines directed against HPV 16 E6 and E7.

15-07-2011

Journal of medicinal chemistry

Structure-based design of novel boronic acid-based inhibitors of autotaxin.

14-07-2011

J Clin Invest: The Journal of clinical investigation

Cytosolic p120-catenin regulates growth of metastatic lobular carcinoma through Rock1-mediated anoikis resistance

11-07-2011

Annals of oncology : official journal of the European Society for Medical Oncology

An aCGH classifier derived from BRCA1-mutated breast cancer and benefit of high-dose platinum-based chemotherapy in HER2-negative breast cancer patients.

The British journal of surgery

Impact of concentration of oesophageal and gastric cardia cancer surgery on long-term population-based survival.

Genes & development

The inactive X chromosome adopts a unique three-dimensional conformation that is dependent on Xist RNA.

Nucleic acids research

The structural basis for recognition of base J containing DNA by a novel DNA binding domain in JBP1.

Clinical pharmacology and therapeutics

Population pharmacokinetic-pharmacodynamic analysis of trastuzumab-associated cardiotoxicity.

Breast cancer research and treatment

Improved survival of patients with primary distant metastatic breast cancer in the period of 1995-2008. A nationwide population-based study in the Netherlands.

Nature cell biology

Variegated gene expression caused by cell-specific long-range DNA interactions.

26-06-2011

Cancer cell

Cell of origin of small cell lung cancer: inactivation of Trp53 and Rb1 in distinct cell types of adult mouse lung.

14-06-2011

The oncologist

Part 4: pharmacogenetic variability in anticancer pharmacodynamic drug effects.

11-06-2011

The oncologist

Part 3: Pharmacogenetic variability in phase II anticancer drug metabolism.

11-06-2011

British journal of cancer

A multimarker QPCR-based platform for the detection of circulating tumour cells in patients with early-stage breast cancer.

07-06-2011

The oncologist

Part 2: pharmacogenetic variability in drug transport and phase I anticancer drug metabolism.

03-06-2011

The oncologist

Part 1: background, methodology, and clinical adoption of pharmacogenetics.

03-06-2011

The oncologist

Trastuzumab.

03-06-2011

PLoS biology

Patterns and mechanisms of ancestral histone protein inheritance in budding yeast.

Genetics in medicine : official journal of the American College of Medical Genetics

Compliance with periodic surveillance for Von-Hippel-Lindau disease.

The AAPS journal

Evaluation of α2-integrin expression as a biomarker for tumor growth inhibition for the investigational integrin inhibitor E7820 in preclinical and clinical studies.

International journal of radiation oncology, biology, physics

Residual seminal vesicle displacement in marker-based image-guided radiotherapy for prostate cancer and the impact on margin design.

Climacteric : the journal of the International Menopause Society

Characteristics of breast cancer patients who experience menopausal transition due to treatment.

The Journal of pharmacology and experimental therapeutics

P-glycoprotein (ABCB1) transports the primary active tamoxifen metabolites endoxifen and 4-hydroxytamoxifen and restricts their brain penetration.

Pharmacological reviews

A critical analysis of the interplay between cytochrome P450 3A and P-glycoprotein: recent insights from knockout and transgenic mice.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

Quality of life and consequences for daily life of familial adenomatous polyposis (FAP) family members.

Psycho-oncology

Distress in partners of individuals diagnosed with or at high risk of developing tumors due to rare hereditary cancer syndromes.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Development and validation of a quantitative assay for the determination of tamoxifen and its five main phase I metabolites in human serum using liquid chromatography coupled with tandem mass spectrometry.

Journal of pharmaceutical and biomedical analysis

Investigational study of tamoxifen phase I metabolites using chromatographic and spectroscopic analytical techniques.

Current oncology reports

Non-clear cell renal cell carcinoma: how new biological insight may lead to new therapeutic modalities.