Publications

Journal of pharmaceutical sciences

The functional role of P-glycoprotein in the blood-brain barrier.

01-08-1997

Seminars in oncology

Hepatic metabolism of paclitaxel and its impact in patients with altered hepatic function.

01-08-1997

Annals of oncology : official journal of the European Society for Medical Oncology

Successful intraperitoneal suramin treatment of peritoneal mesothelioma.

01-08-1997

Acta crystallographica. Section D, Biological crystallography

wARP: improvement and extension of crystallographic phases by weighted averaging of multiple-refined dummy atomic models.

01-07-1997

Biochemical and biophysical research communications

The unique cytoplasmic domain of the human integrin variant beta4E is produced by partial retention of intronic sequences.

27-06-1997

FEBS letters

Communication between the extracellular environment, cytoplasmic signalling cascades and the nuclear cell-cycle machinery.

23-06-1997

Trends in genetics : TIG

Genetic dissection of the function of mammalian P-glycoproteins.

01-06-1997

Seminars in cancer biology

The physiological function of drug-transporting P-glycoproteins.

01-06-1997

Oncogene

Bcl-2 reduces lymphomagenesis in deltaV-TCRbeta transgenic mice.

29-05-1997

The Biochemical journal

Identification of the cleavage sites in the alpha6A integrin subunit: structural requirements for cleavage and functional analysis of the uncleaved alpha6Abeta1 integrin.

15-05-1997

Nucleic acids research

Cre-mediated somatic site-specific recombination in mice.

01-05-1997

Medical care

The use of significant others as proxy raters of the quality of life of patients with brain cancer.

01-05-1997

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Phase I and pharmacologic study of the combination paclitaxel and carboplatin as first-line chemotherapy in stage III and IV ovarian cancer.

01-05-1997

Proceedings of the National Academy of Sciences of the United States of America

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins.

15-04-1997

Annals of oncology : official journal of the European Society for Medical Oncology

Phase II study of the combination carboplatin and paclitaxel in patients with ovarian cancer.

01-04-1997

Laboratory investigation; a journal of technical methods and pathology

The A and B variants of the alpha 3 integrin subunit: tissue distribution and functional characterization.

01-04-1997

Molecular biology of the cell

Integrin alpha 6 beta 4 forms a complex with the cytoskeletal protein HD1 and induces its redistribution in transfected COS-7 cells.

01-04-1997

The Journal of cell biology

The localization of bullous pemphigoid antigen 180 (BP180) in hemidesmosomes is mediated by its cytoplasmic domain and seems to be regulated by the beta4 integrin subunit.

24-03-1997

Proceedings of the National Academy of Sciences of the United States of America

Structural basis for dual excitation and photoisomerization of the Aequorea victoria green fluorescent protein.

18-03-1997

Oncogene

Overexpression of the FosB2 gene in thymocytes causes aberrant development of T cells and thymic epithelial cells.

06-03-1997

Proceedings of the National Academy of Sciences of the United States of America

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine.

04-03-1997

Behring Institute Mitteilungen

Mechanisms of antigenic variation in African trypanosomes.

01-03-1997

Cancer treatment reviews

Alternative formulations of paclitaxel.

01-03-1997

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Value of caregiver ratings in evaluating the quality of life of patients with cancer.

01-03-1997

PDA journal of pharmaceutical science and technology

Pharmaceutical development of a parenteral formulation of the investigational anticancer drug clanfenur.

01-03-1997

Cancer treatment reviews

Growth factors in human ovarian cancer.

01-03-1997

Cell

CDK-independent activation of estrogen receptor by cyclin D1.

07-02-1997

The EMBO journal

Activation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomas.

03-02-1997

Seminars in oncology

Carboplatin and paclitaxel in patients with advanced ovarian cancer: a dose-finding study.

01-02-1997

Genes & development

Identification of Bmi1-interacting proteins as constituents of a multimeric mammalian polycomb complex.

15-01-1997

Cancer chemotherapy and pharmacology

The vascular compartment hampers accurate determination of teniposide penetration into brain tumor tissue.

01-01-1997

British journal of cancer

Phase I and pharmacological study of sequential intravenous topotecan and oral etoposide.

01-01-1997

British journal of cancer

Enhanced oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833.

01-01-1997

Critical reviews in oncogenesis

The Cbl family of signal transduction molecules.

01-01-1997

Cancer chemotherapy and pharmacology

Isolation and structural confirmation of N-desmethyl topotecan, a metabolite of topotecan.

01-01-1997

Journal of cell science

The subcellular distribution of the high molecular mass protein, HD1, is determined by the cytoplasmic domain of the integrin beta 4 subunit.

01-01-1997

European journal of haematology

Ultrastructural localization of Charcot-Leyden crystal protein in human eosinophils and basophils.

01-01-1997

Journal of virology

Characterization of pal-1, a common proviral insertion site in murine leukemia virus-induced lymphomas of c-myc and Pim-1 transgenic mice.

01-01-1997

Folding & design

Evolution of immunoglobulin-like modules in chitinases: their structural flexibility and functional implications.

01-01-1997

The EMBO journal

Bax alpha perturbs T cell development and affects cell cycle entry of T cells.

16-12-1996

Journal of the National Cancer Institute

Induced abortion and risk for breast cancer: reporting (recall) bias in a Dutch case-control study.

04-12-1996

The Netherlands journal of medicine

Tamoxifen, balancing risks and benefits.

01-12-1996

Genes & development

Degradation of E2F by the ubiquitin-proteasome pathway: regulation by retinoblastoma family proteins and adenovirus transforming proteins.

01-12-1996

Nature genetics

Complex interactions of new quantitative trait loci, Sluc1, Sluc2, Sluc3, and Sluc4, that influence the susceptibility to lung cancer in the mouse.

01-12-1996

The EMBO journal

Homologues of the human multidrug resistance genes MRP and MDR contribute to heavy metal resistance in the soil nematode Caenorhabditis elegans.

15-11-1996

American journal of epidemiology

p53 protein overexpression in relation to risk factors for breast cancer.

15-11-1996

Journal of pharmaceutical sciences

Systematic study on the chemical stability of the prodrug antitumor agent carzelesin (U-80,244).

01-11-1996

The Journal of cell biology

Direct vesicular transport of MHC class II molecules from lysosomal structures to the cell surface.

01-11-1996

Journal of pharmaceutical and biomedical analysis

The impact of column temperature in the high performance liquid chromatographic analysis of topotecan in rat and dog plasma.

01-11-1996

British journal of pharmacology

Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr 1a P-glycoprotein.

01-11-1996