Publications

Advances in experimental medicine and biology

A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors.

19-08-2007

Blood

In vivo p53 response and immune reaction underlie highly effective low-dose radiotherapy in follicular lymphoma.

15-08-2007

International journal of cancer

Increased health care utilization among long-term cancer survivors compared to the average Dutch population: a population-based study.

15-08-2007

Journal of immunology (Baltimore, Md. : 1950)

In vivo antigen stability affects DNA vaccine immunogenicity.

15-08-2007

The EMBO journal

PKA-induced resistance to tamoxifen is associated with an altered orientation of ERalpha towards co-activator SRC-1.

08-08-2007

The EMBO journal

Regulation of the p27(Kip1) tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferation.

08-08-2007

The Journal of experimental medicine

A/T mutagenesis in hypermutated immunoglobulin genes strongly depends on PCNAK164 modification.

06-08-2007

AAPS PharmSciTech

Development of a bladder instillation of the indoloquinone anticancer agent EO-9 using tert-butyl alcohol as lyophilization vehicle.

03-08-2007

Investigational new drugs

Human mass balance study of the novel anticancer agent ixabepilone using accelerator mass spectrometry.

01-08-2007

Clinical cancer research : an official journal of the American Association for Cancer Research

Phase I pharmacokinetic and pharmacodynamic study of the oral protein kinase C beta-inhibitor enzastaurin in combination with gemcitabine and cisplatin in patients with advanced cancer.

01-08-2007

Minerva ginecologica

Effects of hormonal therapy on cognitive functioning in breast cancer patients: a review of the literature.

01-08-2007

The oncologist

Concise review: Clinical relevance of drug drug and herb drug interactions mediated by the ABC transporter ABCB1 (MDR1, P-glycoprotein).

01-08-2007

Clinical cancer research : an official journal of the American Association for Cancer Research

Phase I pharmacokinetic study of the safety and tolerability of lapatinib (GW572016) in combination with oxaliplatin/fluorouracil/leucovorin (FOLFOX4) in patients with solid tumors.

01-08-2007

Breast (Edinburgh, Scotland)

Trends in the prognosis of patients with primary metastatic breast cancer diagnosed between 1975 and 2002.

01-08-2007

International archives of occupational and environmental health

Monitoring of platinum surface contamination in seven Dutch hospital pharmacies using inductively coupled plasma mass spectrometry.

01-08-2007

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

The health-related quality of life of long-term survivors of melanoma treated with isolated limb perfusion.

01-08-2007

Molecular cancer therapeutics

A new class of anticancer alkylphospholipids uses lipid rafts as membrane gateways to induce apoptosis in lymphoma cells.

01-08-2007

Proceedings of the National Academy of Sciences of the United States of America

Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer.

17-07-2007

Proceedings of the National Academy of Sciences of the United States of America

Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer.

17-07-2007

Nucleic acids research

Determinants for DNA target structure selectivity of the human LINE-1 retrotransposon endonuclease.

13-07-2007

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Simultaneous quantification of cyclophosphamide and its active metabolite 4-hydroxycyclophosphamide in human plasma by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (LC-MS/MS).

01-07-2007

Cancer research

Critical role for TrkB kinase function in anoikis suppression, tumorigenesis, and metastasis.

01-07-2007

Biomedical chromatography : BMC

Determination of imatinib mesylate and its main metabolite (CGP74588) in human plasma and murine specimens by ion-pairing reversed-phase high-performance liquid chromatography.

01-07-2007

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Prognostic significance of 99mTc Hynic-rh-annexin V scintigraphy during platinum-based chemotherapy in advanced lung cancer.

20-06-2007

Rapid communications in mass spectrometry : RCM

Validated assay for the simultaneous determination of the anti-cancer agent gemcitabine and its metabolite 2',2'-difluorodeoxyuridine in human plasma by high-performance liquid chromatography with tandem mass spectrometry.

20-06-2007

Cell

All roads lead to IKKepsilon.

15-06-2007

Hereditary cancer in clinical practice

Colorectal cancer in the family: psychosocial distress and social issues in the years following genetic counselling.

15-06-2007

Experimental cell research

Plakins in development and disease.

10-06-2007

The EMBO journal

Noncovalent interaction between Ubc9 and SUMO promotes SUMO chain formation.

06-06-2007

Nature protocols

Detection of in vivo protein-DNA interactions using DamID in mammalian cells.

05-06-2007

The Journal of cell biology

Regulation of connexin43 gap junctional communication by phosphatidylinositol 4,5-bisphosphate.

04-06-2007

Biochimica et biophysica acta

Classifying microRNAs in cancer: the good, the bad and the ugly.

01-06-2007

Clinical cancer research : an official journal of the American Association for Cancer Research

A phase I, randomized, open-label, parallel-cohort, dose-finding study of elacridar (GF120918) and oral topotecan in cancer patients.

01-06-2007

Nature genetics

MMTV insertional mutagenesis identifies genes, gene families and pathways involved in mammary cancer.

01-06-2007

Investigational new drugs

Phase I dose-finding and pharmacokinetic trial of orally administered indibulin (D-24851) to patients with solid tumors.

01-06-2007

American journal of physiology. Cell physiology

Breast cancer resistance protein (Bcrp1/Abcg2) is expressed in the harderian gland and mediates transport of conjugated protoporphyrin IX.

01-06-2007

Gynecologic oncology

Trends in cervical cancer survival in Europe, 1983-1994: a population-based study.

01-06-2007

International journal of radiation oncology, biology, physics

Kilo-voltage cone-beam computed tomography setup measurements for lung cancer patients; first clinical results and comparison with electronic portal-imaging device.

01-06-2007

Journal of molecular biology

The structure of a tandem pair of spectrin repeats of plectin reveals a modular organization of the plakin domain.

18-05-2007

Cancer research

Dominant-negative but not gain-of-function effects of a p53.R270H mutation in mouse epithelium tissue after DNA damage

15-05-2007

Cancer

The safety of breast-conserving therapy in patients with breast cancer aged < or = 40 years.

15-05-2007

Clinical cancer research : an official journal of the American Association for Cancer Research

CYP2C9 and CYP2C19 polymorphic forms are related to increased indisulam exposure and higher risk of severe hematologic toxicity.

15-05-2007

International journal of technology assessment in health care

Methodology of constructive technology assessment in health care.

12-05-2007

Journal of immunotherapy (Hagerstown, Md. : 1997)

Phase I clinical study with multiple peptide vaccines in combination with tetanus toxoid and GM-CSF in advanced-stage HLA-A*0201-positive melanoma patients.

02-05-2007

Blood

Effective graft depletion of MiHAg T-cell specificities and consequences for graft-versus-host disease.

01-05-2007

Cancer chemotherapy and pharmacology

The effect of hydroxyurea on P-glycoprotein/BCRP-mediated transport and CYP3A metabolism of imatinib mesylate.

01-05-2007

Molecular cancer therapeutics

Classification of anti-estrogens according to intramolecular FRET effects on phospho-mutants of estrogen receptor alpha.

01-05-2007

International journal of cancer

Less aggressive treatment and worse overall survival in cancer patients with diabetes: a large population based analysis.

01-05-2007

Medical physics

A fast algorithm for gamma evaluation in 3D.

01-05-2007

Cancer chemotherapy and pharmacology

Metabolism of trabectedin (ET-743, Yondelis) in patients with advanced cancer.

01-05-2007