Publications

Drug development and industrial pharmacy

Development of a lyophilized parenteral pharmaceutical formulation of the investigational polypeptide marine anticancer agent kahalalide F.

01-09-2001

Clinical pharmacokinetics

Population pharmacokinetics of ifosfamide and its dechloroethylated and hydroxylated metabolites in children with malignant disease: a sparse sampling approach.

29-08-2001

PDA journal of pharmaceutical science and technology

In vitro hemolysis and buffer capacity studies with the novel marine anticancer agent kahalalide F and its reconstitution vehicle cremophor EL/ethanol.

17-08-2001

Journal of chromatography. B, Biomedical sciences and applications

Bioanalysis and preliminary pharmacokinetics of the acridonecarboxamide derivative GF120918 in plasma of mice and humans by ion-pairing reversed-phase high-performance liquid chromatography with fluorescence detection.

05-08-2001

Clinical pharmacology and therapeutics

Modulation of the cytochrome P450-mediated metabolism of ifosfamide by ketoconazole and rifampin.

01-08-2001

Anti-cancer drugs

Pharmacokinetics of oral cyclosporin A when co-administered to enhance the oral absorption of paclitaxel.

01-08-2001

Drug metabolism and disposition: the biological fate of chemicals

Influence of dose and infusion duration on pharmacokinetics of ifosfamide and metabolites.

01-07-2001

Cancer chemotherapy and pharmacology

Population pharmacokinetics of ifosfamide and its 2- and 3-dechloroethylated and 4-hydroxylated metabolites in resistant small-cell lung cancer patients.

01-07-2001

Bone marrow transplantation

Phase II study of a multi-course high-dose chemotherapy regimen incorporating cyclophosphamide, thiotepa, and carboplatin in stage IV breast cancer.

01-07-2001

European journal of clinical pharmacology

Pharmacokinetics of oral cyclosporin A when co-administered to enhance the absorption of orally administered docetaxel.

01-07-2001

Journal of chromatography. B, Biomedical sciences and applications

Sensitive gas chromatographic determination of the cyclophosphamide metabolite 2-dechloroethylcyclophosphamide in human plasma.

15-06-2001

Cancer chemotherapy and pharmacology

Successful rescue with leucovorin and thymidine in a patient with high-dose methotrexate induced acute renal failure.

01-06-2001

Journal of pharmacokinetics and pharmacodynamics

A mechanism-based pharmacokinetic model for the cytochrome P450 drug-drug interaction between cyclophosphamide and thioTEPA and the autoinduction of cyclophosphamide.

01-06-2001

Investigational new drugs

Progress in the development of alternative pharmaceutical formulations of taxanes.

01-05-2001

Investigational new drugs

Oral delivery of taxanes.

01-05-2001

European journal of cancer (Oxford, England : 1990)

Extensive cytoreductive surgery followed by intra-operative hyperthermic intraperitoneal chemotherapy with mitomycin-C in patients with peritoneal carcinomatosis of colorectal origin.

01-05-2001

Journal of chromatography. B, Biomedical sciences and applications

Degradation kinetics of aplidine, a new marine antitumoural cyclic peptide, in aqueous solution.

15-04-2001

Anti-cancer drugs

Phase I clinical and pharmacokinetic study of PNU166945, a novel water-soluble polymer-conjugated prodrug of paclitaxel.

01-04-2001

Biopharmaceutics & drug disposition

Distribution of ifosfamide and metabolites between plasma and erythrocytes.

01-04-2001

Cancer chemotherapy and pharmacology

A phase I and pharmacokinetic study of bi-daily dosing of oral paclitaxel in combination with cyclosporin A.

01-04-2001

Anti-cancer drugs

The effect of different doses of cyclosporin A on the systemic exposure of orally administered paclitaxel.

01-04-2001

Molecular pharmacology

P-glycoprotein limits oral availability, brain, and fetal penetration of saquinavir even with high doses of ritonavir.

01-04-2001

Clinical cancer research : an official journal of the American Association for Cancer Research

Circumvention of breast cancer resistance protein (BCRP)-mediated resistance to camptothecins in vitro using non-substrate drugs or the BCRP inhibitor GF120918.

01-04-2001

Anti-cancer drugs

Ras biochemistry and farnesyl transferase inhibitors: a literature survey.

01-03-2001

Annals of the New York Academy of Sciences

Transport of topoisomerase I inhibitors by the breast cancer resistance protein. Potential clinical implications.

24-02-2001

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Coadministration of cyclosporine strongly enhances the oral bioavailability of docetaxel.

15-02-2001

British journal of cancer

Co-administration of GF120918 significantly increases the systemic exposure to oral paclitaxel in cancer patients.

05-01-2001

British journal of clinical pharmacology

Population pharmacokinetics of thioTEPA and its active metabolite TEPA in patients undergoing high-dose chemotherapy.

01-01-2001

Clinical pharmacokinetics

Clinical pharmacokinetics and pharmacodynamics of ifosfamide and its metabolites.

01-01-2001

Clinical cancer research : an official journal of the American Association for Cancer Research

Pharmacokinetics and pharmacodynamics of the novel marine-derived anticancer agent ecteinascidin 743 in a phase I dose-finding study.

01-12-2000

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Modulation of oral bioavailability of anticancer drugs: from mouse to man.

01-12-2000

Anti-cancer drugs

Metabolism and excretion of paclitaxel after oral administration in combination with cyclosporin A and after i.v. administration.

01-11-2000

Anti-cancer drugs

Pharmaceutical development of anticancer agents derived from marine sources.

01-11-2000

Clinical cancer research : an official journal of the American Association for Cancer Research

Increased oral bioavailability of paclitaxel by GF120918 in mice through selective modulation of P-glycoprotein.

01-11-2000

Clinical pharmacokinetics

Pharmacokinetically guided administration of chemotherapeutic agents.

01-11-2000

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

Extensive cytoreductive surgery combined with intra-operative intraperitoneal perfusion with cisplatin under hyperthermic conditions (OVHIPEC) in patients with recurrent ovarian cancer: a feasibility pilot.

01-11-2000

Journal of the National Cancer Institute

Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan.

18-10-2000

Therapeutic drug monitoring

Determination of ifosfamide, 2- and 3-dechloroethyifosfamide using gas chromatography with nitrogen-phosphorus or mass spectrometry detection.

01-10-2000

Anti-cancer drugs

Cremophor EL pharmacokinetics in a phase I study of paclitaxel (Taxol) and carboplatin in non-small cell lung cancer patients.

01-10-2000

Cancer chemotherapy and pharmacology

Reduction of cyclophosphamide bioactivation by thioTEPA: critical sequence-dependency in high-dose chemotherapy regimens.

06-09-2000

Journal of chromatography. B, Biomedical sciences and applications

Simple and selective determination of the cyclophosphamide metabolite phosphoramide mustard in human plasma using high-performance liquid chromatography.

18-08-2000

The Annals of pharmacotherapy

Cyclosporine-induced anaphylaxis.

06-08-2000

PDA journal of pharmaceutical science and technology

Pharmaceutical development of a parenteral lyophilized formulation of the novel antitumor agent aplidine.

06-08-2000

Anti-cancer drugs

The clinical pharmacology of alkylating agents in high-dose chemotherapy.

01-08-2000

British journal of cancer

Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export.

01-08-2000

Investigational new drugs

The oral route for the administration of cytotoxic drugs: strategies to increase the efficiency and consistency of drug delivery.

01-08-2000

Cancer chemotherapy and pharmacology

Feasibility and pharmacokinetics of intraperitoneal suramin in advanced malignancy.

27-07-2000

Proceedings of the National Academy of Sciences of the United States of America

Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs.

20-06-2000

Clinical pharmacology and therapeutics

Validation of techniques for the prediction of carboplatin exposure: application of Bayesian methods.

01-06-2000

British journal of clinical pharmacology

Evaluation of the autoinduction of ifosfamide metabolism by a population pharmacokinetic approach using NONMEM.

01-06-2000