Publications

Journal of mass spectrometry : JMS

Quantitative analysis of ES-285, an investigational marine anticancer drug, in human, mouse, rat, and dog plasma using coupled liquid chromatography and tandem mass spectrometry.

01-05-2003

Investigational new drugs

Pharmacokinetic-pharmacodynamic guided trial design in oncology.

01-05-2003

Anti-cancer drugs

Metabolism of paclitaxel in mice.

01-03-2003

Journal of pharmaceutical and biomedical analysis

Development of a LC method for pharmaceutical quality control of the antimetastatic ruthenium complex NAMI-A.

26-02-2003

Therapeutic drug monitoring

High-performance liquid chromatographic analysis of the anticancer drug irinotecan (CPT-11) and its active metabolite SN-38 in human plasma.

01-02-2003

Annals of oncology : official journal of the European Society for Medical Oncology

Weekly oral paclitaxel as first-line treatment in patients with advanced gastric cancer.

01-02-2003

The Journal of pharmacology and experimental therapeutics

Assessing safety and efficacy of directed P-glycoprotein inhibition to improve the pharmacokinetic properties of saquinavir coadministered with ritonavir.

01-02-2003

Biochemical pharmacology

DNA repair mechanisms involved in gemcitabine cytotoxicity and in the interaction between gemcitabine and cisplatin.

15-01-2003

The oncologist

Improvement of oral drug treatment by temporary inhibition of drug transporters and/or cytochrome P450 in the gastrointestinal tract and liver: an overview.

20-12-2002

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Phase II and pharmacologic study of weekly oral paclitaxel plus cyclosporine in patients with advanced non-small-cell lung cancer.

01-12-2002

Cancer treatment reviews

DNA-based drug interactions of cisplatin.

01-12-2002

Cancer chemotherapy and pharmacology

Development of an optimal pharmacokinetic sampling schedule for rubitecan administered orally in a daily times five schedule.

01-12-2002

Molecular pharmacology

Thiopurine metabolism and identification of the thiopurine metabolites transported by MRP4 and MRP5 overexpressed in human embryonic kidney cells.

01-12-2002

Proceedings of the National Academy of Sciences of the United States of America

The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria.

26-11-2002

AIDS (London, England)

Multidrug resistance protein 2 (MRP2) transports HIV protease inhibitors, and transport can be enhanced by other drugs.

22-11-2002

Journal of pharmaceutical and biomedical analysis

Photostability profiles of the experimental antimetastatic ruthenium complex NAMI-A.

07-11-2002

International journal of pharmaceutics

Pharmaceutical development of a parenteral lyophilized formulation of the antimetastatic ruthenium complex NAMI-A.

06-11-2002

International journal of pharmaceutics

A kinetic study of the chemical stability of the antimetastatic ruthenium complex NAMI-A.

06-11-2002

British journal of clinical pharmacology

Development and validation of limited sampling strategies for prediction of the systemic exposure to the novel anticancer agent E7070 (N-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide).

01-11-2002

Anti-cancer drugs

E7070: a novel synthetic sulfonamide targeting the cell cycle progression for the treatment of cancer.

01-11-2002

Bone marrow transplantation

Relationship between irreversible alopecia and exposure to cyclophosphamide, thiotepa and carboplatin (CTC) in high-dose chemotherapy.

01-11-2002

Cancer research

Low systemic exposure of oral docetaxel in mice resulting from extensive first-pass metabolism is boosted by ritonavir.

01-11-2002

Anti-cancer drugs

Stability and compatibility of the investigational polymer-conjugated platinum anticancer agent AP 5280 in infusion systems and its hemolytic potential.

01-10-2002

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Population pharmacokinetics of the novel anticancer agent E7070 during four phase I studies: model building and validation.

01-10-2002

British journal of cancer

A phase I and pharmacokinetic study of MAG-CPT, a water-soluble polymer conjugate of camptothecin.

09-09-2002

Cancer chemotherapy and pharmacology

Extremely high exposures in an obese patient receiving high-dose cyclophosphamide, thiotepa and carboplatin.

01-09-2002

Anti-cancer drugs

An excretion balance and pharmacokinetic study of the novel anticancer agent E7070 in cancer patients.

01-09-2002

Journal of mass spectrometry : JMS

Quantitative analysis of the novel depsipeptide anticancer drug Kahalalide F in human plasma by high-performance liquid chromatography under basic conditions coupled to electrospray ionization tandem mass spectrometry.

01-09-2002

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Determination of 9-nitrocamptothecin and its metabolite 9-aminocamptothecin in human plasma using high-performance liquid chromatography with ultraviolet and fluorescence detection.

05-08-2002

European journal of cancer (Oxford, England : 1990)

Phase I and pharmacological study of daily oral administration of perifosine (D-21266) in patients with advanced solid tumours.

01-08-2002

Cancer chemotherapy and pharmacology

Urinary and fecal excretion of topotecan in patients with malignant solid tumours.

01-07-2002

Cancer chemotherapy and pharmacology

A population analysis of the pharmacokinetics of Cremophor EL using nonlinear mixed-effect modelling.

01-07-2002

Analytical and bioanalytical chemistry

Determination of total platinum in plasma and plasma ultrafiltrate, from subjects dosed with the platinum-containing N-(2-hydroxypropyl)methacrylamide copolymer AP5280, by use of graphite-furnace Zeeman atomic-absorption spectrometry.

01-07-2002

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Increased oral bioavailability of topotecan in combination with the breast cancer resistance protein and P-glycoprotein inhibitor GF120918.

01-07-2002

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Phase I clinical and pharmacologic study of chronic oral administration of the farnesyl protein transferase inhibitor R115777 in advanced cancer.

01-06-2002

European journal of drug metabolism and pharmacokinetics

Evaluation of the bioequivalence of tablets and capsules containing the novel anticancer agent R115777 (Zarnestra) in patients with advanced solid tumors.

09-05-2002

Anti-cancer drugs

Clinical pharmacology of the novel marine-derived anticancer agent Ecteinascidin 743 administered as a 1- and 3-h infusion in a phase I study.

01-04-2002

Cancer chemotherapy and pharmacology

Population pharmacokinetics of the novel anticancer agent KRN7000.

01-04-2002

Annals of oncology : official journal of the European Society for Medical Oncology

Relationship between exposure and toxicity in high-dose chemotherapy with cyclophosphamide, thiotepa and carboplatin.

01-03-2002

Cancer chemotherapy and pharmacology

Phase I and pharmacokinetic study of SPI-77, a liposomal encapsulated dosage form of cisplatin.

01-03-2002

Cancer chemotherapy and pharmacology

Entrapment by Cremophor EL decreases the absorption of paclitaxel from the gut.

01-02-2002

Anti-cancer drugs

Topoisomerase I levels in white blood cells of patients with ovarian cancer treated with paclitaxel-cisplatin-topotecan in a phase I study.

01-01-2002

The Journal of biological chemistry

Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3).

07-12-2001

Cancer chemotherapy and pharmacology

A comparison of limited sampling strategies for prediction of Ecteinascidin 743 clearance when administered as a 24-h infusion.

01-12-2001

Therapeutic drug monitoring

Validation of a therapeutic drug monitoring strategy for thiotepa in a high-dose chemotherapy regimen.

01-12-2001

British journal of cancer

The co-solvent Cremophor EL limits absorption of orally administered paclitaxel in cancer patients.

16-11-2001

Journal of chromatography. B, Biomedical sciences and applications

High-performance liquid chromatographic analysis for the determination of a novel polymer-bound camptothecin derivative (MAG-camptothecin) and free camptothecin in human plasma.

05-11-2001

Journal of chromatography. B, Biomedical sciences and applications

Determination of cyclosporin A in human and mouse plasma by reversed-phase high-performance liquid chromatography.

05-11-2001

Investigational new drugs

Compatibility and stability of the investigational polypeptide marine anticancer agent kahalalide F in infusion devices.

20-09-2001

Drug development and industrial pharmacy

Development of a lyophilized parenteral pharmaceutical formulation of the investigational polypeptide marine anticancer agent kahalalide F.

01-09-2001