Publications

Cancer medicine

The role of genetic variants in the prediction of hearing loss due to cisplatin chemoradiotherapy.

JAMA network open

Long-Term Survival in Patients With Advanced Melanoma.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

The association of cognitive coping style with patient preferences in a patient-led follow-up study among colorectal cancer survivors.

EClinicalMedicine

Surgical navigation for targeted retroperitoneal lymph-node removal: a randomised, controlled, phase 3 trial.

Clinical pharmacokinetics

Population Pharmacokinetics and Target Attainment of Allopurinol and Oxypurinol Before, During, and After Cardiac Surgery with Cardiopulmonary Bypass in Neonates with Critical Congenital Heart Disease.

Familial cancer

Attitudes toward genetic testing, family planning and preimplantation genetic testing in families with a germline CDKN2A pathogenic variant.

European journal of nuclear medicine and molecular imaging

Delphi consensus project on prostate-specific membrane antigen (PSMA)-targeted surgery-outcomes from an international multidisciplinary panel.

Therapeutic drug monitoring

Analytical Validation of a Volumetric Absorptive Microsampling Method for Therapeutic Drug Monitoring of the Oral Targeted Anticancer Agents, Abiraterone, Alectinib, Cabozantinib, Imatinib, Olaparib, and Sunitinib, and Metabolites.

Nature genetics

Integrated analyses highlight interactions between the three-dimensional genome and DNA, RNA and epigenomic alterations in metastatic prostate cancer.

The Laryngoscope

Decisional Conflict in Patients with Advanced Laryngeal Carcinoma: A Multicenter Study.

Nature genetics

Competition shapes the landscape of X-chromosome-linked genetic diversity.

PloS one

Head-to-head comparison of composite and individual biomarkers to predict clinical benefit to PD-1 blockade in non-small cell lung cancer.

Nature reviews. Cancer

Rational combination of cancer therapies with PD1 axis blockade.

Nature communications

The small CRL4^CSA ubiquitin ligase component DDA1 regulates transcription-coupled repair dynamics.

bioRxiv : the preprint server for biology

Optimized reporters for multiplexed detection of transcription factor activity.

Cancers

Adverse Events in Anti-PD-1-Treated Adjuvant and First-Line Advanced Melanoma Patients.

PloS one

Head and Neck Paraganglioma (HNPGL) Registry: A study protocol for prospective data collection in patients with Head and Neck Paragangliomas.

BMC cancer

Pembrolizumab plus either epacadostat or placebo for cisplatin-ineligible urothelial carcinoma: results from the ECHO-307/KEYNOTE-672 study.

Nature communications

Single gene analysis in yeast suggests nonequilibrium regulatory dynamics for transcription.

Current biology : CB

Cell biology: Converging paths to cohesion.

Journal of medical genetics

Validation of the BOADICEA model in a prospective cohort of BRCA1/2 pathogenic variant carriers.

iScience

"Radical" differences between two FLIM microscopes affect interpretation of cell signaling dynamics.

Practical radiation oncology

Target Volume Optimization for Localized Prostate Cancer.

Journal of experimental & clinical cancer research : CR

Emerging frontiers in androgen receptor research for prostate Cancer: insights from the 2nd international androgen receptor Symposium.

The regulatory grammar of human promoters uncovered by MPRA-trained deep learning

Nuclear medicine and biology

Transcatheter pseudo-vascular isolation for localization and concentration of a large molecule theranostic probe into a transgenic OncoPIG kidney tumor.

BMC medical genomics

Co-expression in tissue-specific gene networks links genes in cancer-susceptibility loci to known somatic driver genes.

Vaccines

Protection of K18-hACE2 Mice against SARS-CoV-2 Challenge by a Capsid Virus-like Particle-Based Vaccine.

Oncogenesis

Gemcitabine as chemotherapy of head and neck cancer in Fanconi anemia patients.

Journal of the National Comprehensive Cancer Network : JNCCN

Chemotherapy-Induced Peripheral Neuropathy in Patients With Gastroesophageal Cancer.

Cell stem cell

Deciphering lineage specification during early embryogenesis in mouse gastruloids using multilayered proteomics.

Nature communications

Multi-modal generative modeling for joint analysis of single-cell T cell receptor and gene expression data.

Clinical pharmacokinetics

Evaluating the Clinical Impact and Feasibility of Therapeutic Drug Monitoring of Pazopanib in a Real-World Soft-Tissue Sarcoma Cohort.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Patient-reported outcomes after personalised dose-escalation for stage II-III non-small-cell lung cancer patients: Results from the randomised ARTFORCE PET-Boost trial.

Clinical pharmacokinetics

Population Pharmacokinetics of Inotuzumab Ozogamicin in Pediatric Relapsed/Refractory B-Cell Precursor Acute Lymphoblastic Leukemia: Results of Study ITCC-059.

Cancer discovery

Paradoxical Activation of Oncogenic Signaling as a Cancer Treatment Strategy.

The Journal of pathology

Characterization of discordance between mismatch repair deficiency and microsatellite instability testing may prevent inappropriate treatment with immunotherapy.

Cancer discovery

IL2 Targeted to CD8+ T Cells Promotes Robust Effector T-cell Responses and Potent Antitumor Immunity.

Cancer chemotherapy and pharmacology

Impact of loperamide on the pharmacokinetics and tissue disposition of ritonavir-boosted oral docetaxel therapy; a preclinical assessment.

Cancer discovery

CD8-Targeted IL2 Unleashes Tumor-Specific Immunity in Human Cancer Tissue by Reviving the Dysfunctional T-cell Pool.

The Journal of pathology

Ductal carcinoma in situ develops within clonal fields of mutant cells in morphologically normal ducts.

European journal of drug metabolism and pharmacokinetics

The Use of Microdosing for In vivo Phenotyping of Cytochrome P450 Enzymes: Where Do We Stand? A Narrative Review.

Nature genetics

Understanding the genetic complexity of puberty timing across the allele frequency spectrum.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

A multicentric randomized controlled phase III trial of adaptive and 18F-FDG-PET-guided dose-redistribution in locally advanced head and neck squamous cell carcinoma (ARTFORCE).

Nature

Human SARS-CoV-2 challenge uncovers local and systemic response dynamics.

PNAS nexus

Dual role of proliferating cell nuclear antigen monoubiquitination in facilitating Fanconi anemia-mediated interstrand crosslink repair.

Cancer

Employment outcomes of adolescent and young adult cancer survivors and their partners: A Dutch population-based study.

Cancer treatment reviews

Agnostic drug development revisited.

FEBS letters

Nuclear receptor Nur77 and Yin-Yang 1 synergistically increase mitochondrial abundance and activity in macrophages.

The Journal of antimicrobial chemotherapy

Skin pharmacokinetics of miltefosine in the treatment of post-kala-azar dermal leishmaniasis in South Asia.