Publications

Nature communications

The small CRL4^CSA ubiquitin ligase component DDA1 regulates transcription-coupled repair dynamics.

bioRxiv : the preprint server for biology

Optimized reporters for multiplexed detection of transcription factor activity.

Cancers

Adverse Events in Anti-PD-1-Treated Adjuvant and First-Line Advanced Melanoma Patients.

PloS one

Head and Neck Paraganglioma (HNPGL) Registry: A study protocol for prospective data collection in patients with Head and Neck Paragangliomas.

BMC cancer

Pembrolizumab plus either epacadostat or placebo for cisplatin-ineligible urothelial carcinoma: results from the ECHO-307/KEYNOTE-672 study.

Nature communications

Single gene analysis in yeast suggests nonequilibrium regulatory dynamics for transcription.

Current biology : CB

Cell biology: Converging paths to cohesion.

Journal of medical genetics

Validation of the BOADICEA model in a prospective cohort of BRCA1/2 pathogenic variant carriers.

iScience

"Radical" differences between two FLIM microscopes affect interpretation of cell signaling dynamics.

Practical radiation oncology

Target Volume Optimization for Localized Prostate Cancer.

Journal of experimental & clinical cancer research : CR

Emerging frontiers in androgen receptor research for prostate Cancer: insights from the 2nd international androgen receptor Symposium.

The regulatory grammar of human promoters uncovered by MPRA-trained deep learning

Nuclear medicine and biology

Transcatheter pseudo-vascular isolation for localization and concentration of a large molecule theranostic probe into a transgenic OncoPIG kidney tumor.

BMC medical genomics

Co-expression in tissue-specific gene networks links genes in cancer-susceptibility loci to known somatic driver genes.

Vaccines

Protection of K18-hACE2 Mice against SARS-CoV-2 Challenge by a Capsid Virus-like Particle-Based Vaccine.

Oncogenesis

Gemcitabine as chemotherapy of head and neck cancer in Fanconi anemia patients.

Journal of the National Comprehensive Cancer Network : JNCCN

Chemotherapy-Induced Peripheral Neuropathy in Patients With Gastroesophageal Cancer.

Cell stem cell

Deciphering lineage specification during early embryogenesis in mouse gastruloids using multilayered proteomics.

Nature communications

Multi-modal generative modeling for joint analysis of single-cell T cell receptor and gene expression data.

Clinical pharmacokinetics

Evaluating the Clinical Impact and Feasibility of Therapeutic Drug Monitoring of Pazopanib in a Real-World Soft-Tissue Sarcoma Cohort.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Patient-reported outcomes after personalised dose-escalation for stage II-III non-small-cell lung cancer patients: Results from the randomised ARTFORCE PET-Boost trial.

Clinical pharmacokinetics

Population Pharmacokinetics of Inotuzumab Ozogamicin in Pediatric Relapsed/Refractory B-Cell Precursor Acute Lymphoblastic Leukemia: Results of Study ITCC-059.

Cancer discovery

Paradoxical Activation of Oncogenic Signaling as a Cancer Treatment Strategy.

The Journal of pathology

Characterization of discordance between mismatch repair deficiency and microsatellite instability testing may prevent inappropriate treatment with immunotherapy.

Cancer discovery

IL2 Targeted to CD8+ T Cells Promotes Robust Effector T-cell Responses and Potent Antitumor Immunity.

Cancer chemotherapy and pharmacology

Impact of loperamide on the pharmacokinetics and tissue disposition of ritonavir-boosted oral docetaxel therapy; a preclinical assessment.

Cancer discovery

CD8-Targeted IL2 Unleashes Tumor-Specific Immunity in Human Cancer Tissue by Reviving the Dysfunctional T-cell Pool.

The Journal of pathology

Ductal carcinoma in situ develops within clonal fields of mutant cells in morphologically normal ducts.

European journal of drug metabolism and pharmacokinetics

The Use of Microdosing for In vivo Phenotyping of Cytochrome P450 Enzymes: Where Do We Stand? A Narrative Review.

Nature genetics

Understanding the genetic complexity of puberty timing across the allele frequency spectrum.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

A multicentric randomized controlled phase III trial of adaptive and 18F-FDG-PET-guided dose-redistribution in locally advanced head and neck squamous cell carcinoma (ARTFORCE).

Nature

Human SARS-CoV-2 challenge uncovers local and systemic response dynamics.

PNAS nexus

Dual role of proliferating cell nuclear antigen monoubiquitination in facilitating Fanconi anemia-mediated interstrand crosslink repair.

Cancer

Employment outcomes of adolescent and young adult cancer survivors and their partners: A Dutch population-based study.

Cancer treatment reviews

Agnostic drug development revisited.

FEBS letters

Nuclear receptor Nur77 and Yin-Yang 1 synergistically increase mitochondrial abundance and activity in macrophages.

The Journal of antimicrobial chemotherapy

Skin pharmacokinetics of miltefosine in the treatment of post-kala-azar dermal leishmaniasis in South Asia.

Medical physics

Impact of cone-beam computed tomography artifacts on dose calculation accuracy for lung cancer.

Journal for immunotherapy of cancer

Mapping the complexity and diversity of tertiary lymphoid structures in primary and peritoneal metastatic gastric cancer.

Physics and imaging in radiation oncology

Validation of quantitative magnetic resonance imaging techniques in head and neck healthy structures involved in the salivary and swallowing function: Accuracy and repeatability.

Cancer chemotherapy and pharmacology

Impact of bariatric surgery on oral anticancer drugs: an analysis of real-world data.

Cancer discovery

CD70-Targeted Allogeneic CAR T-Cell Therapy for Advanced Clear Cell Renal Cell Carcinoma.

Psychological medicine

The mediating role of health behaviors in the association between depression, anxiety and cancer incidence: an individual participant data meta-analysis.

BJU international

^99mTcPSMA-radioguided surgery in oligorecurrent prostate cancer: the randomised TRACE-II trial.

Cancer discovery

Cancer Core Europe: Leveraging Institutional Synergies to Advance Oncology Research and Care Globally.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

European Society of Radiotherapy and Oncology (ESTRO) strategy 2024-2026: Growth and diversification in a rapidly changing world.

Nature cell biology

Valine aminoacyl-tRNA synthetase promotes therapy resistance in melanoma.

Journal for immunotherapy of cancer

Autoantibody-positivity before and seroconversion during treatment with anti-PD-1 is associated with immune-related adverse events in patients with melanoma.

Nature communications

Alkylamine-tethered molecules recruit FBXO22 for targeted protein degradation.

Biochemical Society transactions

The choreography of chromatin in RNA polymerase III regulation.