Publications

Frontiers in immunology

mRNA-1273 vaccination induces polyfunctional memory CD4 and CD8 T cell responses in patients with solid cancers undergoing immunotherapy or/and chemotherapy.

11-09-2024

Nature communications

Phalloidin and DNase I-bound F-actin pointed end structures reveal principles of filament stabilization and disassembly.

11-09-2024

Acta oncologica (Stockholm, Sweden)

High-dose chemotherapy for patients with stage III breast cancer with homologous recombination deficiency: a discrete choice experiment among healthcare providers.

10-09-2024

Cancer cell

Combination anti-PD-1 and anti-CTLA-4 therapy generates waves of clonal responses that include progenitor-exhausted CD8⁺ T cells.

09-09-2024

The oncologist

High expression of phosphoglycerate dehydrogenase predicts poor outcome in patients with high-grade serous ovarian cancer.

06-09-2024

American journal of human genetics

Co-observation of germline pathogenic variants in breast cancer predisposition genes: Results from analysis of the BRIDGES sequencing dataset.

05-09-2024

medRxiv : the preprint server for health sciences

Analysis of more than 400,000 women provides case-control evidence for BRCA1 and BRCA2 variant classification.

04-09-2024

Clinical cancer research : an official journal of the American Association for Cancer Research

Efficacy of Pembrolizumab and Biomarker Analysis in Patients with WGS-Based Intermediate to High Tumor Mutational Load: Results from the Drug Rediscovery Protocol.

03-09-2024

Clinical cancer research : an official journal of the American Association for Cancer Research

Maximizing Treatment Opportunities: Assessing Protocol Waivers' Impact on Safety and Outcome in the Drug Rediscovery Protocol.

03-09-2024

Toxicology and applied pharmacology

The role of drug efflux and uptake transporters in the plasma pharmacokinetics and tissue disposition of morphine and its main metabolites.

01-09-2024

Bioinformatics (Oxford, England)

CIBRA identifies genomic alterations with a system-wide impact on tumor biology.

01-09-2024

Genetics in medicine : official journal of the American College of Medical Genetics

Cancer risks for other sites in addition to breast in CHEK2 c.1100delC families.

01-09-2024

European urology open science

Feasibility of Diffuse Reflection Spectroscopy for Intraoperative Margin Assessment During Prostatectomy.

01-09-2024

Clinical pharmacology and therapeutics

Therapeutic Drug Monitoring of Oral Oncology Drugs: Finding the Right Nails.

01-09-2024

British journal of cancer

Reasons for non-feasibility of therapeutic drug monitoring of oral targeted therapies in oncology - an analysis of the closed cohorts of a multicentre prospective study.

01-09-2024

Cancer chemotherapy and pharmacology

A joint model of longitudinal pharmacokinetic and time-to-event data to study exposure-response relationships: a proof-of-concept study with alectinib.

01-09-2024

Blood neoplasia

Effect of clofarabine and fludarabine exposure on outcome after pediatric allogeneic hematopoietic cell transplantation.

01-09-2024

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

First-line palliative systemic therapy alternated with oxaliplatin-based pressurized intraperitoneal aerosol chemotherapy for unresectable colorectal peritoneal metastases: A single-arm phase II trial (CRC-PIPAC-II).

01-09-2024

Journal of cell science

Nucleocytoplasmic transport senses mechanical forces independently of cell density in cell monolayers.

01-09-2024

The Journal of urology

Reply by Authors.

01-09-2024

Nature protocols

OBSERVE: guidelines for the refinement of rodent cancer models.

01-09-2024

European journal of cancer (Oxford, England : 1990)

The survival disparity between children and adolescents and young adults (AYAs) with Ewing sarcoma in the Netherlands did not change since the 1990s despite improved survival: A population-based study.

01-09-2024

Trends in cancer

PARPi, BRCA, and gaps: controversies and future research.

01-09-2024

Gynecologic oncology

Effect of reduced follow-up care on patient satisfaction with care among patients with endometrial cancer: The ENSURE randomized controlled trial.

01-09-2024

ESMO open

The clinical use of enfortumab vedotin and pembrolizumab in patients with advanced urothelial carcinoma: using clinical judgement over treatment criteria.

01-09-2024

The Journal of molecular diagnostics : JMD

Mono- and Biallelic Replication-Coupled Gene Editing Discriminates Dominant-Negative and Loss-of-Function Variants of DNA Mismatch Repair Genes.

01-09-2024

The Journal of urology

Location-Based Oncological Outcomes of Sentinel Node Dissection in Radical Prostatectomy.

01-09-2024

BJU international

The psychosocial impact of prostate cancer screening for BRCA1 and BRCA2 carriers.

01-09-2024

European radiology

Artificial intelligence-assisted double reading of chest radiographs to detect clinically relevant missed findings: a two-centre evaluation.

01-09-2024

European urology focus

A Systematic Review on the Impact of Quality Assurance Programs on Outcomes after Radical Prostatectomy.

01-09-2024

Nature

Mechanisms that clear mutations drive field cancerization in mammary tissue.

01-09-2024

Key Publication

NAR cancer

Ribosome specialization in cancer: a spotlight on ribosomal proteins.

01-09-2024

Pediatric blood & cancer

Vincristine exposure in Kenyan children with cancer: CHAPATI feasibility study.

01-09-2024

The Lancet. Oncology

Adjuvant pembrolizumab versus placebo in resected stage III melanoma (EORTC 1325-MG/KEYNOTE-054): long-term, health-related quality-of-life results from a double-blind, randomised, controlled, phase 3 trial.

01-09-2024

British journal of cancer

Invasive recurrence after breast conserving treatment of ductal carcinoma in situ of the breast in the Netherlands: time trends and the association with tumour grade.

01-09-2024

Disability and rehabilitation

Tailoring of exercise and dietary interventions to adverse effects and existing comorbidities in patients with ovarian cancer receiving chemotherapy: a clinical vignettes study among expert physical therapists and dietitians.

01-09-2024

Clinical pharmacokinetics

Pharmacokinetics and Pharmacodynamics of Systemic Corticosteroids in Autoimmune and Inflammatory Diseases: A Review of Current Evidence.

01-09-2024

Medical physics

Deep learning-based low-dose CT simulator for non-linear reconstruction methods.

01-09-2024

Nature structural & molecular biology

Concerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation.

01-09-2024

Fertility and sterility

Interindividual variation in ovarian reserve after gonadotoxic treatment in female childhood cancer survivors - a genome-wide association study: results from PanCareLIFE.

01-09-2024

ESMO real world data and digital oncology

Clinical text mining of the performance status and progression-free survival to facilitate data collection in cancer research: an exploratory study.

01-09-2024

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

Interleukin-6 in relation to early recurrence in primary, localized soft tissue sarcoma: An addition for existing risk classification systems?

01-09-2024

Nucleic acids research

Chromatin context-dependent effects of epigenetic drugs on CRISPR-Cas9 editing.

27-08-2024

Oncoimmunology

Tertiary lymphoid structure-related immune infiltrates in NSCLC tumor lesions correlate with low tumor-reactivity of TIL products.

27-08-2024

Breast cancer research : BCR

Systematic assessment of HER2 status in ductal carcinoma in situ of the breast: a perspective on the potential clinical relevance.

27-08-2024

European radiology experimental

Non-invasive CT radiomic biomarkers predict microsatellite stability status in colorectal cancer: a multicenter validation study.

26-08-2024

Therapeutic advances in medical oncology

Early evaluation of the effectiveness and cost-effectiveness of ctDNA-guided selection for adjuvant chemotherapy in stage II colon cancer.

23-08-2024

Journal of experimental & clinical cancer research : CR

Circulating tumour DNA dynamics predict recurrence in stage III melanoma patients receiving neoadjuvant immunotherapy.

21-08-2024

Cell reports. Medicine

A pan-cancer screen identifies drug combination benefit in cancer cell lines at the individual and population level.

20-08-2024

Diagnostics (Basel, Switzerland)

Separating Surface Reflectance from Volume Reflectance in Medical Hyperspectral Imaging.

20-08-2024

mRNA-1273 vaccination induces polyfunctional memory CD4 and CD8 T cell responses in patients with solid cancers undergoing immunotherapy or/and chemotherapy.

Phalloidin and DNase I-bound F-actin pointed end structures reveal principles of filament stabilization and disassembly.

High-dose chemotherapy for patients with stage III breast cancer with homologous recombination deficiency: a discrete choice experiment among healthcare providers.

Combination anti-PD-1 and anti-CTLA-4 therapy generates waves of clonal responses that include progenitor-exhausted CD8+ T cells.

High expression of phosphoglycerate dehydrogenase predicts poor outcome in patients with high-grade serous ovarian cancer.

Co-observation of germline pathogenic variants in breast cancer predisposition genes: Results from analysis of the BRIDGES sequencing dataset.

Analysis of more than 400,000 women provides case-control evidence for BRCA1 and BRCA2 variant classification.

Efficacy of Pembrolizumab and Biomarker Analysis in Patients with WGS-Based Intermediate to High Tumor Mutational Load: Results from the Drug Rediscovery Protocol.

Maximizing Treatment Opportunities: Assessing Protocol Waivers' Impact on Safety and Outcome in the Drug Rediscovery Protocol.

The role of drug efflux and uptake transporters in the plasma pharmacokinetics and tissue disposition of morphine and its main metabolites.

CIBRA identifies genomic alterations with a system-wide impact on tumor biology.

Cancer risks for other sites in addition to breast in CHEK2 c.1100delC families.

Feasibility of Diffuse Reflection Spectroscopy for Intraoperative Margin Assessment During Prostatectomy.

Therapeutic Drug Monitoring of Oral Oncology Drugs: Finding the Right Nails.

Reasons for non-feasibility of therapeutic drug monitoring of oral targeted therapies in oncology - an analysis of the closed cohorts of a multicentre prospective study.

A joint model of longitudinal pharmacokinetic and time-to-event data to study exposure-response relationships: a proof-of-concept study with alectinib.

Effect of clofarabine and fludarabine exposure on outcome after pediatric allogeneic hematopoietic cell transplantation.

First-line palliative systemic therapy alternated with oxaliplatin-based pressurized intraperitoneal aerosol chemotherapy for unresectable colorectal peritoneal metastases: A single-arm phase II trial (CRC-PIPAC-II).

Nucleocytoplasmic transport senses mechanical forces independently of cell density in cell monolayers.

Reply by Authors.

OBSERVE: guidelines for the refinement of rodent cancer models.

The survival disparity between children and adolescents and young adults (AYAs) with Ewing sarcoma in the Netherlands did not change since the 1990s despite improved survival: A population-based study.

PARPi, BRCA, and gaps: controversies and future research.

Effect of reduced follow-up care on patient satisfaction with care among patients with endometrial cancer: The ENSURE randomized controlled trial.

The clinical use of enfortumab vedotin and pembrolizumab in patients with advanced urothelial carcinoma: using clinical judgement over treatment criteria.

Mono- and Biallelic Replication-Coupled Gene Editing Discriminates Dominant-Negative and Loss-of-Function Variants of DNA Mismatch Repair Genes.

Location-Based Oncological Outcomes of Sentinel Node Dissection in Radical Prostatectomy.

The psychosocial impact of prostate cancer screening for BRCA1 and BRCA2 carriers.

Artificial intelligence-assisted double reading of chest radiographs to detect clinically relevant missed findings: a two-centre evaluation.

A Systematic Review on the Impact of Quality Assurance Programs on Outcomes after Radical Prostatectomy.

Mechanisms that clear mutations drive field cancerization in mammary tissue.

Ribosome specialization in cancer: a spotlight on ribosomal proteins.

Vincristine exposure in Kenyan children with cancer: CHAPATI feasibility study.

Adjuvant pembrolizumab versus placebo in resected stage III melanoma (EORTC 1325-MG/KEYNOTE-054): long-term, health-related quality-of-life results from a double-blind, randomised, controlled, phase 3 trial.

Invasive recurrence after breast conserving treatment of ductal carcinoma in situ of the breast in the Netherlands: time trends and the association with tumour grade.

Tailoring of exercise and dietary interventions to adverse effects and existing comorbidities in patients with ovarian cancer receiving chemotherapy: a clinical vignettes study among expert physical therapists and dietitians.

Pharmacokinetics and Pharmacodynamics of Systemic Corticosteroids in Autoimmune and Inflammatory Diseases: A Review of Current Evidence.

Deep learning-based low-dose CT simulator for non-linear reconstruction methods.

Concerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation.

Interindividual variation in ovarian reserve after gonadotoxic treatment in female childhood cancer survivors - a genome-wide association study: results from PanCareLIFE.

Clinical text mining of the performance status and progression-free survival to facilitate data collection in cancer research: an exploratory study.

Interleukin-6 in relation to early recurrence in primary, localized soft tissue sarcoma: An addition for existing risk classification systems?

Chromatin context-dependent effects of epigenetic drugs on CRISPR-Cas9 editing.

Tertiary lymphoid structure-related immune infiltrates in NSCLC tumor lesions correlate with low tumor-reactivity of TIL products.

Systematic assessment of HER2 status in ductal carcinoma in situ of the breast: a perspective on the potential clinical relevance.

Non-invasive CT radiomic biomarkers predict microsatellite stability status in colorectal cancer: a multicenter validation study.

Early evaluation of the effectiveness and cost-effectiveness of ctDNA-guided selection for adjuvant chemotherapy in stage II colon cancer.

Circulating tumour DNA dynamics predict recurrence in stage III melanoma patients receiving neoadjuvant immunotherapy.

A pan-cancer screen identifies drug combination benefit in cancer cell lines at the individual and population level.

Separating Surface Reflectance from Volume Reflectance in Medical Hyperspectral Imaging.

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Combination anti-PD-1 and anti-CTLA-4 therapy generates waves of clonal responses that include progenitor-exhausted CD8⁺ T cells.