Publications

Clinical and translational radiation oncology

Safety and early organ preservation outcomes after dose escalation with MR-guided radiotherapy for rectal cancer (preRADAR): A phase I trial.

01-09-2026

Clinical cancer research : an official journal of the American Association for Cancer Research

plasmaCHORD: A Machine Learning Approach to Distinguish Clonal Hematopoiesis-Derived Variants in Liquid Biopsies from Patients with Solid Tumors.

01-05-2026

Nature communications

TrialMatchAI: an end-to-end AI-powered clinical trial recommendation system to streamline patient-to-trial matching.

25-03-2026

Scientific data

A comprehensive European Colorectal Cancer Cohort dataset.

12-03-2026

European journal of cancer (Oxford, England : 1990)

Cancer-associated fibroblast signature and SMAD4 mutation in resistance to adjuvant chemotherapy in stage III colon cancer patients.

11-03-2026

Cell reports

Aneuploidy patterns in colorectal cancer.

27-01-2026

ESMO open

Added value of tumor-stroma ratio to postsurgery circulating tumor DNA and pTN stage in risk stratification of patients with stage III colon cancer treated with adjuvant chemotherapy.

01-01-2026

EBioMedicine

Combining cell-free DNA fragmentomes and total tumour volume improves prognostication and tumour response evaluation in patients with colorectal cancer liver metastases.

01-01-2026

The British journal of surgery

Circulating tumour DNA in patients with stage III colon cancer: multicentre prospective PROVENC3 study.

24-12-2025

Therapeutic advances in medical oncology

CtDNA-guided de-escalation of adjuvant chemotherapy in stage III colon cancer: early model-based evaluation of cost-effectiveness.

10-11-2025

Physics and imaging in radiation oncology

Apparent diffusion coefficient increases during short course radiotherapy in rectal tumours: Results from a multicentre longitudinal trial.

01-10-2025

International journal of radiation oncology, biology, physics

Quality of Life and Toxicity in Patients With Pancreatic Ductal Adenocarcinoma Treated With Online Adaptive Stereotactic Magnetic Resonance Guided Radiation Therapy.

01-07-2025

Gastroenterology

Reply.

01-06-2025

NPJ precision oncology

Tumor break load quantitates structural variant-associated genomic instability with biological and clinical relevance across cancers.

14-05-2025

PharmacoEconomics

Towards Recommendations for Cost-Effectiveness Analysis of Predictive, Prognostic, and Serial Biomarker Tests in Oncology.

01-05-2025

Digestive diseases and sciences

Developing a New Stool Test for Colorectal Cancer Screening, the multitargetFIT (mtFIT).

01-05-2025

The American journal of gastroenterology

Fecal Immunochemical Test to Detect Colorectal Neoplasia in Lynch Syndrome: A Prospective Multicenter Study.

01-03-2025

Cancer discovery

Early Detection of Ovarian Cancer Using Cell-Free DNA Fragmentomes and Protein Biomarkers.

13-01-2025

Gastroenterology

Combining Colonoscopy With Fecal Immunochemical Test Can Improve Current Familial Colorectal Cancer Colonoscopy Surveillance: A Modelling Study.

01-01-2025

Gastroenterology

Stool-Based Testing for Post-Polypectomy Colorectal Cancer Surveillance Safely Reduces Colonoscopies: The MOCCAS Study.

01-01-2025

Alimentary pharmacology & therapeutics

Faecal Volatile Organic Compounds to Detect Colorectal Neoplasia in Lynch Syndrome-A Prospective Longitudinal Multicentre Study.

01-01-2025

The Journal of molecular diagnostics : JMD

High Prevalence of Chromosomal Rearrangements and LINE Retrotranspositions Detected in Formalin-Fixed, Paraffin-Embedded Colorectal Cancer Tissue.

01-12-2024

Molecular oncology

A scenario-drafting study to explore potential future implementation pathways of circulating tumor DNA testing in oncology.

01-11-2024

Clinical and translational radiation oncology

Feasibility and safety of single-fraction sub-ablative radiotherapy with systemic therapy in colorectal cancer patients with ≤ 10 metastases: A multicenter pilot study (NCT05375708).

01-11-2024

Nature communications

Cancer treatment monitoring using cell-free DNA fragmentomes.

21-10-2024

Bioinformatics (Oxford, England)

CIBRA identifies genomic alterations with a system-wide impact on tumor biology.

01-09-2024

Therapeutic advances in medical oncology

Early evaluation of the effectiveness and cost-effectiveness of ctDNA-guided selection for adjuvant chemotherapy in stage II colon cancer.

23-08-2024

PloS one

Head-to-head comparison of composite and individual biomarkers to predict clinical benefit to PD-1 blockade in non-small cell lung cancer.

31-07-2024

The Journal of pathology

Polyketide synthase positive Escherichia coli one-time measurement in stool is not informative of colorectal cancer risk in a screening setting.

01-06-2024

Endoscopy

Post-colonoscopy colorectal cancers in a national fecal immunochemical test-based colorectal cancer screening program.

01-05-2024

Cancer cell

Improved detection of colibactin-induced mutations by genotoxic E. coli in organoids and colorectal cancer.

11-03-2024

The journal of pathology. Clinical research

Aberrant PRDM2 methylation as an early event in serrated lesions destined to evolve into microsatellite-instable colorectal cancers.

01-03-2024

The Lancet. Oncology

The multitarget faecal immunochemical test for improving stool-based colorectal cancer screening programmes: a Dutch population-based, paired-design, intervention study.

01-03-2024

Nature protocols

Optimized whole-genome sequencing workflow for tumor diagnostics in routine pathology practice.

01-03-2024

Clinical cancer research : an official journal of the American Association for Cancer Research

A Dysfunctional T-cell Gene Signature for Predicting Nonresponse to PD-1 Blockade in Non-small Cell Lung Cancer That Is Suitable for Routine Clinical Diagnostics.

16-02-2024

Genetics in medicine : official journal of the American College of Medical Genetics

Impact of genetic counseling strategy on diagnostic yield and workload for genome-sequencing-based tumor diagnostics.

01-02-2024

Cancers

Identifying Genetic Mutation Status in Patients with Colorectal Cancer Liver Metastases Using Radiomics-Based Machine-Learning Models.

29-11-2023

Cancer research communications

Risk Prediction of Metachronous Colorectal Cancer from Molecular Features of Adenomas: A Nested Case-Control Study.

13-11-2023

Expert review of molecular diagnostics

Cross-sectional risk models using quantitative fecal hemoglobin in colorectal cancer screening: a systematic review.

06-11-2023

Gut

An efficient strategy for evaluating new non-invasive screening tests for colorectal cancer: the guiding principles.

01-10-2023

Journal for immunotherapy of cancer

Cell-free DNA approaches for cancer early detection and interception.

01-09-2023

BMJ open

Towards Response ADAptive Radiotherapy for organ preservation for intermediate-risk rectal cancer (preRADAR): protocol of a phase I dose-escalation trial.

15-06-2023

Clinical cancer research : an official journal of the American Association for Cancer Research

Metastatic Colorectal Cancer Treatment Response Evaluation by Ultra-Deep Sequencing of Cell-Free DNA and Matched White Blood Cells.

01-03-2023

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

Initial Impact of National CRC Screening on Incidence and Advanced Colorectal Cancer.

01-03-2023

The Journal of molecular diagnostics : JMD

A Micro-Costing Framework for Circulating Tumor DNA Testing in Dutch Clinical Practice.

01-01-2023

BMC cancer

The multitarget fecal immunochemical test versus the fecal immunochemical test for programmatic colorectal cancer screening: a cross-sectional intervention study with paired design.

12-12-2022

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Cost-Effectiveness of Colorectal Cancer Surveillance in Hodgkin Lymphoma Survivors Treated with Procarbazine and/or Infradiaphragmatic Radiotherapy.

05-12-2022

European journal of cancer (Oxford, England : 1990)

Tumour break load is a biologically relevant feature of genomic instability with prognostic value in colorectal cancer.

01-12-2022

ESMO open

Complete genomic characterization in patients with cancer of unknown primary origin in routine diagnostics.

01-12-2022

Epigenetics

Evaluation of methylated DCR1 as a biomarker for response to adjuvant irinotecan-based therapy in stage III colon cancer: cancer and leukaemia Group B 89803 (Alliance).

01-12-2022

Safety and early organ preservation outcomes after dose escalation with MR-guided radiotherapy for rectal cancer (preRADAR): A phase I trial.

plasmaCHORD: A Machine Learning Approach to Distinguish Clonal Hematopoiesis-Derived Variants in Liquid Biopsies from Patients with Solid Tumors.

TrialMatchAI: an end-to-end AI-powered clinical trial recommendation system to streamline patient-to-trial matching.

A comprehensive European Colorectal Cancer Cohort dataset.

Cancer-associated fibroblast signature and SMAD4 mutation in resistance to adjuvant chemotherapy in stage III colon cancer patients.

Aneuploidy patterns in colorectal cancer.

Added value of tumor-stroma ratio to postsurgery circulating tumor DNA and pTN stage in risk stratification of patients with stage III colon cancer treated with adjuvant chemotherapy.

Combining cell-free DNA fragmentomes and total tumour volume improves prognostication and tumour response evaluation in patients with colorectal cancer liver metastases.

Circulating tumour DNA in patients with stage III colon cancer: multicentre prospective PROVENC3 study.

CtDNA-guided de-escalation of adjuvant chemotherapy in stage III colon cancer: early model-based evaluation of cost-effectiveness.

Apparent diffusion coefficient increases during short course radiotherapy in rectal tumours: Results from a multicentre longitudinal trial.

Quality of Life and Toxicity in Patients With Pancreatic Ductal Adenocarcinoma Treated With Online Adaptive Stereotactic Magnetic Resonance Guided Radiation Therapy.

Reply.

Tumor break load quantitates structural variant-associated genomic instability with biological and clinical relevance across cancers.

Towards Recommendations for Cost-Effectiveness Analysis of Predictive, Prognostic, and Serial Biomarker Tests in Oncology.

Developing a New Stool Test for Colorectal Cancer Screening, the multitargetFIT (mtFIT).

Fecal Immunochemical Test to Detect Colorectal Neoplasia in Lynch Syndrome: A Prospective Multicenter Study.

Early Detection of Ovarian Cancer Using Cell-Free DNA Fragmentomes and Protein Biomarkers.

Combining Colonoscopy With Fecal Immunochemical Test Can Improve Current Familial Colorectal Cancer Colonoscopy Surveillance: A Modelling Study.

Stool-Based Testing for Post-Polypectomy Colorectal Cancer Surveillance Safely Reduces Colonoscopies: The MOCCAS Study.

Faecal Volatile Organic Compounds to Detect Colorectal Neoplasia in Lynch Syndrome-A Prospective Longitudinal Multicentre Study.

High Prevalence of Chromosomal Rearrangements and LINE Retrotranspositions Detected in Formalin-Fixed, Paraffin-Embedded Colorectal Cancer Tissue.

A scenario-drafting study to explore potential future implementation pathways of circulating tumor DNA testing in oncology.

Feasibility and safety of single-fraction sub-ablative radiotherapy with systemic therapy in colorectal cancer patients with ≤ 10 metastases: A multicenter pilot study (NCT05375708).

Cancer treatment monitoring using cell-free DNA fragmentomes.

CIBRA identifies genomic alterations with a system-wide impact on tumor biology.

Early evaluation of the effectiveness and cost-effectiveness of ctDNA-guided selection for adjuvant chemotherapy in stage II colon cancer.

Head-to-head comparison of composite and individual biomarkers to predict clinical benefit to PD-1 blockade in non-small cell lung cancer.

Polyketide synthase positive Escherichia coli one-time measurement in stool is not informative of colorectal cancer risk in a screening setting.

Post-colonoscopy colorectal cancers in a national fecal immunochemical test-based colorectal cancer screening program.

Improved detection of colibactin-induced mutations by genotoxic E. coli in organoids and colorectal cancer.

Aberrant PRDM2 methylation as an early event in serrated lesions destined to evolve into microsatellite-instable colorectal cancers.

The multitarget faecal immunochemical test for improving stool-based colorectal cancer screening programmes: a Dutch population-based, paired-design, intervention study.

Optimized whole-genome sequencing workflow for tumor diagnostics in routine pathology practice.

A Dysfunctional T-cell Gene Signature for Predicting Nonresponse to PD-1 Blockade in Non-small Cell Lung Cancer That Is Suitable for Routine Clinical Diagnostics.

Impact of genetic counseling strategy on diagnostic yield and workload for genome-sequencing-based tumor diagnostics.

Identifying Genetic Mutation Status in Patients with Colorectal Cancer Liver Metastases Using Radiomics-Based Machine-Learning Models.

Risk Prediction of Metachronous Colorectal Cancer from Molecular Features of Adenomas: A Nested Case-Control Study.

Cross-sectional risk models using quantitative fecal hemoglobin in colorectal cancer screening: a systematic review.

An efficient strategy for evaluating new non-invasive screening tests for colorectal cancer: the guiding principles.

Cell-free DNA approaches for cancer early detection and interception.

Towards Response ADAptive Radiotherapy for organ preservation for intermediate-risk rectal cancer (preRADAR): protocol of a phase I dose-escalation trial.

Metastatic Colorectal Cancer Treatment Response Evaluation by Ultra-Deep Sequencing of Cell-Free DNA and Matched White Blood Cells.

Initial Impact of National CRC Screening on Incidence and Advanced Colorectal Cancer.

A Micro-Costing Framework for Circulating Tumor DNA Testing in Dutch Clinical Practice.

The multitarget fecal immunochemical test versus the fecal immunochemical test for programmatic colorectal cancer screening: a cross-sectional intervention study with paired design.

Cost-Effectiveness of Colorectal Cancer Surveillance in Hodgkin Lymphoma Survivors Treated with Procarbazine and/or Infradiaphragmatic Radiotherapy.

Tumour break load is a biologically relevant feature of genomic instability with prognostic value in colorectal cancer.

Complete genomic characterization in patients with cancer of unknown primary origin in routine diagnostics.

Evaluation of methylated DCR1 as a biomarker for response to adjuvant irinotecan-based therapy in stage III colon cancer: cancer and leukaemia Group B 89803 (Alliance).

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