Early Detection of Ovarian Cancer Using Cell-Free DNA Fragmentomes and Protein Biomarkers.
Jamie E Medina,
Akshaya V Annapragada,
Pien Lof,
Sarah Short,
Adrianna L Bartolomucci,
Dimitrios Mathios,
Shashikant Koul,
Noushin Niknafs,
Michaël Noë,
Zachariah H Foda,
Daniel C Bruhm,
Carolyn Hruban,
Nicholas A Vulpescu,
Euihye Jung,
Renu Dua,
Jenna V Canzoniero,
Stephen Cristiano,
Vilmos Adleff,
Heather Symecko,
Daan van den Broek,
Lori J Sokoll,
Stephen B Baylin,
Michael F Press,
Dennis J Slamon,
Gottfried E Konecny,
Christina Therkildsen,
Beatriz Carvalho,
Gerrit A Meijer,
Claus Lindbjerg Andersen,
Susan M Domchek,
Ronny Drapkin,
Robert B Scharpf,
Jillian Phallen,
Christine A R Lok,
Victor E Velculescu
Abstract
There is an unmet need for effective ovarian cancer screening and diagnostic approaches that enable earlier-stage cancer detection and increased overall survival. We have developed a high-performing accessible approach that evaluates cfDNA fragmentomes and protein biomarkers to detect ovarian cancer.