Publications

Cancer cell

Biomarkers in cancer immunotherapy.

12-01-2015

Nature medicine

High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma.

01-01-2015

Nature

Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens.

27-11-2014

Cell reports

Parallel in vivo and in vitro melanoma RNAi dropout screens reveal synthetic lethality between hypoxia and DNA damage response inhibition.

20-11-2014

Journal of immunology (Baltimore, Md. : 1950)

Altered peptide ligands revisited: vaccine design through chemically modified HLA-A2-restricted T cell epitopes.

15-11-2014

Molecular therapy : the journal of the American Society of Gene Therapy

RNAi-mediated TCR knockdown prevents autoimmunity in mice caused by mixed TCR dimers following TCR gene transfer.

01-11-2014

Science (New York, N.Y.)

T cell memory. Skin-resident memory CD8⁺ T cells trigger a state of tissue-wide pathogen alert.

03-10-2014

Human gene therapy methods

Manufacture of gene-modified human T-cells with a memory stem/central memory phenotype.

01-10-2014

Science translational medicine

Anti-CTLA-4 therapy broadens the melanoma-reactive CD8+ T cell response.

17-09-2014

Molecular oncology

Acquired and intrinsic resistance in cancer immunotherapy.

12-09-2014

Experimental hematology

Barriers to chimerism after major histocompatibility complex-mismatched stem cell transplantation: a potential role for heterologous immunity.

01-09-2014

Oncoimmunology

High sensitivity of cancer exome-based CD8 T cell neo-antigen identification.

02-08-2014

Experimental hematology

Cellular barcoding: a technical appraisal.

01-08-2014

Nature methods

Towards error-free profiling of immune repertoires.

01-06-2014

Cancer immunology, immunotherapy : CII

Lactate dehydrogenase as a selection criterion for ipilimumab treatment in metastatic melanoma.

01-05-2014

Methods in molecular biology (Clifton, N.J.)

Intradermal vaccination by DNA tattooing.

10-04-2014

Trends in immunology

Single cell behavior in T cell differentiation.

01-04-2014

Cell reports

Determining lineage pathways from cellular barcoding experiments.

27-02-2014

Journal of immunology (Baltimore, Md. : 1950)

HLA micropolymorphisms strongly affect peptide-MHC multimer-based monitoring of antigen-specific CD8+ T cell responses.

15-01-2014

Immunological reviews

TCR repertoires of intratumoral T-cell subsets.

01-01-2014

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Tumor exome analysis reveals neoantigen-specific T-cell reactivity in an ipilimumab-responsive melanoma.

10-11-2013

Nature medicine

High-throughput identification of antigen-specific TCRs by TCR gene capture.

01-11-2013

Journal of immunology (Baltimore, Md. : 1950)

Blockade of TGF-β signaling greatly enhances the efficacy of TCR gene therapy of cancer.

15-09-2013

Vaccine

Transposon leads to contamination of clinical pDNA vaccine.

11-07-2013

Science (New York, N.Y.)

Heterogeneous differentiation patterns of individual CD8+ T cells.

03-05-2013

Nature

Diverse and heritable lineage imprinting of early haematopoietic progenitors.

11-04-2013

Current opinion in immunology

Human cancer regression antigens.

01-04-2013

The EMBO journal

The cancer antigenome.

23-01-2013

Chembiochem : a European journal of chemical biology

Development of a hypersensitive periodate-cleavable amino acid that is methionine- and disulfide-compatible and its application in MHC exchange reagents for T cell characterisation.

02-01-2013

Human gene therapy

Rational design of DNA vaccines for the induction of human papillomavirus type 16 E6- and E7-specific cytotoxic T-cell responses.

01-12-2012

Proceedings of the National Academy of Sciences of the United States of America

Tissue-resident memory CD8+ T cells continuously patrol skin epithelia to quickly recognize local antigen.

27-11-2012

Oncoimmunology

Selective BRAF inhibition decreases tumor-resident lymphocyte frequencies in a mouse model of human melanoma.

01-08-2012

Oncoimmunology

TIL therapy broadens the tumor-reactive CD8(+) T cell compartment in melanoma patients.

01-07-2012

Advances in immunology

Behavior and function of tissue-resident memory T cells.

28-03-2012

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Ipilimumab-induced sarcoidosis in a patient with metastatic melanoma undergoing complete remission.

10-01-2012

Results in immunology

Testing for HLA/peptide tetramer-binding to the T cell receptor complex on human T lymphocytes.

01-01-2012

Cancer immunology, immunotherapy : CII

Combination of targeted therapy and immunotherapy in melanoma.

01-10-2011

The Journal of investigative dermatology

T-cell receptor gene therapy: critical parameters for clinical success.

01-09-2011

Current gene therapy

Prospects and limitations of T cell receptor gene therapy.

01-08-2011

International journal of cancer

Preclinical development of highly effective and safe DNA vaccines directed against HPV 16 E6 and E7.

15-07-2011

Annals of the New York Academy of Sciences

The descent of memory T cells.

01-01-2011

Current topics in microbiology and immunology

DNA vaccines and intradermal vaccination by DNA tattooing.

26-11-2010

Human gene therapy

Microbead-assisted retroviral transduction for clinical application.

01-10-2010

Journal of proteomics

Technologies for MHC class I immunoproteomics.

10-09-2010

Nature reviews. Immunology

Mapping the life histories of T cells.

01-09-2010

Cancer immunology, immunotherapy : CII

RNA interference targeting programmed death receptor-1 improves immune functions of tumor-specific T cells.

01-08-2010

The Journal of experimental medicine

One naive T cell, multiple fates in CD8+ T cell differentiation.

07-06-2010

International journal of pharmaceutics

Lipopolysaccharide contamination in intradermal DNA vaccination: toxic impurity or adjuvant?

05-05-2010

Nature medicine

Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy.

01-05-2010

Current protocols in immunology

Generation of peptide MHC class I monomers and multimers through ligand exchange.

01-11-2009

Biomarkers in cancer immunotherapy.

High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma.

Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens.

Parallel in vivo and in vitro melanoma RNAi dropout screens reveal synthetic lethality between hypoxia and DNA damage response inhibition.

Altered peptide ligands revisited: vaccine design through chemically modified HLA-A2-restricted T cell epitopes.

RNAi-mediated TCR knockdown prevents autoimmunity in mice caused by mixed TCR dimers following TCR gene transfer.

T cell memory. Skin-resident memory CD8⁺ T cells trigger a state of tissue-wide pathogen alert.

Manufacture of gene-modified human T-cells with a memory stem/central memory phenotype.

Anti-CTLA-4 therapy broadens the melanoma-reactive CD8+ T cell response.

Acquired and intrinsic resistance in cancer immunotherapy.

Barriers to chimerism after major histocompatibility complex-mismatched stem cell transplantation: a potential role for heterologous immunity.

High sensitivity of cancer exome-based CD8 T cell neo-antigen identification.

Cellular barcoding: a technical appraisal.

Towards error-free profiling of immune repertoires.

Lactate dehydrogenase as a selection criterion for ipilimumab treatment in metastatic melanoma.

Intradermal vaccination by DNA tattooing.

Single cell behavior in T cell differentiation.

Determining lineage pathways from cellular barcoding experiments.

HLA micropolymorphisms strongly affect peptide-MHC multimer-based monitoring of antigen-specific CD8+ T cell responses.

TCR repertoires of intratumoral T-cell subsets.

Tumor exome analysis reveals neoantigen-specific T-cell reactivity in an ipilimumab-responsive melanoma.

High-throughput identification of antigen-specific TCRs by TCR gene capture.

Blockade of TGF-β signaling greatly enhances the efficacy of TCR gene therapy of cancer.

Transposon leads to contamination of clinical pDNA vaccine.

Heterogeneous differentiation patterns of individual CD8+ T cells.

Diverse and heritable lineage imprinting of early haematopoietic progenitors.

Human cancer regression antigens.

The cancer antigenome.

Development of a hypersensitive periodate-cleavable amino acid that is methionine- and disulfide-compatible and its application in MHC exchange reagents for T cell characterisation.

Rational design of DNA vaccines for the induction of human papillomavirus type 16 E6- and E7-specific cytotoxic T-cell responses.

Tissue-resident memory CD8+ T cells continuously patrol skin epithelia to quickly recognize local antigen.

Selective BRAF inhibition decreases tumor-resident lymphocyte frequencies in a mouse model of human melanoma.

TIL therapy broadens the tumor-reactive CD8(+) T cell compartment in melanoma patients.

Behavior and function of tissue-resident memory T cells.

Ipilimumab-induced sarcoidosis in a patient with metastatic melanoma undergoing complete remission.

Testing for HLA/peptide tetramer-binding to the T cell receptor complex on human T lymphocytes.

Combination of targeted therapy and immunotherapy in melanoma.

T-cell receptor gene therapy: critical parameters for clinical success.

Prospects and limitations of T cell receptor gene therapy.

Preclinical development of highly effective and safe DNA vaccines directed against HPV 16 E6 and E7.

The descent of memory T cells.

DNA vaccines and intradermal vaccination by DNA tattooing.

Microbead-assisted retroviral transduction for clinical application.

Technologies for MHC class I immunoproteomics.

Mapping the life histories of T cells.

RNA interference targeting programmed death receptor-1 improves immune functions of tumor-specific T cells.

One naive T cell, multiple fates in CD8+ T cell differentiation.

Lipopolysaccharide contamination in intradermal DNA vaccination: toxic impurity or adjuvant?

Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy.

Generation of peptide MHC class I monomers and multimers through ligand exchange.

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