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Psychosocial Research and Epidemiology: Lonneke van de Poll

Lonneke

Prof. Lonneke van de PollGroup Leader (Group Leader, Professor at Tilburg University)

About Lonneke van de Poll

Cancer Survivorship
Today, 10 million people in Europe survived cancer for 5 years or longer, being at risk for a range of adverse effects. However, our understanding of health decline (symptom development, deteriorated quality of life, functional decline, disease progression and onset of comorbidity) after cancer is still in its infancy. The overarching goal of my research is to understand which patients are vulnerable to develop long-term and late effects of cancer treatment, and to investigate interventions that can prevent or alleviate these negative health outcomes.  

Patient reported outcome assessment
With my group I have developed experience in the conduct, management and analyses of large population-based studies. In 2009 we started the PROFILES (Patient Reported Outcomes Following Initial treatment and Long-term Evaluation of Survivorship) registry that combines population-based cancer registry data with patient reported outcomes (www.profilesregistry.nl). PROFILES registry has collected PRO data from over 25.000 cancer patients and survivors. In these studies we have shown the impact of cancer and therapies on a range of symptoms and QoL. We have observed that about one in three cancer survivors develop symptoms like fatigue, (neuropathic) pain, cognitive problems, anxiety and depression and deteriorated physical functioning and overall QoL.

Observational studies remain the backbone of our research, of which we have recently expanded the data collection to also include blood samples, body composition, nutrition and biosensor data (to collect objectively measured physiological data). This novel data collection allows us to investigate mechanisms of deteriorated health outcomes after cancer and treatment, which is currently a serious gap in the international cancer survivorship research field.

Development of Patient Reported Outcome Measures (PROMs)
I am an active member of the EORTC Quality of Life group where I am leading the development of disease-specific EORTC QoL questionnaires for patients with lymphoma or chronic lymphocytic leukaemia. Our international phase I-III development was published and we started with the phase IV international validation study of the EORTC QLQ-HL27 (Hodgkin), QLQ-NHL-HG29 (High Grade Non-Hodgkin), QLQ-NHL-LG20 (Low Grade Non-Hodgkin) and QLQ-CLL17 (Chronic Lymphocytic Leukaemia). Furthermore, I am leading the development of an EORTC cancer survivorship questionnaire. In Phase I we have interviewed 575 disease free cancer survivors and performed a systematic literature review. We have started with phase III and aim to develop a generic EORTC cancer survivorship 'core questionnaire' which can be used as a stand-alone questionnaire or in combination with a site specific (survivor) module.

Development and evaluation of health care interventions
Another increasingly important research activity in our group is the conduct of randomized trials. These trials are a logical consequence of our findings in observational studies where patients reported to be unsatisfied with information provision, shared decision making or survivorship care. We have recently finished 2 trials on the impact of survivorship care plans and shared decision making. We are currently running a trial that investigates the impact of a self-management website on patient empowerment and another trial that investigates follow-up care by the general practitioner instead of oncological specialist.

 

Co-workers

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Dr. Marieke van Leeuwen

Postdoctoral fellow

Experience

I attended the University of Amsterdam, where I received degrees in clinical psychology and medial biology. I received my Ph.D. from the VU University, Department of Biological Psychology. My Ph.D. thesis was on the heritability of cognition of pre-adolescents. My current work is focused on the health- related quality of life (HRQL) of cancer survivors. Recently, I've completed an international feasibility study of the HRQL of long-term survivors of testicular and prostate cancer who were treated in the context of EORTC phase III clinical trials. Currently, I'm developing and evaluating an internet-based cognitive behavioral therapy program to alleviate treatment-induced menopausal symptoms in patients with breast cancer.

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Dr. Jacobien Kieffer

Statistical analyst

Experience

My background is in psychological research methods, which I studied at the University of Amsterdam. I obtained my PhD from the Academic Centre of Dentistry (ACTA). My thesis was on methodological issues in oral health-related quality of life research. Throughout my career, I have always had a teacher and/ or advisory role. Therein also lies my interest in my current position as senior statistical analyst. It provides me with the opportunity to be involved in a range of projects and to work collaboratively with colleagues with varying backgrounds and levels of expertise.

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532474 Wollersheim

Barbara Wollersheim

PhD-student

Experience

I obtained my Master's degree in European Public Health and Health Policy and Innovation Management at the University of Maastricht. The combination of these two masters shows my interest in quality and safety of healthcare and research in health sciences in different settings - topics that reflect my PhD project.
Since August 2017 I am part of the department Psychology and Epidemiology at the Netherlands Cancer Institute. As a PhD student, I am performing a randomized, controlled trial to evaluate whether general practitioners-based follow-up care of prostate cancer patients can be as (cost)effective as the current specialist-based follow-up care (PROSPEC study).

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518387 Soolingen

Lianne van Soolingen

PhD-student

Experience

In 2015 I obtained my medical degree at VU University Amsterdam, after which I started working as a junior doctor at the department of Gynecology and Obstetrics at Sint Franciscus Gasthuis and later at the Departments of Internal Medicine, Gastroenterology and Pulmonology at Alrijne Ziekenhuis. My interests in gynecology, internal and geriatric medicine are perfectly expressed in the PhD
project I started working on at the NKI in 2017. My research focusses on optimizing treatment of elderly patients with ovarian cancer. I find the heterogeneity within the elderly intriguing. In the GERSOC-trial we aim to improve differentiation between frail and fit elderly patients to increase treatment completion and quality of life in this vulnerable patient population.

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533974 Janssen

Silvie Janssen, MSc

Research assistant

Experience

I graduated from Wageningen University where I completed both my bachelor and master
Nutrition and Health. My master thesis (NCCO) and internship (University of
Alabama at Birmingham, USA) both focused on cancer research. After graduation I
started as a data cleaner at the department of Psychosocial Research and
Epidemiology at the Netherlands Cancer Institute. Nowadays, I work at the same
department as a research assistant within different projects, of which the
PROSPEC study is one of the main projects. The PROSPEC study is a RCT in which
we compare general practitioners-based follow up care of prostate cancer
patients with the current specialist-based follow-up care.

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Key publications View All Publications

 
 
 

Contact

  • Office manager

    Karin Roede & Danielle Groenewegen

  • Telephone Number

    0031 20 512 2480

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