Publications

The Lancet. Oncology

Doxorubicin alone versus intensified doxorubicin plus ifosfamide for first-line treatment of advanced or metastatic soft-tissue sarcoma: a randomised controlled phase 3 trial.

PLoS genetics

Chromatin landscapes of retroviral and transposon integration profiles.

European journal of cancer (Oxford, England : 1990)

Risk estimations and treatment decisions in early stage breast cancer: agreement among oncologists and the impact of the 70-gene signature.

BioMed research international

Semiphysiological versus empirical modelling of the population pharmacokinetics of free and total cefazolin during pregnancy.

29-03-2014

Molecular cell

Uncovering SUMOylation dynamics during cell-cycle progression reveals FoxM1 as a key mitotic SUMO target protein.

20-03-2014

International journal of cancer

Increased oral availability and brain accumulation of the ALK inhibitor crizotinib by coadministration of the P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) inhibitor elacridar.

15-03-2014

Molecular cell

Assessing kinetics from fixed cells reveals activation of the mitotic entry network at the S/G2 transition.

06-03-2014

Nature

Cancer: Inflammation lights the way to metastasis.

06-03-2014

Human brain mapping

Global and focal white matter integrity in breast cancer survivors 20 years after adjuvant chemotherapy.

European journal of cancer (Oxford, England : 1990)

Local recurrence rates after radiofrequency ablation or resection of colorectal liver metastases. Analysis of the European Organisation for Research and Treatment of Cancer #40004 and #40983.

Cancer letters

Genomic evolution from primary breast carcinoma to distant metastasis: Few copy number changes of breast cancer related genes.

The Lancet. Oncology

Safety and efficacy of vemurafenib in BRAF(V600E) and BRAF(V600K) mutation-positive melanoma (BRIM-3): extended follow-up of a phase 3, randomised, open-label study.

Journal of pharmaceutical and biomedical analysis

Quantitative determination of azacitidine triphosphate in peripheral blood mononuclear cells using liquid chromatography coupled with high-resolution mass spectrometry.

European urology

A hybrid radioactive and fluorescent tracer for sentinel node biopsy in penile carcinoma as a potential replacement for blue dye.

Clinical pharmacokinetics

Predictive value of CYP3A and ABCB1 phenotyping probes for the pharmacokinetics of sunitinib: the ClearSun study.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Association between metformin use and mortality in patients with prostate cancer: explained by confounding by indication?

Molecular pharmacology

Bcrp1;Mdr1a/b;Mrp2 combination knockout mice: altered disposition of the dietary carcinogen PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) and its genotoxic metabolites.

Medical physics

Multi-institutional dosimetric and geometric commissioning of image-guided small animal irradiators.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

The course of health-related quality of life in head and neck cancer patients treated with chemoradiation: a prospective cohort study.

Annals of oncology : official journal of the European Society for Medical Oncology

Long-term responders and survivors on pazopanib for advanced soft tissue sarcomas: subanalysis of two European Organisation for Research and Treatment of Cancer (EORTC) clinical trials 62043 and 62072.

Current opinion in oncology

The perspective of immunotherapy: new molecules and new mechanisms of action in immune modulation.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Dose-response relationship with clinical outcome for lung stereotactic body radiotherapy (SBRT) delivered via online image guidance.

International journal of radiation oncology, biology, physics

Performance of a nomogram predicting disease-specific survival after an R0 resection for gastric cancer in patients receiving postoperative chemoradiation therapy.

International journal of radiation oncology, biology, physics

Combined recipe for clinical target volume and planning target volume margins.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Mid-ventilation based PTV margins in Stereotactic Body Radiotherapy (SBRT): a clinical evaluation.

The Journal of molecular diagnostics : JMD

MammaPrint molecular diagnostics on formalin-fixed, paraffin-embedded tissue.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Treatment adherence in concurrent chemoradiation in patients with locally advanced non-small cell lung carcinoma: results of daily intravenous prehydration.

Cell reports

Determining lineage pathways from cellular barcoding experiments.

27-02-2014

PloS one

Breast cancer subtype specific classifiers of response to neoadjuvant chemotherapy do not outperform classifiers trained on all subtypes.

22-02-2014

ACS chemical biology

Integrating chemical and genetic silencing strategies to identify host kinase-phosphatase inhibitor networks that control bacterial infection.

21-02-2014

Cell cycle (Georgetown, Tex.)

Astral microtubules control redistribution of dynein at the cell cortex to facilitate spindle positioning.

21-02-2014

British journal of cancer

Chronic fatigue in Hodgkin lymphoma survivors and associations with anxiety, depression and comorbidity.

18-02-2014

British journal of cancer

The impact of organisational external peer review on colorectal cancer treatment and survival in the Netherlands.

18-02-2014

British journal of cancer

Impact of rapid genetic counselling and testing on the decision to undergo immediate or delayed prophylactic mastectomy in newly diagnosed breast cancer patients: findings from a randomised controlled trial.

18-02-2014

Nature communications

The nucleosome acidic patch plays a critical role in RNF168-dependent ubiquitination of histone H2A.

13-02-2014

Breast cancer research and treatment

Tamoxifen dose and serum concentrations of tamoxifen and six of its metabolites in routine clinical outpatient care.

Breast (Edinburgh, Scotland)

Time trends and inter-hospital variation in treatment and axillary staging of patients with ductal carcinoma in situ of the breast in the era of screening in Southern Netherlands.

World journal of urology

Do targeted agents offer clinical benefit as presurgical therapy?

Journal of pharmaceutical sciences

Development of an extended-release formulation of capecitabine making use of in vitro-in vivo correlation modelling.

Biomedical chromatography : BMC

Combined quantification of paclitaxel, docetaxel and ritonavir in human feces and urine using LC-MS/MS.

Molecular cancer therapeutics

OATP1A/1B transporters affect irinotecan and SN-38 pharmacokinetics and carboxylesterase expression in knockout and humanized transgenic mice.

Current opinion in genetics & development

Finding effective cancer therapies through loss of function genetic screens.

EMBO reports

RBR E3-ligases at work.

Breast cancer research and treatment

Long-term impact of the 70-gene signature on breast cancer outcome.

Clinical cancer research : an official journal of the American Association for Cancer Research

Molecular pathways: how can BRCA-mutated tumors become resistant to PARP inhibitors?

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

NAD⁺ depletion by APO866 in combination with radiation in a prostate cancer model, results from an in vitro and in vivo study.

Journal of medical genetics

Breast and ovarian cancer risks in a large series of clinically ascertained families with a high proportion of BRCA1 and BRCA2 Dutch founder mutations.

EMBO molecular medicine

Rapid target gene validation in complex cancer mouse models using re-derived embryonic stem cells.

Breast cancer research and treatment

Mammographic screening detects low-risk tumor biology breast cancers.