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A growing role for Aurora A in chromosome instability.

Ana R R Maia ,
Roy G H P van Heesbeen ,
René H Medema

Abstract

Chromosome instability is a major hallmark of cancer, but its molecular causes are still poorly understood. A study now describes how genetic alterations frequently found in colorectal cancer increase microtubule assembly rates during mitosis and promote chromosome instability.

More about this publication

Nature cell biology

Volume 16
Issue nr. 8
Pages 739-41
Publication date 01-08-2014

Full text links

Publisher website (DOI) 10.1038/ncb3018
Europe PubMed Central 25082197
Pubmed 25082197

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