Publications

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Ion suppression, reduced long-term robustness and leakage current of the spray voltage during the ionization of trichloroacetic acid; a case study with a methylmalonic acid assay.

30-05-2023

Pharmaceutics

Optimization of a Quantitative Anti-Drug Antibodies against Infliximab Assay with the Liquid Chromatography-Tandem Mass Spectrometry: A Method Validation Study and Future Perspectives.

12-05-2023

EClinicalMedicine

Influence of germline variations in drug transporters ABCB1 and ABCG2 on intracerebral osimertinib efficacy in patients with non-small cell lung cancer.

01-05-2023

Pharmaceutical research

Exposure-Response Analyses of Olaparib in Real-Life Patients with Ovarian Cancer.

01-05-2023

Journal of controlled release : official journal of the Controlled Release Society

Radiosensitisation by olaparib through focused ultrasound delivery in a diffuse midline glioma model.

01-05-2023

Haematologica

Combination therapy with crizotinib and vinblastine for relapsed or refractory pediatric ALK-positive anaplastic large cell lymphoma.

01-05-2023

Cancer treatment reviews

Clinical development of WEE1 inhibitors in gynecological cancers: A systematic review.

01-04-2023

Frontiers in oncology

Therapeutic drug monitoring guided dosing versus standard dosing of alectinib in advanced ALK positive non-small cell lung cancer patients: Study protocol for an international, multicenter phase IV randomized controlled trial (ADAPT ALEC).

28-03-2023

Journal of pharmaceutical and biomedical analysis

A sensitive liquid chromatographic-mass spectrometry method for the quantification of vincristine in whole blood collected with volumetric absorptive microsampling.

20-02-2023

EJNMMI research

A physiologically based pharmacokinetic model for [⁶⁸Ga]Ga-(HA-)DOTATATE to predict whole-body distribution and tumor sink effects in GEP-NET patients.

03-02-2023

Clinical and translational science

A naïve pooled data approach for extrapolation of Phase 0 microdose trials to therapeutic dosing regimens.

01-02-2023

British journal of clinical pharmacology

Prediction of the pharmacokinetics of pemetrexed with a low test dose: A proof-of-concept study.

01-02-2023

Anti-cancer drugs

Time above threshold plasma concentrations as pharmacokinetic parameter in the comparison of oral and intravenous docetaxel treatment of breast cancer tumors.

01-02-2023

Clinical pharmacology and therapeutics

Prediction of Busulfan Clearance by Predose Plasma Metabolomic Profiling.

01-02-2023

Cancer chemotherapy and pharmacology

Renal function-based versus standard dosing of pemetrexed: a randomized controlled trial.

01-01-2023

Pharmaceutics

Practical Recommendations for the Manipulation of Kinase Inhibitor Formulations to Age-Appropriate Dosage Forms.

17-12-2022

Theranostics

Current use and future potential of (physiologically based) pharmacokinetic modelling of radiopharmaceuticals: a review.

02-12-2022

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

Overestimation of the effect of (fos)aprepitant on intravenous dexamethasone pharmacokinetics requires adaptation of the guidelines for children with chemotherapy-induced nausea and vomiting.

01-12-2022

Clinical pharmacokinetics

Pharmacokinetics and Pharmacodynamics of PARP Inhibitors in Oncology.

01-12-2022

Cancer chemotherapy and pharmacology

Idiopathic hyperammonemic encephalopathy secondary to gemcitabine-cisplatin treatment.

01-11-2022

Clinical pharmacokinetics

Semi-mechanistic Modeling of Hypoxanthine, Xanthine, and Uric Acid Metabolism in Asphyxiated Neonates.

01-11-2022

Frontiers in oncology

Beta-adrenergic receptor blockade in angiosarcoma: Which beta-blocker to choose?

04-10-2022

Pharmaceutical research

Exposure-Response Analysis of Osimertinib in EGFR Mutation Positive Non-Small Cell Lung Cancer Patients in a Real-Life Setting.

01-10-2022

Breast cancer research and treatment

The influence of body mass index on the tolerability and effectiveness of full-weight-based paclitaxel chemotherapy in women with early-stage breast cancer.

01-10-2022

Pharmaceutical research

A Population Pharmacokinetic Modelling Approach to Unravel the Complex Pharmacokinetics of Vincristine in Children.

01-10-2022

Annals of oncology : official journal of the European Society for Medical Oncology

Therapeutic drug monitoring-based precision dosing of oral targeted therapies in oncology: a prospective multicenter study.

01-10-2022

The oncologist

A Single-arm Phase II Study Combining NLG207, a Nanoparticle Camptothecin, with Enzalutamide in Advanced Metastatic Castration-resistant Prostate Cancer Post-Enzalutamide.

02-09-2022

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Feasibility of therapeutic drug monitoring of sorafenib in patients with liver or thyroid cancer.

01-09-2022

Therapeutic drug monitoring

Everolimus Concentration in Saliva to Predict Stomatitis: A Feasibility Study in Patients with Cancer.

01-08-2022

Clinical and translational science

Longitudinal nonlinear mixed effects modeling of EGFR mutations in ctDNA as predictor of disease progression in treatment of EGFR-mutant non-small cell lung cancer.

01-08-2022

Clinical pharmacology and therapeutics

Presence of Five Chemotherapeutic Drugs in Breast Milk as a Guide for the Safe Use of Chemotherapy During Breastfeeding: Results From a Case Series.

01-08-2022

Pharmaceuticals (Basel, Switzerland)

Predictiveness of the Human-CYP3A4-Transgenic Mouse Model (Cyp3aXAV) for Human Drug Exposure of CYP3A4-Metabolized Drugs.

13-07-2022

Cancer chemotherapy and pharmacology

Efficacy and toxicity of vemurafenib and cobimetinib in relation to plasma concentrations, after administration via feeding tube in patients with BRAF-mutated thyroid cancer: a case series and review of literature.

01-07-2022

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

Stability study of concentrate-solvent mixture & infusion solutions of Jevtana® cabazitaxel for extended multi-dosing.

01-07-2022

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

Image-based analysis of skeletal muscle mass predicts cisplatin dose-limiting toxicity in patients with locally advanced head and neck cancer.

01-07-2022

Cancer chemotherapy and pharmacology

Development of a population pharmacokinetic/pharmacodynamic model for various oral paclitaxel formulations co-administered with ritonavir and thrombospondin-1 based on data from early phase clinical studies.

01-07-2022

Frontiers in pharmacology

Editorial: Therapeutic Drug Monitoring (TDM): A Useful Tool for Pediatric Pharmacology Applied to Routine Clinical Practice.

11-06-2022

Journal of pharmaceutical and biomedical analysis

A highly sensitive bioanalytical method for the quantification of vinblastine, vincristine, vinorelbine and 4-O-deacetylvinorelbine in human plasma using LC-MS/MS.

05-06-2022

British journal of cancer

Peritoneal metastases from colorectal cancer belong to Consensus Molecular Subtype 4 and are sensitised to oxaliplatin by inhibiting reducing capacity.

01-06-2022

Journal of cachexia, sarcopenia and muscle

The association between skeletal muscle measures and chemotherapy-induced toxicity in non-small cell lung cancer patients.

01-06-2022

Scientific reports

Deep learning body-composition analysis of clinically acquired CT-scans estimates creatinine excretion with high accuracy in patients and healthy individuals.

30-05-2022

Cancer chemotherapy and pharmacology

Is age just a number? A population pharmacokinetic study of gemcitabine.

01-05-2022

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Optimized sample pre-treatment procedure for the simultaneous UPLC-MS/MS quantification of ipilimumab, nivolumab, and pembrolizumab in human serum.

30-04-2022

Blood advances

Fludarabine exposure predicts outcome after CD19 CAR T-cell therapy in children and young adults with acute leukemia.

12-04-2022

Clinical pharmacokinetics

Correction to: Unbound Plasma, Total Plasma and Whole-Blood Tacrolimus Pharmacokinetics Early After Thoracic Organ Transplantation.

01-04-2022

Pharmaceutical research

Ritonavir-Boosted Exposure of Kinase Inhibitors: an Open Label, Cross-over Pharmacokinetic Proof-of-Concept Trial with Erlotinib.

01-04-2022

Clinical cancer research : an official journal of the American Association for Cancer Research

Patients with Rare Cancers in the Drug Rediscovery Protocol (DRUP) Benefit from Genomics-Guided Treatment.

01-04-2022

The Lancet. Oncology

Toxicity and efficacy of chronomodulated chemotherapy: a systematic review.

01-03-2022

European journal of cancer (Oxford, England : 1990)

Clinical pharmacology of cytotoxic drugs in neonates and infants: Providing evidence-based dosing guidance.

01-03-2022

Clinical and experimental rheumatology

Is there a potential for therapeutic drug monitoring of subcutaneously administered tocilizumab in patients with rheumatoid arthritis in daily practice?

01-03-2022