Publications

Nature

The Drug Rediscovery protocol facilitates the expanded use of existing anticancer drugs.

01-10-2019

Key

Journal of pharmaceutical and biomedical analysis

A multiplex UPLC-MS/MS method for the quantification of three PD-L1 checkpoint inhibitors, atezolizumab, avelumab, and durvalumab, in human serum.

15-06-2024

EJNMMI radiopharmacy and chemistry

Automated radiolabelling of [⁶⁸Ga]Ga-PSMA-11 (gallium (⁶⁸Ga)-gozetotide) using the Locametz® kit and two generators.

17-04-2024

Pharmaceutical research

Pharmacokinetics of PEGasparaginase in Infants with Acute Lymphoblastic Leukemia.

01-04-2024

European journal of cancer (Oxford, England : 1990)

Propranolol monotherapy in angiosarcoma - A window-of-opportunity study (PropAngio).

02-03-2024

Cancer chemotherapy and pharmacology

Impact of bariatric surgery on oral anticancer drugs: an analysis of real-world data.

01-03-2024

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Bosutinib in Resistant and Intolerant Pediatric Patients With Chronic Phase Chronic Myeloid Leukemia: Results From the Phase I Part of Study ITCC054/COG AAML1921.

01-03-2024

Cytotherapy

High-dose individualized antithymocyte globulin with therapeutic drug monitoring in high-risk cord blood transplant.

23-02-2024

European journal of nuclear medicine and molecular imaging

The cycle effect quantified: reduced tumour uptake in subsequent cycles of [¹⁷⁷Lu]Lu-HA-DOTATATE during peptide receptor radionuclide therapy.

01-02-2024

Cancer chemotherapy and pharmacology

Are novel oral oncolytics underdosed in obese patients?

01-02-2024

Journal of clinical pharmacology

Is Higher Docetaxel Clearance in Prostate Cancer Patients Explained by Higher CYP3A? An In Vivo Phenotyping Study with Midazolam.

01-02-2024

Therapeutic drug monitoring

Clinical Relevance of High Plasma Trough Levels of the Kinase Inhibitors Crizotinib, Alectinib, Osimertinib, Dabrafenib, and Trametinib in NSCLC Patients.

01-02-2024

Therapeutic drug monitoring

Analytical Validation of a Volumetric Absorptive Microsampling Method for Therapeutic Drug Monitoring of the Oral Targeted Anticancer Agents, Abiraterone, Alectinib, Cabozantinib, Imatinib, Olaparib, and Sunitinib, and Metabolites.

30-01-2024

Therapeutic drug monitoring

Tocilizumab Dose Tapering Based on a Model-Based Algorithm is Feasible in Clinical Practice: A Short Communication.

24-01-2024

Clinical and translational science

Predictability of human exposure by human-CYP3A4-transgenic mouse models: A meta-analysis.

01-01-2024

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

A common germline variant in CYP11B1 is associated with adverse clinical outcome of treatment with abiraterone or enzalutamide.

31-12-2023

Clinical and translational science

The use of microtracers in food-effect trials: An alternative study design for toxic drugs with long half-lives exemplified by the case for alectinib.

01-12-2023

CPT: pharmacometrics & systems pharmacology

Physiologically-based pharmacokinetic model to predict doxorubicin and paclitaxel exposure in infants through breast milk.

01-12-2023

Pharmaceutical research

Cortisol as Biomarker for CYP17-Inhibition is Associated with Therapy Outcome of Abiraterone Acetate.

01-12-2023

The New England journal of medicine

Severe Immune-Related Enteritis after In Utero Exposure to Pembrolizumab.

09-11-2023

The Journal of antimicrobial chemotherapy

Population pharmacokinetics of a combination of miltefosine and paromomycin in Eastern African children and adults with visceral leishmaniasis.

06-11-2023

European journal of cancer (Oxford, England : 1990)

Pharmacokinetic boosting of olaparib: A randomised, cross-over study (PROACTIVE-study).

01-11-2023

Paediatric drugs

Azacitidine (Vidaza^®) in Pediatric Patients with Relapsed Advanced MDS and JMML: Results of a Phase I/II Study by the ITCC Consortium and the EWOG-MDS Group (Study ITCC-015).

01-11-2023

Therapeutic drug monitoring

Potential of Mesalazine Therapeutic Drug Monitoring by Measuring Fecal Excretion in Patients With Ulcerative Colitis.

01-10-2023

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

High accumulation of nivolumab in human breast milk: A case report.

01-10-2023

British journal of clinical pharmacology

Optimizing carboplatin dosing by an improved prediction of carboplatin clearance using a CT-enhanced estimate of renal function.

01-10-2023

Obesity surgery

Impact of Bariatric Surgery in the Short and Long Term: A Need for Time-Dependent Dosing of Drugs.

01-10-2023

Clinical pharmacokinetics

Therapeutic Drug Monitoring of Kinase Inhibitors in Oncology.

01-10-2023

EJNMMI physics

Predicting [¹⁷⁷Lu]Lu-HA-DOTATATE kidney and tumor accumulation based on [⁶⁸Ga]Ga-HA-DOTATATE diagnostic imaging using semi-physiological population pharmacokinetic modeling.

24-08-2023

Clinical pharmacokinetics

Semi-physiological Enriched Population Pharmacokinetic Modelling to Predict the Effects of Pregnancy on the Pharmacokinetics of Cytotoxic Drugs.

01-08-2023

CPT: pharmacometrics & systems pharmacology

Population pharmacokinetic dosimetry model using imaging data to assess variability in pharmacokinetics of ¹⁷⁷ Lu-PSMA-617 in prostate cancer patients.

01-08-2023

Clinical pharmacokinetics

CYP3A4*22 Genotype-Guided Dosing of Kinase Inhibitors in Cancer Patients.

01-08-2023

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Design and statistics of pharmacokinetic drug-drug, herb-drug, and food-drug interaction studies in oncology patients.

01-07-2023

Gynecologic oncology

WEE1 inhibitor adavosertib in combination with carboplatin in advanced TP53 mutated ovarian cancer: A biomarker-enriched phase II study.

01-07-2023

Clinical pharmacokinetics

Predicting Chemotherapy Distribution into Breast Milk for Breastfeeding Women Using a Population Pharmacokinetic Approach.

01-07-2023

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

Genetic variants found in paediatric oncology patients with severe chemotherapy-induced toxicity: A case series.

01-07-2023

EJNMMI research

Predicting the effect of different folate doses on [⁶⁸Ga]Ga-PSMA-11 organ and tumor uptake using physiologically based pharmacokinetic modeling.

15-06-2023

Cancer chemotherapy and pharmacology

Exposure-response analyses of BRAF- and MEK-inhibitors dabrafenib plus trametinib in melanoma patients.

01-06-2023

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

A simple extemporaneous oral suspension of aprepitant yields sufficient pharmacokinetic exposure in children.

01-06-2023

Therapeutic drug monitoring

Development of a Therapeutic Drug Monitoring Strategy for the Optimization of Vincristine Treatment in Pediatric Oncology Populations in Africa.

01-06-2023

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Ion suppression, reduced long-term robustness and leakage current of the spray voltage during the ionization of trichloroacetic acid; a case study with a methylmalonic acid assay.

30-05-2023

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

Redispensing of expensive oral anticancer medicines: A practical application.

16-05-2023

Pharmaceutics

Optimization of a Quantitative Anti-Drug Antibodies against Infliximab Assay with the Liquid Chromatography-Tandem Mass Spectrometry: A Method Validation Study and Future Perspectives.

12-05-2023

EClinicalMedicine

Influence of germline variations in drug transporters ABCB1 and ABCG2 on intracerebral osimertinib efficacy in patients with non-small cell lung cancer.

01-05-2023

Pharmaceutical research

Exposure-Response Analyses of Olaparib in Real-Life Patients with Ovarian Cancer.

01-05-2023

Journal of controlled release : official journal of the Controlled Release Society

Radiosensitisation by olaparib through focused ultrasound delivery in a diffuse midline glioma model.

01-05-2023

Haematologica

Combination therapy with crizotinib and vinblastine for relapsed or refractory pediatric ALK-positive anaplastic large cell lymphoma.

01-05-2023

Cancer treatment reviews

Clinical development of WEE1 inhibitors in gynecological cancers: A systematic review.

01-04-2023

Frontiers in oncology

Therapeutic drug monitoring guided dosing versus standard dosing of alectinib in advanced ALK positive non-small cell lung cancer patients: Study protocol for an international, multicenter phase IV randomized controlled trial (ADAPT ALEC).

28-03-2023

Journal of pharmaceutical and biomedical analysis

A sensitive liquid chromatographic-mass spectrometry method for the quantification of vincristine in whole blood collected with volumetric absorptive microsampling.

20-02-2023