Publications

Anti-cancer drugs

Phase I and pharmacologic study of weekly doxorubicin and 1 h infusional paclitaxel in patients with advanced breast cancer.

01-09-1998

Journal of chromatography. B, Biomedical sciences and applications

Determination of doxorubicin and metabolites in murine specimens by high-performance liquid chromatography.

07-08-1998

Pharmacological research

The pharmacological role of P-glycoprotein in the intestinal epithelium.

01-06-1998

Cancer research

Comparative pharmacology of the novel cyclopropylpyrroloindole-prodrug carzelesin in mice, rats, and humans.

01-06-1998

Cancer chemotherapy and pharmacology

A clinical pharmacokinetics study of carzelesin given by short-term intravenous infusion in a phase I study.

02-04-1998

European journal of cancer (Oxford, England : 1990)

Intraperitoneal cisplatin with regional hyperthermia in advanced ovarian cancer: pharmacokinetics and cisplatin-DNA adduct formation in patients and ovarian cancer cell lines.

01-01-1998

Journal of pharmaceutical sciences

The functional role of P-glycoprotein in the blood-brain barrier.

01-08-1997

Proceedings of the National Academy of Sciences of the United States of America

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins.

15-04-1997

Proceedings of the National Academy of Sciences of the United States of America

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine.

04-03-1997

Cancer chemotherapy and pharmacology

The vascular compartment hampers accurate determination of teniposide penetration into brain tumor tissue.

01-01-1997

British journal of cancer

Enhanced oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833.

01-01-1997

Journal of the National Cancer Institute

Altered pharmacokinetics of vinblastine in Mdr1a P-glycoprotein-deficient Mice.

17-07-1996

Journal of chromatography. B, Biomedical applications

Determination of polyoxyethyleneglycerol triricinoleate 35 (Cremophor EL) in plasma by pre-column derivatization and reversed-phase high-performance liquid chromatography.

07-06-1996

Drug metabolism and disposition: the biological fate of chemicals

Isolation, purification and biological activity of major docetaxel metabolites from human feces.

01-06-1996

Cancer research

Nonlinear pharmacokinetics of paclitaxel in mice results from the pharmaceutical vehicle Cremophor EL.

01-05-1996

Cancer chemotherapy and pharmacology

Unchanged pharmacokinetics of etoposide given by intra-arterial hepatic infusion as compared with i.v. infusion.

01-01-1996

Anti-cancer drugs

Tissue distribution, metabolism and excretion of paclitaxel in mice.

01-01-1996

Journal of chromatography. B, Biomedical applications

Quantification of paclitaxel metabolites in human plasma by high-performance liquid chromatography.

15-12-1995

Journal of pharmaceutical and biomedical analysis

High-performance liquid chromatographic analysis of the new antitumour drug N-benzoylstaurosporine (CGP 41 251) and four potential metabolites in micro-volumes of plasma.

01-12-1995

Therapeutic drug monitoring

Monitoring carboplatin concentrations in saliva: a replacement for plasma ultrafiltrate measurements?

01-10-1995

Proceedings of the National Academy of Sciences of the United States of America

Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein.

15-08-1995

Cancer chemotherapy and pharmacology

Isolation, purification, and biological activity of mono- and dihydroxylated paclitaxel metabolites from human feces.

01-01-1995

Pharmacy world & science : PWS

Bioanalysis and pharmacokinetics of (investigational) vinca alkaloids.

10-06-1994

Cell

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs.

20-05-1994

Journal of chromatography

Fully automated high-performance liquid chromatographic method for the determination of carzelesin (U-80,244) and metabolites (U-76,073 and U-76,074) in human plasma.

14-01-1994

Cancer chemotherapy and pharmacology

Validation of a limited sampling model for carboplatin in a high-dose chemotherapy combination.

01-01-1994

Cancer chemotherapy and pharmacology

The pharmacokinetics of reduced folates after intraperitoneal and intravenous administration of racemic [6S,R]-folinic acid.

01-01-1994

Cancer chemotherapy and pharmacology

Plasma pharmacokinetics, tissue disposition, excretion and metabolism of vinleucinol in mice as determined by high-performance liquid chromatography.

01-01-1994

Journal of pharmaceutical and biomedical analysis

Chemical stability of the new antitumour agent intoplicine in infusion fluids.

01-11-1993

Investigational new drugs

Plasma pharmacokinetics, tissue disposition, excretion and metabolism of vinorelbine in mice as determined by high performance liquid chromatography.

01-05-1993

Cancer research

Plasma pharmacokinetics of vinblastine and the investigational Vinca alkaloid N-(deacetyl-O-4-vinblastoyl-23)-L-ethyl isoleucinate in mice as determined by high-performance liquid chromatography.

01-05-1993

Cancer chemotherapy and pharmacology

Tissue disposition, excretion and metabolism of vinblastine in mice as determined by high-performance liquid chromatography.

01-01-1993

Anticancer research

Pharmacology, bio-analysis and pharmacokinetics of the vinca alkaloids and semi-synthetic derivatives (review).

01-09-1992

Journal of chromatography

Bioanalysis of the investigational anti-tumour drug 5,10-dideaza-5,6,7,8-tetrahydrofolic acid by high-performance liquid chromatography with ultraviolet detection.

15-04-1992

Journal of chromatography

Biodetermination of N-(deacetyl-O-4-vinblastoyl-23)-L-tryptophan, a metabolite of vintriptol, by high-performance liquid chromatography with fluorescence detection.

14-02-1992

Journal of chromatography

Bio-analysis of vinorelbine by high-performance liquid chromatography with fluorescence detection.

17-01-1992

Journal of chromatography

High-performance liquid chromatographic determination of vinblastine, 4-O-deacetylvinblastine and the potential metabolite 4-O-deacetylvinblastine-3-oic acid in biological fluids.

16-08-1991

Cancer chemotherapy and pharmacology

Antibodies against cisplatin-modified DNA and cisplatin-modified (di)nucleotides.

01-01-1991

Journal of pharmaceutical and biomedical analysis

Analytical methods for the determination of vinca alkaloids in biological specimens: a survey of the literature.

01-01-1991

European journal of cancer (Oxford, England : 1990)

Phase I study of vintriptol, a tryptophan ester of vinblastine.

01-01-1991

Cancer chemotherapy and pharmacology

Intratumoural administration of cisplatin in slow-release devices: II. Pharmacokinetics and intratumoural distribution.

01-01-1991

Journal of chromatography

High-performance liquid chromatographic bio-analysis and preliminary pharmacokinetics of the experimental antitumour drug vintriptol.

03-08-1990

Journal of chromatography

High-performance liquid chromatographic method for the analysis of 10-ethyl-10-deaza-aminopterin and metabolites in plasma.

13-07-1990

Journal of pharmaceutical and biomedical analysis

Bio-analysis of N-(deacetyl-O-4-vinblastoyl-23)-L-ethyl isoleucinate, methane sulphonate (VileE) by high-performance liquid chromatography with fluorescence detection.

01-01-1990

Journal of chromatography

Stable and sensitive method for the simultaneous determination of N5-methyltetrahydrofolate, leucovorin, methotrexate and 7-hydroxymethotrexate in biological fluids.

24-03-1989

Clinica chimica acta; international journal of clinical chemistry

Improved method for the quantification of aminoglutethimide in urine samples.

30-10-1987