Immune response to DCIS. The various types of immune cells are indicated by different colours, such as green, magenta, and red. DCIS is seen in the upper left part, indicated by the greyish cell borders.

Immune response to DCIS. The various types of immune cells are indicated by different colours, such as green, magenta, and red. DCIS is seen in the upper left part, indicated by the greyish cell borders.

Jelle Wesseling

Predict outcome of DCIS and breast cancer

Jelle Wesseling’s overarching research focus is to develop new strategies to substantially improve the prognostic and predictive power of breast cancer pathology and to understand the underlying biology. Ultimately, he aims to define with high accuracy who to treat, how to treat and, if so, for what benefit and so achieve the best benefit-to-harm ratio for women with DCIS and IBC.

More about this group

Our research

Team members

Wesseling Profiel
Jelle Wesseling

Group leader
Proteeti
Proteeti Bhattacharjee

Scientific project manager
Will Harley
Will Harley

PhD student
Petra Kristel
Petra Kristel

Technician
Esther Lips
Esther Lips

Associate staff scientist
Lennart Mulder
Lennart Mulder

Technician
Lot Mulder
Lot Mulder

PhD student
Margot Nieberg
Margot Nieberg

PhD student
Marek Oerlemans
Marek Oerlemans

PhD student
Renée Schmitz
Renée Schmitz

PhD student
Sandra Van Den Belt Dusebout
Sandra van den Belt-Dusebout

Postdoctoral fellow
Merle van Leeuwen
Merle van Leeuwen

PhD student
545644 Weiner 2
Julian Weiner

PhD student
Leon Wils
Leon Wils

Postdoctoral fellow

Alumni

Sena Alaeikhanehshir
Marte Liefaard
Maartje van Seijen
Marcelo Sobral-Leite

News and stories from this group

Microscopy image of DCIS tissue sample with ERBB2 amplified via ecDNA

Decoding DCIS: whole-genome sequencing reveals early DNA changes linked to breast cancer risk

11-06-2026
Groepsfoto ECD 20250514 2 Crop

First NKI Early Cancer Detection Conference turns out a success

19-05-2025
Example DCIS 1

High impact review reveals global paradigm shift in management of DCIS

10-05-2024
DCIS Figure 2 Lips

New technique to study pre-invasive breast cancer

16-08-2023

Publications of this group

British journal of cancer

Comprehensive multiplexed immune profiling of the ductal carcinoma in situ immune microenvironment regarding subsequent ipsilateral invasive breast cancer risk.

01-10-2022
Key Publication

Nature genetics

Genomic analysis defines clonal relationships of ductal carcinoma in situ and recurrent invasive breast cancer.

01-06-2022
Key Publication

NPJ breast cancer

Comprehensive characterization of pre- and post-treatment samples of breast cancer reveal potential mechanisms of chemotherapy resistance.

06-05-2022
Key Publication

The American journal of surgical pathology

Discordant Marker Expression Between Invasive Breast Carcinoma and Corresponding Synchronous and Preceding DCIS.

01-11-2019
Key Publication

British journal of cancer

Ductal carcinoma in situ: to treat or not to treat, that is the question.

01-08-2019
Key Publication

Clinical cancer research : an official journal of the American Association for Cancer Research

Clinicopathological Risk Factors for an Invasive Breast Cancer Recurrence after Ductal Carcinoma In Situ-A Nested Case-Control Study.

01-08-2018
Key Publication
More publications

Our collaborations

Microscopic image of human Ductal Carcinoma In Situ (Green) tumor cells growing inside the mammary duct

Jos Jonkers
Abstract depiction of network reconstruction from data

Lodewyk Wessels

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547818 Uitterhoeve
Danielle Uitterhoeve

Office Manager

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NKI Placeholder Profiel
Marja van Rijn

Persoonlijk Assistent

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