There are two areas of interest of my group: Genomics-guided precision medicine and precision medicine guided by tumor organoids.
To perform impactful research my group consists of a multidisciplinary, international team of biologists, computational scientists and clinicians.
Not all cancer cells within a tumor are the same. They differ in their evolutionary history, and these differences can determine whether the immune system can recognize them. That is the key finding of our recently published study in Cancer Cell, made possible through the use of advanced organoid co-culture models that allowed functionally determining the extent of immune control at single subclone resolution. The results offer a possible explanation for why immunotherapy often fails to eliminate the whole tumor.
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