Hoencamp et al., Science, 2021
In an incredible collaboration with the labs of Erez Lieberman Aiden, Jose Onuchic, Michele di Pierro, multiple NKI-based groups, and the DNA Zoo consortium, we study chromosome-scale genome folding across the eukaryotic tree of life. The absence of condensin II subunits turns out to correlate with the type of nuclear architecture. Depletion of condensin II in human cells transforms the folding of the human genome into a state as found in mosquitoes and fungi.
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