Publications

Cell reports

Functional Radiogenetic Profiling Implicates ERCC6L2 in Non-homologous End Joining.

25-08-2020

Proceedings of the National Academy of Sciences of the United States of America

The histone methyltransferase DOT1L prevents antigen-independent differentiation and safeguards epigenetic identity of CD8⁺ T cells.

25-08-2020

BMC cancer

Circulating tumor DNA guided adjuvant chemotherapy in stage II colon cancer (MEDOCC-CrEATE): study protocol for a trial within a cohort study.

20-08-2020

BMC cancer

Improving clinical management of colon cancer through CONNECTION, a nation-wide colon cancer registry and stratification effort (CONNECTION II trial): rationale and protocol of a single arm intervention study.

18-08-2020

International journal of cancer

A prospective observational registry evaluating clinical outcomes of Radium-223 treatment in a nonstudy population.

15-08-2020

Toxicology and applied pharmacology

Human organic anion transporting polypeptide (OATP) 1B3 and mouse OATP1A/1B affect liver accumulation of Ochratoxin A in mice.

15-08-2020

Clinical cancer research : an official journal of the American Association for Cancer Research

The Outcome of Ex Vivo TIL Expansion Is Highly Influenced by Spatial Heterogeneity of the Tumor T-Cell Repertoire and Differences in Intrinsic In Vitro Growth Capacity between T-Cell Clones.

15-08-2020

International journal of cancer

EORTC SPECTA-AYA: A unique molecular profiling platform for adolescents and young adults with cancer in Europe.

15-08-2020

Biology open

Comparative interactomics analysis reveals potential regulators of α6β4 distribution in keratinocytes.

13-08-2020

Cancers

Neoadjuvant Systemic Treatment of Primary Angiosarcoma.

12-08-2020

Sarcoma

Assessing the Desmoid-Type Fibromatosis Patients' Voice: Comparison of Health-Related Quality of Life Experiences from Patients of Two Countries.

11-08-2020

Breast cancer research : BCR

Targetable ERBB2 mutation status is an independent marker of adverse prognosis in estrogen receptor positive, ERBB2 non-amplified primary lobular breast carcinoma: a retrospective in silico analysis of public datasets.

11-08-2020

Nature communications

Reversal of pre-existing NGFR-driven tumor and immune therapy resistance.

07-08-2020

EJNMMI research

A DROP-IN beta probe for robot-assisted ⁶⁸Ga-PSMA radioguided surgery: first ex vivo technology evaluation using prostate cancer specimens.

06-08-2020

Brachytherapy

Applicator visualization using ultrashort echo time MRI for high-dose-rate endorectal brachytherapy.

05-08-2020

European journal of clinical pharmacology

Determination of the absolute bioavailability of oral imatinib using a stable isotopically labeled intravenous imatinib-d8 microdose.

01-08-2020

Clinical psychology review

Effects and moderators of coping skills training on symptoms of depression and anxiety in patients with cancer: Aggregate data and individual patient data meta-analyses.

01-08-2020

Investigational new drugs

Mass balance and metabolite profiling of ¹⁴C-guadecitabine in patients with advanced cancer.

01-08-2020

Pharmacology research & perspectives

No relation between docetaxel administration route and high-grade diarrhea incidence.

01-08-2020

European journal of cancer (Oxford, England : 1990)

Adjuvant chemotherapy in small node-negative triple-negative breast cancer.

01-08-2020

Radiology

Radiogenomic Analysis of Breast Cancer by Linking MRI Phenotypes with Tumor Gene Expression.

01-08-2020

Acta oncologica (Stockholm, Sweden)

First system for fully-automated multi-criterial treatment planning for a high-magnetic field MR-Linac applied to rectal cancer.

01-08-2020

Annals of oncology : official journal of the European Society for Medical Oncology

Updated efficacy results from the JAVELIN Renal 101 trial: first-line avelumab plus axitinib versus sunitinib in patients with advanced renal cell carcinoma.

01-08-2020

Thyroid : official journal of the American Thyroid Association

Long-Term Effects of Radioiodine Treatment on Female Fertility in Survivors of Childhood Differentiated Thyroid Carcinoma.

01-08-2020

International journal of cancer

Ascertainment of cancer in longitudinal research: The concordance between the Rotterdam Study and the Netherlands Cancer Registry.

01-08-2020

Cancer

Patterns and predictors of cancer-related fatigue in ovarian and endometrial cancers: 1-year longitudinal study.

01-08-2020

Journal for immunotherapy of cancer

Rationalizing the pathway to personalized neoadjuvant immunotherapy: the Lombard Street Approach.

01-08-2020

Annals of oncology : official journal of the European Society for Medical Oncology

Management of early melanoma recurrence despite adjuvant anti-PD-1 antibody therapy^☆.

01-08-2020

British journal of clinical pharmacology

A semi-mechanistic model based on glutathione depletion to describe intra-individual reduction in busulfan clearance.

01-08-2020

Molecular oncology

Towards a cancer mission in Horizon Europe: recommendations.

01-08-2020

Journal for immunotherapy of cancer

Tumor infiltrating lymphocytes (TIL) therapy in metastatic melanoma: boosting of neoantigen-specific T cell reactivity and long-term follow-up.

01-08-2020

The Lancet. Oncology

100 European core quality standards for cancer care and research centres.

01-08-2020

Acta oncologica (Stockholm, Sweden)

Health-related quality of life and symptom burden of epithelioid hemangioendothelioma patients: a global patient-driven Facebook study in a very rare malignancy.

01-08-2020

European urology oncology

Distribution of Molecular Subtypes in Muscle-invasive Bladder Cancer Is Driven by Sex-specific Differences.

01-08-2020

Nature genetics

The DNA methylation landscape of advanced prostate cancer.

01-08-2020

Annals of surgical oncology

Selection of Patients for Organ Preservation After Chemoradiotherapy: MRI Identifies Poor Responders Who Can Go Straight to Surgery.

01-08-2020

Genes & development

Cells of origin of lung cancers: lessons from mouse studies.

01-08-2020

Investigational new drugs

Phase I study of intermittent olaparib capsule or tablet dosing in combination with carboplatin and paclitaxel (part 2).

01-08-2020

Therapeutic drug monitoring

Evaluation of Extrapolation Methods to Predict Trough Concentrations to Guide Therapeutic Drug Monitoring of Oral Anticancer Drugs.

01-08-2020

Head & neck

Long-term swallowing, trismus, and speech outcomes after combined chemoradiotherapy and preventive rehabilitation for head and neck cancer; 10-year plus update.

01-08-2020

International journal of epidemiology

A Mendelian randomization analysis of circulating lipid traits and breast cancer risk.

01-08-2020

Breast (Edinburgh, Scotland)

The impact of menstruation persistence or recovery after chemotherapy on survival in young patients with hormone receptor negative breast cancer.

01-08-2020

Nature reviews. Immunology

Immune crosstalk in cancer progression and metastatic spread: a complex conversation.

01-08-2020

European journal of human genetics : EJHG

The uptake of predictive DNA testing in 40 families with a pathogenic BRCA1/BRCA2 variant. An evaluation of the proband-mediated procedure.

01-08-2020

Investigational new drugs

Phase I study of continuous olaparib capsule dosing in combination with carboplatin and/or paclitaxel (Part 1).

01-08-2020

Journal of medical genetics

Variants of uncertain clinical significance in hereditary breast and ovarian cancer genes: best practices in functional analysis for clinical annotation.

01-08-2020

Nature genetics

Prostate cancer reactivates developmental epigenomic programs during metastatic progression.

01-08-2020

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Feasibility of cone beam CT-guided library of plans strategy in pre-operative gastric cancer radiotherapy.

01-08-2020

Nucleosides, nucleotides & nucleic acids

Effect of dexamethasone on the antileukemic effect of cytarabine: role of deoxycytidine kinase.

31-07-2020

BMC cancer

Evaluating different adoption scenarios for TIL-therapy and the influence on its (early) cost-effectiveness.

31-07-2020

Functional Radiogenetic Profiling Implicates ERCC6L2 in Non-homologous End Joining.

The histone methyltransferase DOT1L prevents antigen-independent differentiation and safeguards epigenetic identity of CD8+ T cells.

Circulating tumor DNA guided adjuvant chemotherapy in stage II colon cancer (MEDOCC-CrEATE): study protocol for a trial within a cohort study.

Improving clinical management of colon cancer through CONNECTION, a nation-wide colon cancer registry and stratification effort (CONNECTION II trial): rationale and protocol of a single arm intervention study.

A prospective observational registry evaluating clinical outcomes of Radium-223 treatment in a nonstudy population.

Human organic anion transporting polypeptide (OATP) 1B3 and mouse OATP1A/1B affect liver accumulation of Ochratoxin A in mice.

The Outcome of Ex Vivo TIL Expansion Is Highly Influenced by Spatial Heterogeneity of the Tumor T-Cell Repertoire and Differences in Intrinsic In Vitro Growth Capacity between T-Cell Clones.

EORTC SPECTA-AYA: A unique molecular profiling platform for adolescents and young adults with cancer in Europe.

Comparative interactomics analysis reveals potential regulators of α6β4 distribution in keratinocytes.

Neoadjuvant Systemic Treatment of Primary Angiosarcoma.

Assessing the Desmoid-Type Fibromatosis Patients' Voice: Comparison of Health-Related Quality of Life Experiences from Patients of Two Countries.

Targetable ERBB2 mutation status is an independent marker of adverse prognosis in estrogen receptor positive, ERBB2 non-amplified primary lobular breast carcinoma: a retrospective in silico analysis of public datasets.

Reversal of pre-existing NGFR-driven tumor and immune therapy resistance.

A DROP-IN beta probe for robot-assisted 68Ga-PSMA radioguided surgery: first ex vivo technology evaluation using prostate cancer specimens.

Applicator visualization using ultrashort echo time MRI for high-dose-rate endorectal brachytherapy.

Determination of the absolute bioavailability of oral imatinib using a stable isotopically labeled intravenous imatinib-d8 microdose.

Effects and moderators of coping skills training on symptoms of depression and anxiety in patients with cancer: Aggregate data and individual patient data meta-analyses.

Mass balance and metabolite profiling of 14C-guadecitabine in patients with advanced cancer.

No relation between docetaxel administration route and high-grade diarrhea incidence.

Adjuvant chemotherapy in small node-negative triple-negative breast cancer.

Radiogenomic Analysis of Breast Cancer by Linking MRI Phenotypes with Tumor Gene Expression.

First system for fully-automated multi-criterial treatment planning for a high-magnetic field MR-Linac applied to rectal cancer.

Updated efficacy results from the JAVELIN Renal 101 trial: first-line avelumab plus axitinib versus sunitinib in patients with advanced renal cell carcinoma.

Long-Term Effects of Radioiodine Treatment on Female Fertility in Survivors of Childhood Differentiated Thyroid Carcinoma.

Ascertainment of cancer in longitudinal research: The concordance between the Rotterdam Study and the Netherlands Cancer Registry.

Patterns and predictors of cancer-related fatigue in ovarian and endometrial cancers: 1-year longitudinal study.

Rationalizing the pathway to personalized neoadjuvant immunotherapy: the Lombard Street Approach.

Management of early melanoma recurrence despite adjuvant anti-PD-1 antibody therapy☆.

A semi-mechanistic model based on glutathione depletion to describe intra-individual reduction in busulfan clearance.

Towards a cancer mission in Horizon Europe: recommendations.

Tumor infiltrating lymphocytes (TIL) therapy in metastatic melanoma: boosting of neoantigen-specific T cell reactivity and long-term follow-up.

100 European core quality standards for cancer care and research centres.

Health-related quality of life and symptom burden of epithelioid hemangioendothelioma patients: a global patient-driven Facebook study in a very rare malignancy.

Distribution of Molecular Subtypes in Muscle-invasive Bladder Cancer Is Driven by Sex-specific Differences.

The DNA methylation landscape of advanced prostate cancer.

Selection of Patients for Organ Preservation After Chemoradiotherapy: MRI Identifies Poor Responders Who Can Go Straight to Surgery.

Cells of origin of lung cancers: lessons from mouse studies.

Phase I study of intermittent olaparib capsule or tablet dosing in combination with carboplatin and paclitaxel (part 2).

Evaluation of Extrapolation Methods to Predict Trough Concentrations to Guide Therapeutic Drug Monitoring of Oral Anticancer Drugs.

Long-term swallowing, trismus, and speech outcomes after combined chemoradiotherapy and preventive rehabilitation for head and neck cancer; 10-year plus update.

A Mendelian randomization analysis of circulating lipid traits and breast cancer risk.

The impact of menstruation persistence or recovery after chemotherapy on survival in young patients with hormone receptor negative breast cancer.

Immune crosstalk in cancer progression and metastatic spread: a complex conversation.

The uptake of predictive DNA testing in 40 families with a pathogenic BRCA1/BRCA2 variant. An evaluation of the proband-mediated procedure.

Phase I study of continuous olaparib capsule dosing in combination with carboplatin and/or paclitaxel (Part 1).

Variants of uncertain clinical significance in hereditary breast and ovarian cancer genes: best practices in functional analysis for clinical annotation.

Prostate cancer reactivates developmental epigenomic programs during metastatic progression.

Feasibility of cone beam CT-guided library of plans strategy in pre-operative gastric cancer radiotherapy.

Effect of dexamethasone on the antileukemic effect of cytarabine: role of deoxycytidine kinase.

Evaluating different adoption scenarios for TIL-therapy and the influence on its (early) cost-effectiveness.

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The histone methyltransferase DOT1L prevents antigen-independent differentiation and safeguards epigenetic identity of CD8⁺ T cells.

A DROP-IN beta probe for robot-assisted ⁶⁸Ga-PSMA radioguided surgery: first ex vivo technology evaluation using prostate cancer specimens.

Mass balance and metabolite profiling of ¹⁴C-guadecitabine in patients with advanced cancer.

Management of early melanoma recurrence despite adjuvant anti-PD-1 antibody therapy^☆.