Publications

Proteins

Structure of human CLIC3 at 2 A resolution.

British journal of clinical pharmacology

Population pharmacokinetics of intravenously and orally administered docetaxel with or without co-administration of ritonavir in patients with advanced cancer.

Clinical genetics

Psychosocial impact of Von Hippel-Lindau disease: levels and sources of distress.

European journal of cancer (Oxford, England : 1990)

Cost-effectiveness of the 70-gene signature versus St. Gallen guidelines and Adjuvant Online for early breast cancer.

Cancer

Intra-arterial versus intravenous chemoradiation for advanced head and neck cancer: Results of a randomized phase 3 trial.

Nature medicine

Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy.

The Journal of biological chemistry

Magnesium coordination controls the molecular switch function of DNA mismatch repair protein MutS.

23-04-2010

BMC genomics

Major role for mRNA stability in shaping the kinetics of gene induction.

21-04-2010

Proceedings of the National Academy of Sciences of the United States of America

Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation.

20-04-2010

BMC genomics

Small RNA expression and strain specificity in the rat.

19-04-2010

Journal of cell science

The hinge region of the human estrogen receptor determines functional synergy between AF-1 and AF-2 in the quantitative response to estradiol and tamoxifen.

15-04-2010

Cell

Drugging drug resistance.

02-04-2010

Cell

It's diagnostics, stupid.

02-04-2010

Seminars in radiation oncology

Adaptive radiotherapy for lung cancer.

Breast cancer research and treatment

The predictive value of the 70-gene signature for adjuvant chemotherapy in early breast cancer.

Psycho-oncology

The impact of different definitions and reference groups on the prevalence of cognitive impairment: a study in postmenopausal breast cancer patients before the start of adjuvant systemic therapy.

Annals of surgery

MRI-model to guide the surgical treatment in breast cancer patients after neoadjuvant chemotherapy.

Molecular cancer research : MCR

Interleukin-1R-associated kinase 2 is a novel modulator of the transforming growth factor beta signaling cascade.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

The role of FDG PET/CT in patients with locoregional breast cancer recurrence: a comparison to conventional imaging techniques.

Annals of oncology : official journal of the European Society for Medical Oncology

The 70-gene prognosis signature predicts early metastasis in breast cancer patients between 55 and 70 years of age.

Investigational new drugs

Disposition and toxicity of trabectedin (ET-743) in wild-type and mdr1 gene (P-gp) knock-out mice.

Molecular pharmacology

Hepatic clearance of reactive glucuronide metabolites of diclofenac in the mouse is dependent on multiple ATP-binding cassette efflux transporters.

European journal of clinical investigation

microRNAs, RNA binding proteins and cancer.

Molecular imaging and biology

Predicting early chemotherapy response with technetium-99m methoxyisobutylisonitrile SPECT/CT in advanced non-small cell lung cancer.

Nature cell biology

BRD7 is a candidate tumour suppressor gene required for p53 function.

Investigational new drugs

Dose-finding and pharmacokinetic study of orally administered indibulin (D-24851) to patients with advanced solid tumors.

European journal of cancer (Oxford, England : 1990)

Trends in incidence, treatment and survival of gastric adenocarcinoma between 1990 and 2007: a population-based study in the Netherlands.

Health and quality of life outcomes

Effects of mode of administration (MOA) on the measurement properties of the EORTC QLQ-C30: a randomized study.

30-03-2010

Cancer cell

PICS-ure this: prosenescence therapy?

16-03-2010

Urologia internationalis

Pim1 regulates androgen-dependent survival signaling in prostate cancer cells.

11-03-2010

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Effects of tamoxifen and exemestane on cognitive functioning of postmenopausal patients with breast cancer: results from the neuropsychological side study of the tamoxifen and exemestane adjuvant multinational trial.

10-03-2010

Psycho-oncology

Psychological distress and use of psychosocial support in familial adenomatous polyposis.

Oncology letters

Serum proteomics and disease-specific biomarkers of patients with advanced gastric cancer.

Cell death and differentiation

Radiation and anticancer drugs can facilitate mitochondrial bypass by CD95/Fas via c-FLIP downregulation.

Annals of oncology : official journal of the European Society for Medical Oncology

Postoperative chemoradiotherapy in gastric cancer--a phase I-II study of radiotherapy with dose escalation of weekly cisplatin and daily capecitabine chemotherapy.

AAPS PharmSciTech

Naked plasmid DNA formulation: effect of different disaccharides on stability after lyophilisation.

Annals of oncology : official journal of the European Society for Medical Oncology

A simple system for grading the response of breast cancer to neoadjuvant chemotherapy.

BJU international

Prostate cancer survivors who would be eligible for active surveillance but were either treated with radiotherapy or managed expectantly: comparisons on long-term quality of life and symptom burden.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Simultaneous quantification of emtricitabine and tenofovir nucleotides in peripheral blood mononuclear cells using weak anion-exchange liquid chromatography coupled with tandem mass spectrometry.

Annals of surgery

Prophylactic mastectomy in BRCA1 and BRCA2 mutation carriers: very low risk for subsequent breast cancer.

Nederlands tijdschrift voor geneeskunde

[Improved compliance with the 'Melanoma' treatment guideline].

23-02-2010

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy

Novel therapeutics in combination with radiotherapy to improve cancer treatment: rationale, mechanisms of action and clinical perspective.

20-02-2010

Cancer research

Sensitivity and acquired resistance of BRCA1;p53-deficient mouse mammary tumors to the topoisomerase I inhibitor topotecan.

15-02-2010

International journal of radiation oncology, biology, physics

Radiation-associated breast tumors display a distinct gene expression profile.

Carcinogenesis

Functional identification of LRF as an oncogene that bypasses RASV12-induced senescence via upregulation of CYCLIN E.

Molecular cancer therapeutics

Breast cancer resistance protein and P-glycoprotein limit sorafenib brain accumulation.

Genome research

Bayesian network analysis of targeting interactions in chromatin.