A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3).
Victor Enciso-Mora,
Peter Broderick,
Yussanne Ma,
Ruth F Jarrett,
Henrik Hjalgrim,
Kari Hemminki,
Anke van den Berg,
Bianca Olver,
Amy Lloyd,
Sara E Dobbins,
Tracy Lightfoot,
Flora E van Leeuwen,
Asta Försti,
Arjan Diepstra,
Annegien Broeks,
Jayaram Vijayakrishnan,
Lesley Shield,
Annette Lake,
Dorothy Montgomery,
Eve Roman,
Andreas Engert,
Elke Pogge von Strandmann,
Katrin S Reiners,
Ilja M Nolte,
Karin E Smedby,
Hans-Olov Adami,
Nicola S Russell,
Bengt Glimelius,
Stephen Hamilton-Dutoit,
Marieke de Bruin,
Lars P Ryder,
Daniel Molin,
Karina Meden Sorensen,
Ellen T Chang,
Malcolm Taylor,
Rosie Cooke,
Robert Hofstra,
Helga Westers,
Tom van Wezel,
Ronald van Eijk,
Alan Ashworth,
Klaus Rostgaard,
Mads Melbye,
Anthony J Swerdlow,
Richard S Houlston
Abstract
To identify susceptibility loci for classical Hodgkin's lymphoma (cHL), we conducted a genome-wide association study of 589 individuals with cHL (cases) and 5,199 controls with validation in four independent samples totaling 2,057 cases and 3,416 controls. We identified three new susceptibility loci at 2p16.1 (rs1432295, REL, odds ratio (OR) = 1.22, combined P = 1.91 × 10(-8)), 8q24.21 (rs2019960, PVT1, OR = 1.33, combined P = 1.26 × 10(-13)) and 10p14 (rs501764, GATA3, OR = 1.25, combined P = 7.05 × 10(-8)). Furthermore, we confirmed the role of the major histocompatibility complex in disease etiology by revealing a strong human leukocyte antigen (HLA) association (rs6903608, OR = 1.70, combined P = 2.84 × 10(-50)). These data provide new insight into the pathogenesis of cHL.