Publications

British journal of cancer

Long-term safety and anti-tumour activity of olaparib monotherapy after combination with carboplatin and paclitaxel in patients with advanced breast, ovarian or fallopian tube cancer.

28-07-2015

British journal of cancer

Are metformin, statin and aspirin use still associated with overall mortality among colorectal cancer patients with diabetes if adjusted for one another?

28-07-2015

Science translational medicine

Optimizing sharing of hospital biobank samples.

22-07-2015

International journal of clinical and experimental pathology

Down-regulation of OATP1B proteins correlates with hyperbilirubinemia in advanced cholestasis.

21-07-2015

Ecancermedicalscience

Staff perceptions of change resulting from participation in a European cancer accreditation programme: a snapshot from eight cancer centres.

17-07-2015

Genes & development

Origins, genetic landscape, and emerging therapies of small cell lung cancer.

15-07-2015

PloS one

Co-Orientation: Quantifying Simultaneous Co-Localization and Orientational Alignment of Filaments in Light Microscopy.

15-07-2015

Cancer cell

Mismatch Repair-Deficient Cancers Are Targets for Anti-PD-1 Therapy.

13-07-2015

eLife

MutS/MutL crystal structure reveals that the MutS sliding clamp loads MutL onto DNA.

11-07-2015

PloS one

Oncogenic Role of miR-15a-3p in 13q Amplicon-Driven Colorectal Adenoma-to-Carcinoma Progression.

07-07-2015

Proceedings of the National Academy of Sciences of the United States of America

Selective resistance to the PARP inhibitor olaparib in a mouse model for BRCA1-deficient metaplastic breast cancer.

07-07-2015

PloS one

Studying Hospitalizations and Mortality in the Netherlands: Feasible and Valid Using Two-Step Medical Record Linkage with Nationwide Registers.

07-07-2015

American journal of human genetics

Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate NRBF2 Expression.

02-07-2015

Nature

The core spliceosome as target and effector of non-canonical ATM signalling.

02-07-2015

BMC medicine

Annexin A1 expression in a pooled breast cancer series: association with tumor subtypes and prognosis.

02-07-2015

The New England journal of medicine

Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma.

02-07-2015

Journal of proteome research

Signal Transduction Reaction Monitoring Deciphers Site-Specific PI3K-mTOR/MAPK Pathway Dynamics in Oncogene-Induced Senescence.

02-07-2015

Pharmaceutical research

Brain and Testis Accumulation of Regorafenib is Restricted by Breast Cancer Resistance Protein (BCRP/ABCG2) and P-glycoprotein (P-GP/ABCB1).

01-07-2015

European journal of cancer (Oxford, England : 1990)

Treatment-related differences in health related quality of life and disease specific symptoms among colon cancer survivors: results from the population-based PROFILES registry.

01-07-2015

Cancer research

Hepatocellular Shuttling and Recirculation of Sorafenib-Glucuronide Is Dependent on Abcc2, Abcc3, and Oatp1a/1b.

01-07-2015

Clinical lung cancer

Concentrations of Erlotinib in Tumor Tissue and Plasma in Non-Small-Cell Lung Cancer Patients After Neoadjuvant Therapy.

01-07-2015

Trends in immunology

Assessing T lymphocyte function and differentiation by genetically encoded reporter systems.

01-07-2015

CPT: pharmacometrics & systems pharmacology

Disease Progression/Clinical Outcome Model for Castration-Resistant Prostate Cancer in Patients Treated With Eribulin.

01-07-2015

The British journal of nutrition

Dietary changes and dietary supplement use, and underlying motives for these habits reported by colorectal cancer survivors of the Patient Reported Outcomes Following Initial Treatment and Long-Term Evaluation of Survivorship (PROFILES) registry.

01-07-2015

EBioMedicine

Crowdsourcing the General Public for Large Scale Molecular Pathology Studies in Cancer.

01-07-2015

The lancet. Psychiatry

Patient-reported depression measures in cancer: a meta-review.

01-07-2015

Gene therapy

Antigen design enhances the immunogenicity of Semliki Forest virus-based therapeutic human papillomavirus vaccines.

01-07-2015

Molecular psychiatry

Brain organic cation transporter 2 controls response and vulnerability to stress and GSK3β signaling.

01-07-2015

Breast cancer research and treatment

The proportion of postmenopausal breast cancer cases in the Netherlands attributable to lifestyle-related risk factors.

01-07-2015

European journal of cancer (Oxford, England : 1990)

A phase IIb multicentre study comparing the efficacy of trabectedin to doxorubicin in patients with advanced or metastatic untreated soft tissue sarcoma: the TRUSTS trial.

01-07-2015

Trends in microbiology

Emerging intracellular receptors for hemorrhagic fever viruses.

01-07-2015

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

Variation in fatigue among 6011 (long-term) cancer survivors and a normative population: a study from the population-based PROFILES registry.

01-07-2015

Molecular biology of the cell

The rod domain is not essential for the function of plectin in maintaining tissue integrity.

01-07-2015

Nature chemical biology

Chemical profiling of the genome with anti-cancer drugs defines target specificities.

01-07-2015

CPT: pharmacometrics & systems pharmacology

Integrated Simulation Framework for Toxicity, Dose Intensity, Disease Progression, and Cost Effectiveness for Castration-Resistant Prostate Cancer Treatment With Eribulin.

01-07-2015

Cell research

A price to pay for tumor regression.

01-07-2015

mBio

Haploid Genetic Screen Reveals a Profound and Direct Dependence on Cholesterol for Hantavirus Membrane Fusion.

30-06-2015

BMC cancer

PIpelle Prospective ENDOmetrial carcinoma (PIPENDO) study, pre-operative recognition of high risk endometrial carcinoma: a multicentre prospective cohort study.

30-06-2015

British journal of cancer

Final results from the large sunitinib global expanded-access trial in metastatic renal cell carcinoma.

30-06-2015

Frontiers in oncology

Spatial Separation of Plk1 Phosphorylation and Activity.

27-06-2015

Science (New York, N.Y.)

GENE REGULATION. A HUSH for transgene expression.

26-06-2015

Immunotherapy

Targeting the T-cell co-stimulatory CD27/CD70 pathway in cancer immunotherapy: rationale and potential.

23-06-2015

Cell

Wnt Down, Tumors Wind Up?

18-06-2015

Nature

IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis.

18-06-2015

American journal of nuclear medicine and molecular imaging

The next evolution in radioguided surgery: breast cancer related sentinel node localization using a freehandSPECT-mobile gamma camera combination.

13-06-2015

Science (New York, N.Y.)

CELL DIVISION CYCLE. Competition between MPS1 and microtubules at kinetochores regulates spindle checkpoint signaling.

12-06-2015

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Effect of Low-Intensity Physical Activity and Moderate- to High-Intensity Physical Exercise During Adjuvant Chemotherapy on Physical Fitness, Fatigue, and Chemotherapy Completion Rates: Results of the PACES Randomized Clinical Trial.

10-06-2015

Journal of pharmaceutical and biomedical analysis

Development of an LC-MS/MS assay for the quantitative determination of the intracellular 5-fluorouracil nucleotides responsible for the anticancer effect of 5-fluorouracil.

10-06-2015

Cell host & microbe

Salmonella Manipulation of Host Signaling Pathways Provokes Cellular Transformation Associated with Gallbladder Carcinoma.

10-06-2015

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Challenges in the Use of DNA Repair Deficiency As a Biomarker in Breast Cancer.

10-06-2015