Publications

Ecancermedicalscience

Cancer immunotherapy: from the lab to clinical applications-Potential impact on cancer centres' organisation.

21-12-2016

Ecancermedicalscience

Close cooperation with Health Technology Assessment expertise is crucial for implementation and ultimately reimbursement of innovations in oncology.

21-12-2016

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Phase II Study of WEE1 Inhibitor AZD1775 Plus Carboplatin in Patients With TP53-Mutated Ovarian Cancer Refractory or Resistant to First-Line Therapy Within 3 Months.

20-12-2016

International journal of molecular sciences

Dermal Delivery of Constructs Encoding Cre Recombinase to Induce Skin Tumors in Pten^LoxP/LoxP;Braf^CA/+ Mice.

20-12-2016

Biomarker insights

Prognostic Value of MammaPrint^® in Invasive Lobular Breast Cancer.

17-12-2016

Genome biology

A novel independence test for somatic alterations in cancer shows that biology drives mutual exclusivity but chance explains most co-occurrence.

16-12-2016

Clinical cancer research : an official journal of the American Association for Cancer Research

Individualized Pazopanib Dosing-Response.

15-12-2016

British journal of cancer

Loss of KCNQ1 expression in stage II and stage III colon cancer is a strong prognostic factor for disease recurrence.

06-12-2016

eLife

Direct screening for chromatin status on DNA barcodes in yeast delineates the regulome of H3K79 methylation by Dot1.

06-12-2016

Oncotarget

Association of breast cancer risk with genetic variants showing differential allelic expression: Identification of a novel breast cancer susceptibility locus at 4q21.

06-12-2016

Ecancermedicalscience

Innovations that reach the patient: early health technology assessment and improving the chances of coverage and implementation.

03-12-2016

Ecancermedicalscience

Next-generation sequencing in NSCLC and melanoma patients: a cost and budget impact analysis.

03-12-2016

Hematology. American Society of Hematology. Education Program

Long-term risk of second malignancy and cardiovascular disease after Hodgkin lymphoma treatment.

02-12-2016

Clinical cancer research : an official journal of the American Association for Cancer Research

Individualized Pazopanib Dosing: A Prospective Feasibility Study in Cancer Patients.

01-12-2016

Journal of the National Cancer Institute

Long-term Outcome of an Organ Preservation Program After Neoadjuvant Treatment for Rectal Cancer.

01-12-2016

Therapeutic drug monitoring

Quantification of 11 Therapeutic Kinase Inhibitors in Human Plasma for Therapeutic Drug Monitoring Using Liquid Chromatography Coupled With Tandem Mass Spectrometry.

01-12-2016

European journal of radiology

Routine use of standard breast MRI compared to axillary ultrasound for differentiating between no, limited and advanced axillary nodal disease in newly diagnosed breast cancer patients.

01-12-2016

Human mutation

Am I My Family's Keeper? Disclosure Dilemmas in Next-Generation Sequencing.

01-12-2016

Journal of radiological protection : official journal of the Society for Radiological Protection

Confounding of the association between radiation exposure from CT scans and risk of leukemia and brain tumors by cancer susceptibility syndromes.

01-12-2016

European journal of cancer (Oxford, England : 1990)

Pathological downstaging and survival after induction chemotherapy and radical cystectomy for clinically node-positive bladder cancer-Results of a nationwide population-based study.

01-12-2016

Biomedical optics express

Using DRS during breast conserving surgery: identifying robust optical parameters and influence of inter-patient variation.

01-12-2016

Journal of medical genetics

PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS.

01-12-2016

The Lancet. Oncology

Biomarkers for outcome upon MAPK inhibition in melanoma.

01-12-2016

Journal of structural biology

A conserved two-step binding for the UAF1 regulator to the USP12 deubiquitinating enzyme.

01-12-2016

Breast (Edinburgh, Scotland)

Low risk of recurrence in elderly patients treated with breast conserving therapy in a single institute.

01-12-2016

Journal of mammary gland biology and neoplasia

p120-Catenin Is Critical for the Development of Invasive Lobular Carcinoma in Mice.

01-12-2016

European journal of cancer (Oxford, England : 1990)

Reference data of the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-CIPN20 Questionnaire in the general Dutch population.

01-12-2016

Journal of immunology (Baltimore, Md. : 1950)

GATA1-Deficient Dendritic Cells Display Impaired CCL21-Dependent Migration toward Lymph Nodes Due to Reduced Levels of Polysialic Acid.

01-12-2016

European journal of nuclear medicine and molecular imaging

Crossing technological frontiers in radioguided intervention.

01-12-2016

Virchows Archiv : an international journal of pathology

A critical evaluation of lymph node ratio in head and neck cancer.

01-12-2016

Nature cell biology

Lgr6 labels a rare population of mammary gland progenitor cells that are able to originate luminal mammary tumours.

01-12-2016

Clinical oncology (Royal College of Radiologists (Great Britain))

Functional Imaging in Radiotherapy in the Netherlands: Availability and Impact on Clinical Practice.

01-12-2016

Proteins

Structural basis of reversine selectivity in inhibiting Mps1 more potently than aurora B kinase.

01-12-2016

BMC cancer

Design of a randomized controlled trial of Internet-based cognitive behavioral therapy for treatment-induced menopausal symptoms in breast cancer survivors.

25-11-2016

BMC medical informatics and decision making

Operations research for resource planning and -use in radiotherapy: a literature review.

25-11-2016

Scientific reports

Logic models to predict continuous outputs based on binary inputs with an application to personalized cancer therapy.

23-11-2016

ESMO open

ESMO / ASCO Recommendations for a Global Curriculum in Medical Oncology Edition 2016.

16-11-2016

eLife

Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening.

15-11-2016

Clinical cancer research : an official journal of the American Association for Cancer Research

Focusing on Core Patient-Reported Outcomes in Cancer Clinical Trials-Letter.

15-11-2016

Cardio-oncology (London, England)

Cardiovascular co-morbidity in cancer patients: the role of psychological distress.

15-11-2016

Scientific reports

rs2735383, located at a microRNA binding site in the 3'UTR of NBS1, is not associated with breast cancer risk.

15-11-2016

Clinical cancer research : an official journal of the American Association for Cancer Research

Baseline Biomarkers for Outcome of Melanoma Patients Treated with Pembrolizumab.

15-11-2016

Breast cancer research : BCR

Inheritance of deleterious mutations at both BRCA1 and BRCA2 in an international sample of 32,295 women.

11-11-2016

Cell metabolism

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells.

08-11-2016

Oncotarget

Genomic profiling of stage II and III colon cancers reveals APC mutations to be associated with survival in stage III colon cancer patients.

08-11-2016

BMC cancer

A case series of intestinal adenomatous polyposis of unidentified etiology; a late effect of irradiation?

08-11-2016

Cold Spring Harbor symposia on quantitative biology

Genetic Dissection of Cancer Development, Therapy Response, and Resistance in Mouse Models of Breast Cancer.

07-11-2016

Cancer treatment reviews

Improving safety of fluoropyrimidine chemotherapy by individualizing treatment based on dihydropyrimidine dehydrogenase activity - Ready for clinical practice?

01-11-2016

Clinical pharmacokinetics

A Semi-Physiological Population Model to Quantify the Effect of Hematocrit on Everolimus Pharmacokinetics and Pharmacodynamics in Cancer Patients.

01-11-2016

European journal of cancer (Oxford, England : 1990)

Health-related quality of life in the randomised KEYNOTE-002 study of pembrolizumab versus chemotherapy in patients with ipilimumab-refractory melanoma.

01-11-2016