Publications

Cell reports

BRAF(V600E) Kinase Domain Duplication Identified in Therapy-Refractory Melanoma Patient-Derived Xenografts.

28-06-2016

Proceedings of the National Academy of Sciences of the United States of America

Defining chromosomal translocation risks in cancer.

28-06-2016

Cancer informatics

The Melanoma MAICare Framework: A Microsimulation Model for the Assessment of Individualized Cancer Care.

28-06-2016

Nederlands tijdschrift voor geneeskunde

[Radiotherapy in Europe].

24-06-2016

Acta oncologica (Stockholm, Sweden)

Neurocognitive function of lymphoma patients after treatment with chemotherapy.

23-06-2016

Oncotarget

Intrinsic resistance to PIM kinase inhibition in AML through p38α-mediated feedback activation of mTOR signaling.

21-06-2016

Breast cancer research : BCR

Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus.

21-06-2016

Trials

A phase I followed by a randomized phase II trial of two cycles carboplatin-olaparib followed by olaparib monotherapy versus capecitabine in BRCA1- or BRCA2-mutated HER2-negative advanced breast cancer as first line treatment (REVIVAL): study protocol for a randomized controlled trial.

21-06-2016

Scientific reports

OncoScape: Exploring the cancer aberration landscape by genomic data fusion.

20-06-2016

JAMA

Ovarian stimulation for in vitro fertilization and long-term risk of breast cancer

19-06-2016

Key Publication

mSphere

A Single Residue in Ebola Virus Receptor NPC1 Influences Cellular Host Range in Reptiles.

16-06-2016

Clinical cancer research : an official journal of the American Association for Cancer Research

TAS-102 for Treatment of Advanced Colorectal Cancers That Are No Longer Responding to Other Therapies.

15-06-2016

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Liquid chromatography-tandem mass spectrometric assay for ponatinib and N-desmethyl ponatinib in mouse plasma.

15-06-2016

Genes & development

Modeling invasive lobular breast carcinoma by CRISPR/Cas9-mediated somatic genome editing of the mammary gland.

15-06-2016

Clinical cancer research : an official journal of the American Association for Cancer Research

Baseline Peripheral Blood Biomarkers Associated with Clinical Outcome of Advanced Melanoma Patients Treated with Ipilimumab.

15-06-2016

BMC cancer

Variation in use of targeted therapies for metastatic renal cell carcinoma: Results from a Dutch population-based registry.

11-06-2016

Science (New York, N.Y.)

Targeting of cancer neoantigens with donor-derived T cell receptor repertoires.

10-06-2016

Nature communications

Cholesterol and ORP1L-mediated ER contact sites control autophagosome transport and fusion with the endocytic pathway.

10-06-2016

Health and quality of life outcomes

Thresholds for clinical importance for four key domains of the EORTC QLQ-C30: physical functioning, emotional functioning, fatigue and pain.

07-06-2016

Oncotarget

Neoadjuvant tamoxifen synchronizes ERα binding and gene expression profiles related to outcome and proliferation.

07-06-2016

Journal of pharmaceutical and biomedical analysis

Simultaneous quantification of dabrafenib and trametinib in human plasma using high-performance liquid chromatography-tandem mass spectrometry.

05-06-2016

Nature

Landscape of somatic mutations in 560 breast cancer whole-genome sequences.

02-06-2016

Nucleic acids research

PrimPol prevents APOBEC/AID family mediated DNA mutagenesis.

02-06-2016

European journal of immunology

Antigen-specific TIL therapy for melanoma: A flexible platform for personalized cancer immunotherapy.

01-06-2016

Acta oncologica (Stockholm, Sweden)

Time trends in axilla management among early breast cancer patients: Persisting major variation in clinical practice across European centers.

01-06-2016

Gut

Development and validation of the WASP classification system for optical diagnosis of adenomas, hyperplastic polyps and sessile serrated adenomas/polyps.

01-06-2016

AJR. American journal of roentgenology

Evaluation of a Hanging-Breast PET System for Primary Tumor Visualization in Patients With Stage I-III Breast Cancer: Comparison With Standard PET/CT.

01-06-2016

Nature methods

siFLIM: single-image frequency-domain FLIM provides fast and photon-efficient lifetime data.

01-06-2016

Frontiers in cellular neuroscience

ATP Released by Injured Neurons Activates Schwann Cells.

01-06-2016

Neuro-oncology

EpCAM-based flow cytometry in cerebrospinal fluid greatly improves diagnostic accuracy of leptomeningeal metastases from epithelial tumors.

01-06-2016

The British journal of radiology

Hybrid surgical guidance based on the integration of radionuclear and optical technologies.

01-06-2016

Annals of oncology : official journal of the European Society for Medical Oncology

Targeted treatment and immunotherapy in leptomeningeal metastases from melanoma.

01-06-2016

Cancer chemotherapy and pharmacology

A phase 0 clinical trial of novel candidate extended-release formulations of capecitabine.

01-06-2016

Current opinion in structural biology

Recombinant cloning strategies for protein expression.

01-06-2016

Cancer immunology, immunotherapy : CII

Concomitant targeting of programmed death-1 (PD-1) and CD137 improves the efficacy of radiotherapy in a mouse model of human BRAFV600-mutant melanoma.

01-06-2016

Investigational new drugs

Metabolite profiling of the multiple tyrosine kinase inhibitor lenvatinib: a cross-species comparison.

01-06-2016

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

Feasibility and impact of a dedicated multidisciplinary rehabilitation program on health-related quality of life in advanced head and neck cancer patients.

01-06-2016

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

Prospectively measured lifestyle factors and BMI explain differences in health-related quality of life between colorectal cancer patients with and without comorbid diabetes.

01-06-2016

Journal of genetic counseling

Communication Between Breast Cancer Patients Who Received Inconclusive Genetic Test Results and Their Daughters and Sisters Years After Testing.

01-06-2016

Clinical & experimental metastasis

Adhesion molecules in peritoneal dissemination: function, prognostic relevance and therapeutic options.

01-06-2016

Urologic oncology

Baseline tumor volume in assessing prognosis of patients with intermediate-risk synchronous metastatic renal cell carcinoma.

01-06-2016

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

MRI-guided prostate adaptive radiotherapy - A systematic review.

01-06-2016

Psycho-oncology

Patients are dissatisfied with information provision: perceived information provision and quality of life in prostate cancer patients.

01-06-2016

International journal of radiation oncology, biology, physics

Intrafraction Motion in Stereotactic Body Radiation Therapy for Non-Small Cell Lung Cancer: Intensity Modulated Radiation Therapy Versus Volumetric Modulated Arc Therapy.

01-06-2016

Journal of pharmacokinetics and pharmacodynamics

The performance of model-based versus rule-based phase I clinical trials in oncology : A quantitative comparison of the performance of model-based versus rule-based phase I trials with molecularly targeted anticancer drugs over the last 2 years.

01-06-2016

Cardiovascular research

Intracellular tortuosity underlies slow cAMP diffusion in adult ventricular myocytes.

01-06-2016

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research

Decisions on Further Research for Predictive Biomarkers of High-Dose Alkylating Chemotherapy in Triple-Negative Breast Cancer: A Value of Information Analysis.

01-06-2016

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

Treatment outcome of supraglottoplasty vs. wait-and-see policy in patients with laryngomalacia.

01-06-2016

Frontiers in bioscience (Landmark edition)

Invadosomes - shaping actin networks to follow mechanical cues.

01-06-2016

International journal of radiation oncology, biology, physics

Late Side Effects After Image Guided Intensity Modulated Radiation Therapy Compared to 3D-Conformal Radiation Therapy for Prostate Cancer: Results From 2 Prospective Cohorts.

01-06-2016

BRAF(V600E) Kinase Domain Duplication Identified in Therapy-Refractory Melanoma Patient-Derived Xenografts.

Defining chromosomal translocation risks in cancer.

The Melanoma MAICare Framework: A Microsimulation Model for the Assessment of Individualized Cancer Care.

[Radiotherapy in Europe].

Neurocognitive function of lymphoma patients after treatment with chemotherapy.

Intrinsic resistance to PIM kinase inhibition in AML through p38α-mediated feedback activation of mTOR signaling.

Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus.

A phase I followed by a randomized phase II trial of two cycles carboplatin-olaparib followed by olaparib monotherapy versus capecitabine in BRCA1- or BRCA2-mutated HER2-negative advanced breast cancer as first line treatment (REVIVAL): study protocol for a randomized controlled trial.

OncoScape: Exploring the cancer aberration landscape by genomic data fusion.

Ovarian stimulation for in vitro fertilization and long-term risk of breast cancer

A Single Residue in Ebola Virus Receptor NPC1 Influences Cellular Host Range in Reptiles.

TAS-102 for Treatment of Advanced Colorectal Cancers That Are No Longer Responding to Other Therapies.

Liquid chromatography-tandem mass spectrometric assay for ponatinib and N-desmethyl ponatinib in mouse plasma.

Modeling invasive lobular breast carcinoma by CRISPR/Cas9-mediated somatic genome editing of the mammary gland.

Baseline Peripheral Blood Biomarkers Associated with Clinical Outcome of Advanced Melanoma Patients Treated with Ipilimumab.

Variation in use of targeted therapies for metastatic renal cell carcinoma: Results from a Dutch population-based registry.

Targeting of cancer neoantigens with donor-derived T cell receptor repertoires.

Cholesterol and ORP1L-mediated ER contact sites control autophagosome transport and fusion with the endocytic pathway.

Thresholds for clinical importance for four key domains of the EORTC QLQ-C30: physical functioning, emotional functioning, fatigue and pain.

Neoadjuvant tamoxifen synchronizes ERα binding and gene expression profiles related to outcome and proliferation.

Simultaneous quantification of dabrafenib and trametinib in human plasma using high-performance liquid chromatography-tandem mass spectrometry.

Landscape of somatic mutations in 560 breast cancer whole-genome sequences.

PrimPol prevents APOBEC/AID family mediated DNA mutagenesis.

Antigen-specific TIL therapy for melanoma: A flexible platform for personalized cancer immunotherapy.

Time trends in axilla management among early breast cancer patients: Persisting major variation in clinical practice across European centers.

Development and validation of the WASP classification system for optical diagnosis of adenomas, hyperplastic polyps and sessile serrated adenomas/polyps.

Evaluation of a Hanging-Breast PET System for Primary Tumor Visualization in Patients With Stage I-III Breast Cancer: Comparison With Standard PET/CT.

siFLIM: single-image frequency-domain FLIM provides fast and photon-efficient lifetime data.

ATP Released by Injured Neurons Activates Schwann Cells.

EpCAM-based flow cytometry in cerebrospinal fluid greatly improves diagnostic accuracy of leptomeningeal metastases from epithelial tumors.

Hybrid surgical guidance based on the integration of radionuclear and optical technologies.

Targeted treatment and immunotherapy in leptomeningeal metastases from melanoma.

A phase 0 clinical trial of novel candidate extended-release formulations of capecitabine.

Recombinant cloning strategies for protein expression.

Concomitant targeting of programmed death-1 (PD-1) and CD137 improves the efficacy of radiotherapy in a mouse model of human BRAFV600-mutant melanoma.

Metabolite profiling of the multiple tyrosine kinase inhibitor lenvatinib: a cross-species comparison.

Feasibility and impact of a dedicated multidisciplinary rehabilitation program on health-related quality of life in advanced head and neck cancer patients.

Prospectively measured lifestyle factors and BMI explain differences in health-related quality of life between colorectal cancer patients with and without comorbid diabetes.

Communication Between Breast Cancer Patients Who Received Inconclusive Genetic Test Results and Their Daughters and Sisters Years After Testing.

Adhesion molecules in peritoneal dissemination: function, prognostic relevance and therapeutic options.

Baseline tumor volume in assessing prognosis of patients with intermediate-risk synchronous metastatic renal cell carcinoma.

MRI-guided prostate adaptive radiotherapy - A systematic review.

Patients are dissatisfied with information provision: perceived information provision and quality of life in prostate cancer patients.

Intrafraction Motion in Stereotactic Body Radiation Therapy for Non-Small Cell Lung Cancer: Intensity Modulated Radiation Therapy Versus Volumetric Modulated Arc Therapy.

The performance of model-based versus rule-based phase I clinical trials in oncology : A quantitative comparison of the performance of model-based versus rule-based phase I trials with molecularly targeted anticancer drugs over the last 2 years.

Intracellular tortuosity underlies slow cAMP diffusion in adult ventricular myocytes.

Decisions on Further Research for Predictive Biomarkers of High-Dose Alkylating Chemotherapy in Triple-Negative Breast Cancer: A Value of Information Analysis.

Treatment outcome of supraglottoplasty vs. wait-and-see policy in patients with laryngomalacia.

Invadosomes - shaping actin networks to follow mechanical cues.

Late Side Effects After Image Guided Intensity Modulated Radiation Therapy Compared to 3D-Conformal Radiation Therapy for Prostate Cancer: Results From 2 Prospective Cohorts.

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