Publications

Chemistry & biology

The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types.

23-12-2011

The Journal of experimental medicine

A genome-wide RNAi screen in mouse embryonic stem cells identifies Mp1 as a key mediator of differentiation.

19-12-2011

Bioinformatics (Oxford, England)

Automatic rebuilding and optimization of crystallographic structures in the Protein Data Bank.

15-12-2011

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

High-performance liquid chromatography analysis of a novel small-molecule, anti-cancer drug, Palomid 529, in human and mouse plasma and in mouse tissue homogenates.

15-12-2011

Cancer cell

BRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance.

13-12-2011

Trials

The impact of a cancer Survivorship Care Plan on gynecological cancer patient and health care provider reported outcomes (ROGY Care): study protocol for a pragmatic cluster randomized controlled trial.

05-12-2011

Molecular pharmaceutics

Hybrid peptide dendrimers for imaging of chemokine receptor 4 (CXCR4) expression.

05-12-2011

Lancet (London, England)

Tilting the AXIS towards therapeutic limits in renal cancer.

03-12-2011

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation

Suffering in long-term cancer survivors: an evaluation of the PRISM-R2 in a population-based cohort.

01-12-2011

Melanoma research

Expression of the embryological morphogen Nodal in stage III/IV melanoma.

01-12-2011

Human reproduction (Oxford, England)

Risk of borderline and invasive ovarian tumours after ovarian stimulation for in vitro fertilization in a large Dutch cohort.

01-12-2011

Journal of cancer research and clinical oncology

Postoperative serum proteomic profiles may predict recurrence-free survival in high-risk primary breast cancer.

01-12-2011

Journal of clinical epidemiology

Validation study suggested no differential misclassification of self-reported mammography history in BRCA1/2 mutation carriers.

01-12-2011

Bioanalysis

Bioanalytical aspects of clinical mass balance studies in oncology.

01-12-2011

Genome research

High-throughput semiquantitative analysis of insertional mutations in heterogeneous tumors.

01-12-2011

Cancer treatment reviews

Circulating tumor cells as pharmacodynamic biomarker in early clinical oncological trials.

01-12-2011

Biochemical Society transactions

Nesprin-3: a versatile connector between the nucleus and the cytoskeleton.

01-12-2011

Pigment cell & melanoma research

Oncogene-induced senescence and melanoma: where do we stand?

01-12-2011

International journal of pharmaceutics

Pharmaceutical development and preliminary clinical testing of an oral solid dispersion formulation of docetaxel (ModraDoc001).

28-11-2011

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Compromised health-related quality of life in patients with low-grade glioma.

20-11-2011

Nederlands tijdschrift voor geneeskunde

[Measuring quality of life in every oncological patient].

17-11-2011

Nederlands tijdschrift voor geneeskunde

[Issues around melanoma].

17-11-2011

International journal of radiation oncology, biology, physics

Fifteen-year radiotherapy outcomes of the randomized PORTEC-1 trial for endometrial carcinoma.

15-11-2011

The Biochemical journal

Phosphoinositide phosphatase SHIP-1 regulates apoptosis induced by edelfosine, Fas ligation and DNA damage in mouse lymphoma cells.

15-11-2011

Hum Mutat: Human mutation

ENIGMA--evidence-based network for the interpretation of germline mutant alleles: an international initiative to evaluate risk and clinical significance associated with sequence variation in BRCA1 and BRCA2 genes

03-11-2011

BMC cancer

A cost-effectiveness analysis of a preventive exercise program for patients with advanced head and neck cancer treated with concomitant chemo-radiotherapy.

03-11-2011

Breast cancer research and treatment

Association of the germline TP53 R72P and MDM2 SNP309 variants with breast cancer survival in specific breast tumor subgroups.

01-11-2011

Lung cancer (Amsterdam, Netherlands)

Tubulin, BRCA1, ERCC1, Abraxas, RAP80 mRNA expression, p53/p21 immunohistochemistry and clinical outcome in patients with advanced non small-cell lung cancer receiving first-line platinum-gemcitabine chemotherapy.

01-11-2011

Annals of oncology : official journal of the European Society for Medical Oncology

Phase I evaluation of telatinib, a VEGF receptor tyrosine kinase inhibitor, in combination with bevacizumab in subjects with advanced solid tumors.

01-11-2011

International journal of radiation oncology, biology, physics

Image-guided radiotherapy for breast cancer patients: surgical clips as surrogate for breast excision cavity.

01-11-2011

International journal of radiation oncology, biology, physics

Impact of preoperative radiotherapy on general and disease-specific health status of rectal cancer survivors: a population-based study.

01-11-2011

Breast cancer research and treatment

A non-BRCA1/2 hereditary breast cancer sub-group defined by aCGH profiling of genetically related patients.

01-11-2011

Breast cancer research : BCR

Quantitative copy number analysis by Multiplex Ligation-dependent Probe Amplification (MLPA) of BRCA1-associated breast cancer regions identifies BRCAness.

27-10-2011

Nature communications

Selective inhibition of microRNA accessibility by RBM38 is required for p53 activity.

25-10-2011

PloS one

3'UTR-mediated gene silencing of the Mixed Lineage Leukemia (MLL) gene.

15-10-2011

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

A sensitive combined assay for the quantification of paclitaxel, docetaxel and ritonavir in human plasma using liquid chromatography coupled with tandem mass spectrometry.

15-10-2011

The EMBO journal

Oestrogen receptor-co-factor-chromatin specificity in the transcriptional regulation of breast cancer.

14-10-2011

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Management of hot flashes in patients who have breast cancer with venlafaxine and clonidine: a randomized, double-blind, placebo-controlled trial.

10-10-2011

DNA repair

PCNA ubiquitination-independent activation of polymerase η during somatic hypermutation and DNA damage tolerance.

10-10-2011

PloS one

The histone demethylase Jarid1b (Kdm5b) is a novel component of the Rb pathway and associates with E2f-target genes in MEFs during senescence.

08-10-2011

Molecular cell

Mechanism of USP7/HAUSP activation by its C-terminal ubiquitin-like domain and allosteric regulation by GMP-synthetase.

07-10-2011

PLoS genetics

A barcode screen for epigenetic regulators reveals a role for the NuB4/HAT-B histone acetyltransferase complex in histone turnover.

01-10-2011

Current opinion in cell biology

Mechanisms of integrin activation and trafficking.

01-10-2011

European urology

Intraoperative laparoscopic fluorescence guidance to the sentinel lymph node in prostate cancer patients: clinical proof of concept of an integrated functional imaging approach using a multimodal tracer.

01-10-2011

Urology

A phase II study of presurgical sunitinib in patients with metastatic clear-cell renal carcinoma and the primary tumor in situ.

01-10-2011

Investigational new drugs

Paclitaxel in self-micro emulsifying formulations: oral bioavailability study in mice.

01-10-2011

Journal of analytical toxicology

Determination of sunitinib and its active metabolite N-desethylsunitinib in sweat of a patient.

01-10-2011

Cancer immunology, immunotherapy : CII

Combination of targeted therapy and immunotherapy in melanoma.

01-10-2011

Clinical endocrinology

Health-related quality of life among thyroid cancer survivors: a systematic review.

01-10-2011

International journal of pharmaceutics

Optimizing the therapeutic index of liposomal glucocorticoids in experimental arthritis.

20-09-2011