Publications

Lung cancer (Amsterdam, Netherlands)

Crizotinib-induced fatal fulminant liver failure.

European urology

ERBB2 Mutations Characterize a Subgroup of Muscle-invasive Bladder Cancers with Excellent Response to Neoadjuvant Chemotherapy.

Haematologica

Treatment with the HIV protease inhibitor nelfinavir triggers the unfolded protein response and may overcome proteasome inhibitor resistance of multiple myeloma in combination with bortezomib: a phase I trial (SAKK 65/08).

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Fractures of thoracic vertebrae in patients with locally advanced non-small cell lung carcinoma treated with intensity modulated radiotherapy.

PloS one

Targeted Next Generation Sequencing as a Reliable Diagnostic Assay for the Detection of Somatic Mutations in Tumours Using Minimal DNA Amounts from Formalin Fixed Paraffin Embedded Material.

27-02-2016

The Journal of biological chemistry

Rapid Remodeling of Invadosomes by Gi-coupled Receptors: DISSECTING THE ROLE OF Rho GTPases.

26-02-2016

Oncogene

Paclitaxel targets FOXM1 to regulate KIF20A in mitotic catastrophe and breast cancer paclitaxel resistance.

25-02-2016

Nature

Tumour-specific proline vulnerability uncovered by differential ribosome codon reading.

25-02-2016

Molecular cell

Cohesin Releases DNA through Asymmetric ATPase-Driven Ring Opening.

18-02-2016

Molecular cell

Releasing Activity Disengages Cohesin's Smc3/Scc1 Interface in a Process Blocked by Acetylation.

18-02-2016

Molecular cell

PARP1 Links CHD2-Mediated Chromatin Expansion and H3.3 Deposition to DNA Repair by Non-homologous End-Joining.

18-02-2016

Breast cancer research : BCR

Genetic predisposition to ductal carcinoma in situ of the breast.

17-02-2016

Clinical cancer research : an official journal of the American Association for Cancer Research

First-in-Human Phase I Study of Lumretuzumab, a Glycoengineered Humanized Anti-HER3 Monoclonal Antibody, in Patients with Metastatic or Advanced HER3-Positive Solid Tumors.

Behavioural brain research

Neurobiological changes by cytotoxic agents in mice.

Clinical cancer research : an official journal of the American Association for Cancer Research

Exposure and Tumor Fn14 Expression as Determinants of Pharmacodynamics of the Anti-TWEAK Monoclonal Antibody RG7212 in Patients with Fn14-Positive Solid Tumors.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Liquid chromatography-tandem mass spectrometric assay for the tyrosine kinase inhibitor afatinib in mouse plasma using salting-out liquid-liquid extraction.

The EMBO journal

Touch, act and go: landing and operating on nucleosomes.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Impact of Age at Primary Breast Cancer on Contralateral Breast Cancer Risk in BRCA1/2 Mutation Carriers.

10-02-2016

BMC Bioinformatics

Analysing multiple types of molecular profiles simultaneously: connecting the needles in the haystack

09-02-2016

Key Publication

BMC cancer

Scenario drafting for early technology assessment of next generation sequencing in clinical oncology.

06-02-2016

BMC medical ethics

Exceptions to the rule of informed consent for research with an intervention.

06-02-2016

Circulation research

Genome-Wide Polyadenylation Maps Reveal Dynamic mRNA 3'-End Formation in the Failing Human Heart.

05-02-2016

Molecular cell

HELB Is a Feedback Inhibitor of DNA End Resection.

04-02-2016

Proceedings of the National Academy of Sciences of the United States of America

Enterovirus D68 receptor requirements unveiled by haploid genetics.

02-02-2016

British journal of cancer

Heterogeneity of luminal breast cancer characterised by immunohistochemical expression of basal markers.

02-02-2016

Genetics in medicine : official journal of the American College of Medical Genetics

Does rapid genetic counseling and testing in newly diagnosed breast cancer patients cause additional psychosocial distress? results from a randomized clinical trial.

Cancer treatment reviews

Risk of subsequent gastrointestinal cancer among childhood cancer survivors: A systematic review.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

Real-time in vivo assessment of radiofrequency ablation of human colorectal liver metastases using diffuse reflectance spectroscopy.

Journal of virology

A Haploid Genetic Screen Identifies Heparan Sulfate Proteoglycans Supporting Rift Valley Fever Virus Infection.

Investigational new drugs

Trastuzumab and bevacizumab combined with docetaxel, oxaliplatin and capecitabine as first-line treatment of advanced HER2-positive gastric cancer: a multicenter phase II study.

European journal of cancer (Oxford, England : 1990)

Renal function, body surface area, and age are associated with risk of early-onset fluoropyrimidine-associated toxicity in patients treated with capecitabine-based anticancer regimens in daily clinical care.

International journal of cancer

Ritonavir inhibits intratumoral docetaxel metabolism and enhances docetaxel antitumor activity in an immunocompetent mouse breast cancer model.

DNA repair

The conserved molecular machinery in DNA mismatch repair enzyme structures.

European journal of cancer (Oxford, England : 1990)

Perioperative treatment and radical cystectomy for bladder cancer--a population based trend analysis of 10,338 patients in the Netherlands.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

Cytoreduction and hyperthermic intraperitoneal chemotherapy: The learning curve reassessed.

PLoS genetics

3'UTR Shortening Potentiates MicroRNA-Based Repression of Pro-differentiation Genes in Proliferating Human Cells.

Cancer discovery

DNA-Guided Precision Medicine for Cancer: A Case of Irrational Exuberance?

World journal of urology

Neoadjuvant induction dose-dense MVAC for muscle invasive bladder cancer: efficacy and safety compared with classic MVAC and gemcitabine/cisplatin.

Inflammatory bowel diseases

CD151 Regulates T-Cell Migration in Health and Inflammatory Bowel Disease.

Oncoimmunology

Systemic inflammation: Cancer's long-distance reach to maximize metastasis.

Nature biotechnology

Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

Correlates of physical activity among colorectal cancer survivors: results from the longitudinal population-based profiles registry.

Journal of pharmaceutical and biomedical analysis

Liquid chromatography-tandem mass spectrometric assay for the simultaneous determination of the irreversible BTK inhibitor ibrutinib and its dihydrodiol-metabolite in plasma and its application in mouse pharmacokinetic studies.

25-01-2016

Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

23-01-2016

Journal for immunotherapy of cancer

Novel technologies and emerging biomarkers for personalized cancer immunotherapy.

21-01-2016

J Clin Oncol.

Radiation dose-response relationship for risk of coronary heart disease in survivors of Hodgkin lymphoma

Key Publication

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Radiation Dose-Response Relationship for Risk of Coronary Heart Disease in Survivors of Hodgkin Lymphoma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Upfront Genotyping of DPYD*2A to Individualize Fluoropyrimidine Therapy: A Safety and Cost Analysis.

Radiation oncology (London, England)

Lungtech, a phase II EORTC trial of SBRT for centrally located lung tumours - a clinical physics perspective.